The effect of PEG groups on swelling properties of PEG-grafted-polystyrene resins in various solvents

Park, Byeong-Deog; Lee, Jun Young

doi:10.1016/s1381-5148(99)00075-9

Cited by 24 publications

(6 citation statements)

References 16 publications

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“…Within the system of the tested solvents, there were not much difference in the product yield. We expected to observe a direct relationship between the resin swelling and the synthetic efficiency of the P-PDI bolaamphiphile by controlling the distance between the reaction sites within the resin matrix . As shown in Table , although there was a tendency of increasing dimerization yield with an increase in resin swelling, swelling did not appear to be a critical factor in this instance.…”

Section: Resultsmentioning

confidence: 99%

Solid-Phase Synthesis of Peptide-Conjugated Perylene Diimide Bolaamphiphile and Its Application in Photodynamic Therapy

et al. 2018

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Here, we describe a rapid and efficient synthetic method of peptide-conjugated perylene diimide (P-PDI) using solid-phase peptide synthesis (SPPS). Due to severe insolubility of perylene dianhydride (PDA) as a starting material of perylene diimide (PDI), PDA was initially conjugated with amino acids to obtain soluble PDI derivatives. Target peptides were synthesized on a 2-chlorotrityl chloride resin using the SPPS method and then conjugated with the amino acid-appended PDI. Various conditions such as loading levels, reaction times and solvents were optimized for introducing the peptides to both sides of the amino acid-appended PDI. The final P-PDI was obtained with a maximum yield of 80% in 12 h. Its singlet oxygen-derived phototoxicity on cells was confirmed, which could be applicable to photodynamic therapy.

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Section: Resultsmentioning

confidence: 99%

Solid-Phase Synthesis of Peptide-Conjugated Perylene Diimide Bolaamphiphile and Its Application in Photodynamic Therapy

et al. 2018

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“…The surface microroughness of the LbL silk ionomers is in good agreement with the data demonstrated for other LbL silk ionomer films. , On the other hand, it is known that PEG segments swell well in phosphate buffer, , and thus swollen PEG loops can result in the significant increase of surface microroughness of the (SF-Glu/SF-Lys[PEG]) 5 LbL coatings and the appearance of about 50 nm grainy surface features in contrast to the purely anionic–cationic paired silk ionomers (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Interfacial Shear Strength and Adhesive Behavior of Silk Ionomer Surfaces

et al. 2017

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The interfacial shear strength between different layers in multilayered structures of layer-by-layer (LbL) microcapsules is a crucial mechanical property to ensure their robustness. In this work, we investigated the interfacial shear strength of modified silk fibroin ionomers utilized in LbL shells, an ionic-cationic pair with complementary ionic pairing, (SF)-poly-l-glutamic acid (Glu) and SF-poly-l-lysine (Lys), and a complementary pair with partially screened Coulombic interactions due to the presence of poly(ethylene glycol) (PEG) segments and SF-Glu/SF-Lys[PEG] pair. Shearing and adhesive behavior between these silk ionomer surfaces in the swollen state were probed at different spatial scales and pressure ranges by using functionalized atomic force microscopy (AFM) tips as well as functionalized colloidal probes. The results show that both approaches were consistent in analyzing the interfacial shear strength of LbL silk ionomers at different spatial scales from a nanoscale to a fraction of a micron. Surprisingly, the interfacial shear strength between SF-Glu and SF-Lys[PEG] pair with partially screened ionic pairing was greater than the interfacial shear strength of the SF-Glu and SF-Lys pair with a high density of complementary ionic groups. The difference in interfacial shear strength and adhesive strength is suggested to be predominantly facilitated by the interlayer hydrogen bonding of complementary amino acids and overlap of highly swollen PEG segments.

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“…The motion of analyte molecules is also strongly affected by the nature of the polymer matrix. For example, grafted polyethylene chains alter the physical and chemical aspects of the polystyrene resins, making it amphiphilic instead of hydrophobic …”

Section: Resultsmentioning

confidence: 99%

Applicability of Imaging Time-of Flight Secondary Ion MS to the Characterization of Solid-Phase Synthesized Combinatorial Libraries

Braun

Winograd

2003

Anal. Chem.

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We employ imaging time-of-flight secondary ion mass spectrometry to perform high-throughput analysis of solid-phase synthesized combinatorial libraries by acquiring mass spectra from arrays of polymer resin particles. To generalize this procedure to various types of resins and their associated chemical linkers, it is necessary to understand the dynamics associated with the analyte molecules during chemical pretreatment steps. Using stearic acid as a model compound, we examine the influence of three classes of linkers-acid or base labile linkers, a thermally labile linker, and a photochemically cleavable linker- all of which are used to anchor one end of the analyte to the polymer resin. With data obtained using secondary ion mass spectrometry, scanning electron microscopy, and X-ray photoelectron spectroscopy, we conclude that an effective treatment of the resin needs to include cleaving the linker and extracting the unbound analyte to the resin surface. We also demonstrate that the hydrophilicity of the polymeric constituents of a resin particle affects the experiments by changing the location of the analyte molecules during resin treatment. With this information, it is possible to utilize imaging TOF-SIMS to assay a range of material supports with assurance that high-quality spectra can be acquired.

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The effect of PEG groups on swelling properties of PEG-grafted-polystyrene resins in various solvents

Cited by 24 publications

References 16 publications

Solid-Phase Synthesis of Peptide-Conjugated Perylene Diimide Bolaamphiphile and Its Application in Photodynamic Therapy

Solid-Phase Synthesis of Peptide-Conjugated Perylene Diimide Bolaamphiphile and Its Application in Photodynamic Therapy

Interfacial Shear Strength and Adhesive Behavior of Silk Ionomer Surfaces

Applicability of Imaging Time-of Flight Secondary Ion MS to the Characterization of Solid-Phase Synthesized Combinatorial Libraries

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