The effect of Pb and Cd uptake on Zn and Cu levels in hard and soft tissues of rats†

Wesenberg, Gro Ramsten; Fosse, Gisle; Rasmussen, Per; Justesen, Nils-Petter Berg

doi:10.1080/00207238008737422

Cited by 5 publications

(10 citation statements)

References 38 publications

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“…15 The results of the present study, where no increased Zn levels were found in the soft tissues of the nine and 15 week old rats (see Table II), are thus in agreement with the results of the two previous experiments referred to above. Several authors have, however, described an increase of Zn in soft tissues, especially kidney cortex and liver, following the administration of Cd orally or by injection.…”

Section: Discussionsupporting

confidence: 95%

“…All tissues were treated as described previously. 15 ' 17 ' 18 The Pb and Cu ions of the hard tissues from all groups were extracted by chelation with APDCsaturated xylene, while in the hard tissues Zn was measured directly from the HC1 digested samples prior to extraction. In the soft tissues and hair all three elements were measured directly from the HNO 3 -digested samples.…”

Section: Atomic Absorption Analysesmentioning

confidence: 99%

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Effect of acute exposure to cadmium on zinc, copper and lead contents of hard and soft tissues of rats

Wesenberg

1983

International Journal of Environmental Studies

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Eleven groups of Wistar rats were given 5 ppm cadmium acetate in the drinking water at different and interrupted periods of their life (in utero, during sucking etc.), simulating acute exposure. The Zn, Cu and Pb levels of indicators (teeth and hair) and target organs (soft tissues and bone) were recorded by atomic absorption spectrophotometry. It was concluded that acute exposure to Cd has a somewhat different effect on Zn, Cu and Pb storage in the tissues than chronic exposure. It was further inferred that the effects on Zn, Cu and Pb cannot be used as diagnostic criteria in population screenings at very low doses of Cd.

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Section: Discussionsupporting

confidence: 95%

Section: Atomic Absorption Analysesmentioning

confidence: 99%

Effect of acute exposure to cadmium on zinc, copper and lead contents of hard and soft tissues of rats

Wesenberg

1983

International Journal of Environmental Studies

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“…When the Zn and Cu contents of the fossil teeth are compared with those of modern, ideally fed laboratory rats, the recorded levels may well represent those existing in the living animals [9,13,27]. At least there has been no influx of these elements during fossilization; if anything has changed postmortem, there must have been a slight leaching of the elements.…”

Section: Discussionmentioning

confidence: 97%

“…The rats, which were sacrificed at the age of 15 weeks, had been living on food pellets with an optimum concentration of Zn and Cu, 120 and 20/zg/g, respectively, and very low concentrations of the toxic elements, namely, 1.75/xg/g for lead and 0.3/xg/g for cadmium. Their drinking water was ordinary tap The processes protruding from the tubules have retained the bases of their branches water containing approximately 0.03 /xg/g Zn and 0.3 /xg/g Cu, and the concentrations of Pb and Cd were below the detection limit of the atomic spectrophotometer [12,13].…”

Section: Methodsmentioning

confidence: 99%

Microstructure and chemical composition of fossil mammalian teeth

1981

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Sectioned Cretaceous mammalian teeth were studied by light microscopy and SEM equipment with an electron microprobe. Structures resembling odontoblast processes were found. Their S/Fe ratio was similar to that of rat odontoblast processes, but the amounts of these elements were far higher than in processes of recent teeth. It was concluded that they consisted of pyrite, but their reaction with mercurochrome indicated presence of proteins with SH groups. Fluorescence microscopy indicated traces of collagen in the dentin. In the fossil enamel and dentin the Ca/P ratio was similar to that of recent teeth. Two samples of fossil teeth were analyzed for Pb, Cd, Zn, and Cu content by atomic absorption spectrophotometry. The levels of the latter two elements were normal, whereas that of Cd and especially that of Pb were higher than in laboratory rats. The probability that original protein fractions exist and that the different elements were those of the living animals is discussed.

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“…In 1E-7E there were five males and five females in b †In previous reports the designation CdCl 2 has erroneously been used for the batch of cadmium acetate that has been the source of supply throughout the series of different experiments with Cd aministration described by this author. l2, 14,[29][30][31] Regrettably, once introduced the error has hitherto escaped our attention. a = 5 ppm Cd in drinking water b = tap water Test groups 1-5: The rats sacrificed 15 weeks old.…”

Section: Experimental Conditionsmentioning

confidence: 96%

Cadmium content of indicators and target organs after acute Cd exposure

Wesenberg

1983

International Journal of Environmental Studies

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Eleven groups of Wistar rats were given 5 ppm cadmium acetate in the drinking water at different, interrupted periods of their life, simulating acute exposure. The Cd levels of indicators as hair, blood and teeth, and target organs as soft tissues and bone, were recorded by atomic absorption spectrophotometry. It was concluded that Cd passes the placental and mammary barriers; as regards the distribution of Cd in the tissues, the results confirmed previous findings. The results confirmed that rat molars are the best indicator and the most consistent one for past as well as present exposures in rats, but that hair can also be used to some extent as an indicator. The results further indicated that the administration of Cd alone resulted in a lower Cd residue than when Cd was administered concurrently with Pb.

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The effect of Pb and Cd uptake on Zn and Cu levels in hard and soft tissues of rats†

Cited by 5 publications

References 38 publications

Effect of acute exposure to cadmium on zinc, copper and lead contents of hard and soft tissues of rats

Effect of acute exposure to cadmium on zinc, copper and lead contents of hard and soft tissues of rats

Microstructure and chemical composition of fossil mammalian teeth

Cadmium content of indicators and target organs after acute Cd exposure

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