The effect of pentobarbital anaesthesia upon the extracellular fluid volume in the dog, studied by continuous infusion and single injection methods

Zweens, J; Frankena, Henny; Zijlstra, Wg

doi:10.1007/bf00581576

Cited by 11 publications

(12 citation statements)

References 28 publications

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“…The expected change would however be small and may be masked by the sodium movement into this compartment. ZWEENS et al (1978), produced results which contrast with the present findings and those of RAMPTON and RAMSAY (1974). They measured a 10% fall in ECF volume 30 min after anaesthesia with pentobarbitone.…”

Section: Resultscontrasting

confidence: 99%

“…The high urinary flow rates consequent upon the infusion are highly untypical of the pentobarbitone anaesthetised dog (GLASBY and RAMSAY, 1974), and the endogenous fluid shifts and haemodynamic changes may be a response to these imposed measures. ZWEENS et al (1978) make the point that ferrocyanide and mannitol are similar with regard to particle size and argue for similar diffusion characteristics. However, the penetration of liver cells is not taken into account here and they do not indicate whether they have ruled out this possibility in earlier work.…”

Section: Resultsmentioning

confidence: 99%

“…This may to some extent account for the differences in observed changes. It is very apparent from the detailed evaluations of ZWEENS et al (1978) that the method of measuring ECF volume is a crucial consideration in the interpretation of the results. ZWEENS et al (1978) favour a continuous infusion of indicator on the grounds that they feel that the single injection technique does not ensure adequate equilibration and they suggest that their results cannot be compared with those of BONNEYCASTLE (1942) and RAMPTON and RAMSAY (1974) in technique.…”

Section: Resultsmentioning

confidence: 99%

“…It is very apparent from the detailed evaluations of ZWEENS et al (1978) that the method of measuring ECF volume is a crucial consideration in the interpretation of the results. ZWEENS et al (1978) favour a continuous infusion of indicator on the grounds that they feel that the single injection technique does not ensure adequate equilibration and they suggest that their results cannot be compared with those of BONNEYCASTLE (1942) and RAMPTON and RAMSAY (1974) in technique. NEWMAN et al (1944), DOMINGUEZ et al (1947), ELKINGTON (1947) and RAMPTON (1970) have studied the mannitol method in great detail and if one takes into account the additional finding of GLASBY (1985) that the marker penetrates the liver cells, there seems to be ample evidence to vindicate this method.…”

Section: Resultsmentioning

confidence: 99%

“…In addition they failed to measure plasma volume prior to the administration of anaesthetic and were consequently unable to comment on fluid shifts relating to this subcompartment of the ECF. ZWEENS et al (1978), using a continuous infusion of ferrocyanide as an indicator for ECF volume measured a fall of 10% from conscious values 30 min after the induction of anaesthesia with pentobarbitone. These results are in direct conflict with those of RAMPTON and RAMSAY (1974) and the experiments reported here attempt to shed some light on this apparent discrepancy.…”

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confidence: 99%

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Extracellular fluid volume and composition changes during sodium pentobarbitone anaesthesia in the dog.

Davies

Glasby²

1986

Jpn.J.Physiol

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Serial, measurements of extracellular fluid (ECF), and plasma volumes were evaluated in dogs before and during general anaesthesia with sodium pentobarbitone and under controlled conditions of arterial pH, Pot' Pco2' and blood pressure. Sodium pentobarbitone anaesthesia caused an early, significant rise in ECF volume with a fall in haematocrit, plasma protein, and plasma potassium concentrations. Plasma osmolality and sodium concentrations were unchanged. The lack of change in ECF sodium concentration suggests that the total ECF sodium content increased in parallel with the expansion of this compartment. Sodium bound to macromolecules inn the interstitial space or to bone is suggested as a possible source of sodium ions. It is unlikely that intracellular sodium stores contribute to a significant extent in these changes. During prolonged anaesthesia plasma volume progressively increased while total ECF volume returned towards control values.This work clarifies previous observations and suggests that major fluid movements occur during sodium pentobarbitone anaesthesia primarily associated with altered cell membrane properties and generalised haemodynamic changes.

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Section: Resultscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Extracellular fluid volume and composition changes during sodium pentobarbitone anaesthesia in the dog.

Davies

Glasby²

1986

Jpn.J.Physiol

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Influence of high-dose methotrexate on the distribution of body fluid volumes in the dog

Degraaf

Devries

Zijlstra

1986

Cancer Chemother. Pharmacol.

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We studied the influence of high-dose methotrexate (HDMTX) on body fluid volumes in the dog, using indicator dilution techniques. In six healthy mongrel dogs total body water volume (TBW), extracellular water volume (ECW), body mass, and plasma osmolality were measured before and after infusion of both saline and HDMTX. TBW and ECW were determined simultaneously, using a double-indicator (D2O/ferrocyanide), single injection technique. In vitro experiments confirmed the reliability of ferrocyanide as an indicator for ECW, also in the presence of methotrexate. Results showed an increase in ECW after HDMTX (P = 0.029, paired Student's t-test), while TBW remained constant. Infusion of the same volume of isotonic saline in the control experiments did not result in any demonstrable change in either TBW or ECW. Therefore, infusion of HDMTX appears to cause a water shift from the intracellular to the extracellular compartment. Such a change in body water volumes may have implications for estimates of body composition and for pharmacokinetic studies in cancer patients receiving HDMTX.

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The extrarenal effects of aldosterone on the distribution of extracellular fluid in conscious adrenalectomized-nephrectomized rats

1985

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In order to examine the extrarenal roles of aldosterone in cardiovascular homeostasis, the present study compared blood pressure, extracellular fluid volume (ECFV) and plasma volume (PV) in the three following groups: 10 nephrectomized (NX) rats, 10 nephrectomized-adrenalectomized (NX-AX) rats, and 10 NX-AX and aldosterone-treated (NX-AX-A) rats. Two-hundred and fifty micrograms of aldosterone, mixed with sesame oil, was given subcutaneously in the NX-AX-A rats. Mean arterial pressure (MAP) was recorded through previously implanted carotid catheters. ECFV and PV were measured using 35S-Na2SO4 and 131I-RISA, respectively, 24 h after the operation. These measurements were performed in an unanesthetized and unrestricted condition. MAP gradually increased in the NX group, while a gradual decrease was observed in the other groups. However, MAP was significantly higher in the NX-AX-A group than in the NX-AX group 6 h after the operation and thereafter. Changes in body weight were comparable in the three groups 24 h after the operation. ECFV and PV were both reduced in the NX-AX and the NX-AX-A groups as compared to the NX group (P less than 0.001 NX-AX vs NX, and P less than 0.05 and P less than 0.025 NX-AX-A vs NX, respectively). Although ECFV was comparable in the NX-AX and the NX-AX-A groups, PV was significantly greater in the NX-AX-A group than in the NX-AX group (P less than 0.05). There was a significant positive correlation between MAP and PV in the rats as a whole (r = 0.68, P less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

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The effect of pentobarbital anaesthesia upon the extracellular fluid volume in the dog, studied by continuous infusion and single injection methods

Cited by 11 publications

References 28 publications

Extracellular fluid volume and composition changes during sodium pentobarbitone anaesthesia in the dog.

Extracellular fluid volume and composition changes during sodium pentobarbitone anaesthesia in the dog.

Influence of high-dose methotrexate on the distribution of body fluid volumes in the dog

The extrarenal effects of aldosterone on the distribution of extracellular fluid in conscious adrenalectomized-nephrectomized rats

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