The effect of perfluorooctadecanoic acid on a model phosphatidylcholine–peptide pulmonary lung surfactant mixture

Eftaiha, Ala’a F.; Tremblay, Marie‐Laurence; Rainey, Jan K.; Paige, Matthew F.

doi:10.1016/j.jfluchem.2015.05.005

Cited by 5 publications

(6 citation statements)

References 32 publications

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“…Moreover, the collapse pressure of the mixed monolayers (in both systems) is larger than the pure components regardless of the mole fraction. The high surface pressure values of the mixed monolayers are of particular interest for surface scientists working in the field of pulmonary surfactants, where additives − are used to inhibit the crystallization of DPPC (the main component of endogenous lung surfactant) at high compression pressure, without affecting its ability to reduce surface tension. The reasonable elasticity values of S (NA + -C 16 ) 2 ·2Br films (>100 mN/m), in comparison with the benchmark DPPC molecule (Figure S33, Supporting Information), suggest the potential use of the NA based surfactants in synthetic pulmonary surfactant preparations.…”

Section: Resultsmentioning

confidence: 99%

Interfacial Behavior of Modified Nicotinic Acid as Conventional/Gemini Surfactants

et al. 2022

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We report the synthesis and monolayer properties of conventional and gemini surfactants composed of nicotinic acid-based head groups with an emphasis on assessing how chemical structures affect the behavior of monolayers. A combination of Brewster angle microscopy and atomic force microscopy showed that pure hexadecyl nicotinate formed rippled strands in monolayers, and the gemini correspondents with either flexible or rigid organic linkers resulted in lobed-compact domains, which provides a simple method for patterning air-water and solid-air interfaces. The structural differences between conventional and gemini nicotinic acid-based surfactants could be explained by the interplay between line tension (that favors the formation of circular domains), balanced by dipole−dipole repulsion interaction between headgroups, which promotes extended domains. Miscibility and morphology studies of the modified nicotinic acid surfactants with palmitic acid demonstrated that the properties of mixed films can be controlled by the structure of the former. Excess Gibbs free energies of mixing indicated that the mixed films were less stable than the pure monolayers, and the positive deviations from ideality were the largest in the case of gemini surfactants.

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Section: Resultsmentioning

confidence: 99%

Interfacial Behavior of Modified Nicotinic Acid as Conventional/Gemini Surfactants

et al. 2022

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“…This was similar to our previous work on examining mixed films comprised of perfluorinated and hydrogenated surfactants. [42][43][44] Starting with PA, the BAM image ( Figure 5A) showed a film consisting of a series of fused, interconnected domains, with the occurrence of discrete circular domains with considerable differences in the contrast. These variations are likely caused by differences in film thickness and possibly azimuthal tilt angles.…”

Section: Resultsmentioning

confidence: 99%

Morphological and Interaction Characteristics of Surface‐Active Ionic Liquids and Palmitic Acid in Mixed Monolayers

et al. 2020

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A series of water soluble, surface‐active ionic liquids (SAILs), namely, 1‐alkyl‐3‐methyl imidazolium chlorides ([Cn‐mim]Cl) and their mixtures with palmitic acid (PA) are investigated in Langmuir monolayers and Langmuir–Blodgett films. It is inferred from the surface pressure‐area isotherms that C16‐mim‐IL mixes non‐ideally with PA and stabilizes the binary mixed films. In addition, the residence of mim‐IL at the water surface is enhanced as a function of the increasing alkyl side chain length. Generally, the compressional moduli values decrease upon increasing the content of the mim‐ILs over a wide range of compositions. Furthermore, film relaxation measurements indicate that the IL component is selectively excluded from the mixed films upon achieving a certain target pressure. Brewster angle microscope images demonstrate minimal changes on the PA domains in the presence of either C4‐ and C8‐mim‐ILs, whereas presence of the hexadecyl counterpart results in the formation of condensed sheets. Atomic force microscopy imaging of deposited films show the formation of propeller‐like aggregates when C8‐ or C16‐mim‐IL is present in the mixed films.

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“…Similar effects have been reported by Morigaki et al for photopolymerizable phospholipids. Measurements at the air–water interface revealed that photopolymerization results in a complex expansion-contraction behavior at the air–water interface involving simultaneous competing processes (lateral expansion due to polymerization, filling of voids in the film and film “buckling”) during UV illumination . More importantly, an anisotropic alignment of polymer material was detected at the interface which was caused by the trough barriers exerting mechanical stress on the film.…”

Section: Morphology Study Of Hydrocarbon–fluorocarbon Mixed Monolayersmentioning

confidence: 99%

“…The newly formed polymer structures were significantly larger than individual PCDA molecules. It was postulated that such structures were polydiacetylene bilayers vertically oriented to the substrate surface, 57 with structures forming through buckling of the rigid polydiacetylene polymers that were constrained onto the solid surface. Similar effects have been reported by Morigaki et al 56 for photopolymerizable phospholipids.…”

Section: ■ Morphology Study Of Hydrocarbon−fluorocarbon Mixed Monolayersmentioning

confidence: 99%

“…Measurements at the air−water interface revealed that photopolymerization results in a complex expansion-contraction behavior at the air−water interface involving simultaneous competing processes (lateral expansion due to polymerization, filling of voids in the film and film "buckling") during UV illumination. 57 More importantly, an anisotropic alignment of polymer material was detected at the interface which was caused by the trough barriers exerting mechanical stress on the film. Additional studies revealed that preparing films with a large content of C13F (H:F= 1:4) promoted the formation of fiberlike domains that exhibit the same tendency for alignment at the air−water interface.…”

Section: ■ Morphology Study Of Hydrocarbon−fluorocarbon Mixed Monolayersmentioning

confidence: 99%

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Pattern Formation in Phase-Separated Langmuir and Langmuir Monolayer Films

Yan

Paige

2021

Langmuir

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Mixed monolayer films comprising hydrogenated and fluorinated surfactants can undergo phase separation to produce interfaces with diverse structures at the micrometer and nanometer scales. This review discusses our progress over the past decade to probe the relationship that exists between the molecular structure of the surfactants that comprise the films and the overall patterns formed in the monolayers. We review two main classes of mixed perfluorocarbon–hydrocarbon surfactant systems, including fatty acids and a recently developed family of EDTA-based gemini surfactants. In addition to summarizing the state-of-the-art of this field, the key scientific questions and relationships that require further elucidation are discussed, along with directions for continuing research into this fascinating area of research.

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The effect of perfluorooctadecanoic acid on a model phosphatidylcholine–peptide pulmonary lung surfactant mixture

Cited by 5 publications

References 32 publications

Interfacial Behavior of Modified Nicotinic Acid as Conventional/Gemini Surfactants

Interfacial Behavior of Modified Nicotinic Acid as Conventional/Gemini Surfactants

Morphological and Interaction Characteristics of Surface‐Active Ionic Liquids and Palmitic Acid in Mixed Monolayers

Pattern Formation in Phase-Separated Langmuir and Langmuir Monolayer Films

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