The Effect of Persisting Hypovolemic Shock on Pancreatic Output of Insulin

Drucker, William R.; Gallie, Brenda L.; Lau, T. S.; Farago, G. A.; Levene, R. A.; Haist, R. E.

doi:10.1007/978-1-4684-3228-2_19

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…According to Bergstrom et al 45 , an increased glycogen content is one of the main determinants for performance in moderate and prolonged exercise. In addition, the dependence on carbohydrates in high-intensity and long-term physical exercises is well recognized 46 . To confirm this, previous studies by our group demonstrated that, when submitted to endurance exercise until exhaustion at individualized intensities of effort corresponding to the maximal aerobic capacity, Wistar rats (92 days old) showed a depletion of the glycogen content in the gluteus maximus immediately after swimming exercise, among other effects (p < 0.05) 47 .…”

Section: Discussionmentioning

confidence: 99%

Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort

Faria

Pejon

Gobatto

et al. 2021

Sci Rep

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The present study investigated the effects of acute melatonin administration on the biomarkers of energy substrates, GLUT4, and FAT/CD36 of skeletal muscle and its performance in rats subjected to exhaustive swimming exercise at an intensity corresponding to the maximal aerobic capacity (tlim). The incremental test was performed to individually determine the exercise intensity prescription and 48 h after, the animals received melatonin (10 mg·kg−1) or vehicles 30 min prior to tlim. Afterwards, the animals were euthanized 1 or 3 h after the exhaustion for blood and muscles storage. The experiment 1 found that melatonin increased the content of glycogen and GLUT4 in skeletal muscles of the animals that were euthanized 1 (p < 0.05; 22.33% and 41.87%) and 3 h (p < 0.05; 37.62% and 57.87%) after the last procedures. In experiment 2, melatonin enhanced the tlim (p = 0.01; 49.42%), the glycogen content (p < 0.05; 40.03%), GLUT4 and FAT/CD36 in exercised skeletal muscles (F = 26.83 and F = 25.28, p < 0.01). In summary, melatonin increased energy substrate availability prior to exercise, improved the exercise tolerance, and accelerated the recovery of muscle energy substrates after the tlim, possibly through GLUT4 and FAT/CD36.

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Section: Discussionmentioning

confidence: 99%

Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort

Faria

Pejon

Gobatto

et al. 2021

Sci Rep

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“…The effect of several types of trauma on the circulating levels of immunoreactive insulin has been studied in a number of species including man (e.g. Ross et al, 1966;Halmagyi et al, 1966;Allison, Hinton and Chamberlain, 1968;Bauer et al, 1969;Carey, Lowery and Cloutier, 1970;Cryer et al, 1972;Cerchio et al, 1971;Drucker et al, 1973, Vigas et al, 1973. The results have been variable.…”

Section: Effect Of Trauma On Insulin Secretionmentioning

confidence: 99%

The Effects of Trauma on Carbohydrate Metabolism

Stoner¹,

Heath²

1973

British Journal of Anaesthesia

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The rise of blood sugar as parameter for the degree of severity of hemorrhagic shock in the rabbit

Holzrichter¹,

Burk²,

Korn³

et al. 1983

Arch. Orth. Traum. Surg.

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Besides the known cardiovascular effects of hemorrhagic shock, the following regular metabolic consequences can be demonstrated in rabbits: The rise in blood sugar in hemorrhagic shock increases with the amount of blood withdrawn per unit time. The rise in blood sugar is independent of the state of consciousness or Nembutal anesthesia. The characteristic rise in blood sugar lasts longer than the partial exsanguination phase. The rise in blood sugar is attributed to an increased glycogenolysis due to a reflex triggering of catecholamine secretion via the baroreceptors in hemorrhagic shock. More attention to metabolic consequences of hemorrhagic shock may possibly give rise to consequences for diagnosis and therapy of shock.

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The Effect of Persisting Hypovolemic Shock on Pancreatic Output of Insulin

Cited by 3 publications

References 8 publications

Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort

Acute melatonin administration improves exercise tolerance and the metabolic recovery after exhaustive effort

The Effects of Trauma on Carbohydrate Metabolism

The rise of blood sugar as parameter for the degree of severity of hemorrhagic shock in the rabbit

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