The Effect of Peptic and Tryptic Digestion on the Antigenicity of Trichinella Spiralis1

The Effect on the Trichinella Skin Test of Simultaneous Infection With Bovine Tuberculosis in Trichinous Rabbits 1

“…The differences in reaction to trichinella antigen at 20 minutes, 24 hours and 48 hours are of interest in the light of experiments recently performed on dogs, using trichinella antigen digested with pepsin or trypsin, and presumably containing no reaginic protein (8) Further experiments have been carried out in orphanage and prison groups, in order to compare the tuberculin and trichinella skin reactions in non-tuberculous, non-psychiatric institutionalized persons. These clinical experiments, which are being reported separately (3), confirm the animal experiments reported here; no biologic cross reaction seems to exist between the 2 infectious agents.…”

The Immunophysiology of Trichinosis. Alterations in the Blood Volume and the Thiocyanate Space in Relation to the Development of Humoral Antibodies in the Rabbit 1

“…(7); it is possible that the antigenic components of immature, unencysted trichinella larvae may also be slightly different from the mature encysted forms. Previous studies have demonstrated that peptic and tryptic digestion destroys the protein fraction of the larvae, but does not destroy the antigenicity of some remaining component which presumably is a carbohydrate (8). The adult female attaches to the intestinal mucosa and secretes an antigen which probably is of little significance in the acute disease; the antibody, however, is concerned with the prevention of re-infection.…”

Trichinella Skin Tests in an Orphanage and Prison. Comparison With Serologic Tests for Trichinosis and With the Tuberculin Reaction 1

“…The length of time for which flocculating antibodies persist in human beings is not known, but in swine the test remains positive for 10 months (4). It is possible that different antigens are involved in the production of the skin test and the serum reactions (6).…”