The Effect of Patho-biological Factors on the Survival of Recurrent Breast Cancer Patients

Abstract

Introduction: The recurrence of breast cancer after treatment is a loco-regional or distant metastasis recurrent. Although patients with metastasis are known as incurable, existing treatments might prolong patients› life while improving its quality. This is possible through identifying effective survival factors. This study evaluates the factors influencing survival after recurrence in recurrent breast cancer patients. Materials and Methods:This study was performed on 442 recurrent breast cancer patients who had been referred to the Cancer Research Center of the Shahid Beheshti University between 1985 to 2015. After confirming the recurrence as a distant metastasis or loco-regional recurrence, the effects of demographic, clinic-pathologic, biological, type of surgery and type of adjuvant treatments on the survival of patients were evaluated through statistical analysis. Results: The mean survival after recurrence was 18 months (5 days to 13 years), 219 patients (70.42%) survived two years, 75 patients (24.12%) survived from 2 to 5 years, and 17 patients (5.47%) survived more than 5 years. In this study, it was found through a univariate analysis that the factors of age, lymph node status, DFI, place of recurrence and nodal ratio are the most effective on survival after recurrence. Yet, in multivariate analysis, the most important factors influencing survival after recurrence included the place of recurrence and the lymph node status. Conclusions:The results of this study can enhance our knowledge in better understanding the effects of different factors on survival of patients after breast cancer recurrence, thus, it might be effective in treatment of patients before and after recurrence.

Breast Cancer Recurrence Survival Among Iranian Patients; A 17-Year Retrospective Cohort Study

“…It also showed that bone metastasis had more mortality than loco-regional metastasis. In our study, visceral metastasis similarly has the worst prognosis and the lowest survival however there are different results in various articles performed on this subject which could possibly be related to the sample size and group of patients that have been analyzed 26 regarding bone metastasis; our trial demonstrated that bone metastasis has better prognosis almost among other subtypes and in fact it has best survival following to local metastasis which could show the contrast between our study and other studies. Sta et al 20 showed that factors mentioned above as prognostic factors or related factors to recurrent and survival of patients with breast cancer are also correlated with metastasis of breast cancer.…”

Survival analysis of recurrent breast cancer patients using mix Bayesian network

“…Conversely, factors such as age, disease stage, tumor size, surgical method (MRM compared to BCS), and the presence of HER2 receptor, TNBC, and luminal B subtype (compared to luminal A subtype) were not found to have a statistically significant effect on patient survival. The survival rate of patients experiencing visceral recurrence is comparatively lower in comparison to those with local and bone recurrence [ 38 ].…”