The Effect of Passive Immunization Against Somatostatin on Marker Retention Time in Lambs

Fadlalla, A. M.; Spencer, G. S. G.; Lister, D.

doi:10.2527/jas1985.611234x

Cited by 30 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Improvements in digesta flow and nutrient utilization in SRIF-immunized animals have been reported in some studies (Fadlalla et al, 1985;Sun et al, 1990). Some evidence for improved food: gain ratios in immunized animals was obtained in the present study but not in immunized animals receiving cimaterol.…”

Section: Discussionsupporting

confidence: 47%

The effect of immunization against somatostatin and β-agonist administration alone and in combination on growth and carcass composition in young steers

et al. 1997

View full text Add to dashboard Cite

The effect of active immunization against somatostatin and ^-agonist administration alone and in combination on growth, carcass composition and endocrine responses was investigated in young steers given a pelleted diet of dried grass and barley (0-7: 0-3) ad libitum for 16 weeks. Immunization alone increased growth rate by proportionately 0-10 but had no effect on plasma growth hormone (GH) or insulin-like growth factor-1 (IGF-1) concentrations (P > 0-10). Carcass protein content was unchanged but fat content tended to be increased. This was possibly associated with increased (P < 0-10) plasma insulin concentrations observed in these animals. Cimaterol administration significantly increased growth rate (P < 0-05) and carcass weight (P < 0-01). Carcass protein content was significantly (P < 0-01) increased and carcass fat was significantly (P < 0-001) reduced. Administration of cimaterol to immunized animals resulted in an enhancement of the repartitioning effect of the pagonist although growth rates were intermediate between the separate treatments. The mechanism by which this was achieved is unclear. Plasma IGF-1 concentrations tended (P < 0-10) to be lower in these animals compared with controls. Plasma insulin concentrations were also reduced (P < 0-05) in these animals. Both immunized animals and those given cimaterol alone showed an increased GH response to a single intravenous injection of growth hormone releasing factor (GRF) (P < 0-05). Animals given the combined treatment however showed a reduced response suggesting that the effects were not mediated through direct changes in GH secretion. The improved lean :fat ratio in the carcass was observed to be mediated through an enhancement of the lipolytic response to the /Jagonist with only small effects on protein accretion. It is suggested that immunoneutralization of somatostatin may increase the sensitivity of adipose tissue to lipolytic stimuli. This could occur through changes in the secretion of gastrointestinal or pancreatic hormones as a result of neutralization of the inhibitory influences of somatostatin. Further work is required to clarify these effects.

show abstract

Section: Discussionsupporting

confidence: 47%

The effect of immunization against somatostatin and β-agonist administration alone and in combination on growth and carcass composition in young steers

et al. 1997

View full text Add to dashboard Cite

show abstract

“…The lack of response of the basal concentration of GH to SRIF immunization in this study and a number of others (Spencer & Williamson, 1981;Bass et al 1983;Spencer et al 19836;Chaplin, Kerr & Laarveld, 1984) may indicate that the somatomedin and growth re¬ sponses are not necessarily directly related to plasma concentrations of GH. Immunization against SRIF has also been shown to affect the alimentary tract by increasing plasma concentrations of triglycérides in dogs (Schusdziarra, Zyzhar & Rouiller, 1980) and slowing the flow of digesta in sheep (Fadalla, Spencer & Lister, 1985). The effects of SRIF immunization on the alimentary tract may have an indirect effect on growth and IGF-I production by possibly affecting nutritional availability from the gut.…”

Section: Discussionmentioning

confidence: 97%

Effect of nutrition and immunization against somatostatin on growth and insulin-like growth factors in sheep

Bass¹,

Gluckman²,

Fairclough³

et al. 1987

Journal of Endocrinology

View full text Add to dashboard Cite

The effect of immunizing against somatostatin (SRIF), with SRIF conjugated to bovine thyroglobulin, was examined in cross-bred sheep fed either cut pasture or lucerne pellets. Plasma concentrations of GH were unaffected by SRIF immunization, but were lower in pellet-fed sheep. Plasma concentrations of insulin-like growth factor I (IGF-I) increased after immunization in sheep on both diets. Pasture-fed sheep had lower plasma concentrations of IGF-I than those on pellets. Sheep showed a small increase in growth rate in response to immunization. Immunization had no effect on carcass composition and did not affect plasma concentrations of IGF-II, free fatty acids or glucose. The results show that even though SRIF immunization increases plasma concentrations of IGF-I, it does not necessarily result in a large increase in growth rate.

show abstract

“…Its mechanisms are as yet undetermined. Immunization against SRIH has been shown to slow gut motility in sheep (Fadalla et al 1985) and it may influence IGF-I synthesis and possibly growth by affecting the availability of nutri¬ ents from the digestive system. Anti-SRIH immunization may also stimulate the secretion of gastrointestinal peptides and as a consequence reduce food intake and liver IGF-I production which is under nutritional control .…”

Section: Discussionmentioning

confidence: 99%

Effect of actively immunizing sheep against growth hormone-releasing hormone or somatostatin on spontaneous pulsatile and neostigmine-induced growth hormone secretion

Magnan¹,

Mazzocchi²,

Cataldi³

et al. 1995

Journal of Endocrinology

View full text Add to dashboard Cite

The physiological role of endogenous circulating GH-releasing hormone (GHRH) and somatostatin (SRIH) on spontaneous pulsatile and neostigmine-induced secretion of GH was investigated in adult rams actively immunized against each neuropeptide. All animals developed antibodies at concentrations sufficient for immunoneutralization of GHRH and SRIH levels in hypophysial portal blood. In the anti GHRH group, plasma GH levels were very low; the amplitude of GH pulses was strikingly reduced, although their number was unchanged. No stimulation of GH release was observed after neostigmine administration. The reduction of GH secretion was associated with a decreased body weight and a significant reduction in plasma IGF-I concentration. In the anti-SRIH group, no changes in basal and pulsatile GH secretion or the GH response to neostigmine were observed as compared to controls. Body weight was not significantly altered and plasma IGF-I levels were reduced in these animals. These results suggest that in sheep, circulating SRIH (in the systemic and hypophysial portal vasculature) does not play a significant role in pulsatile and neostigmine-induced secretion of GH. The mechanisms of its influence on body weight and production of IGF-I remain to be determined.

show abstract

The Effect of Passive Immunization Against Somatostatin on Marker Retention Time in Lambs

Cited by 30 publications

References 0 publications

The effect of immunization against somatostatin and β-agonist administration alone and in combination on growth and carcass composition in young steers

The effect of immunization against somatostatin and β-agonist administration alone and in combination on growth and carcass composition in young steers

Effect of nutrition and immunization against somatostatin on growth and insulin-like growth factors in sheep

Effect of actively immunizing sheep against growth hormone-releasing hormone or somatostatin on spontaneous pulsatile and neostigmine-induced growth hormone secretion

Contact Info

Product

Resources

About