The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs

Mosharraf, Mitra; Nyström, Christer

doi:10.1016/0378-5173(95)00033-f

Cited by 332 publications

(197 citation statements)

References 15 publications

Supporting

Mentioning

188

Contrasting

Unclassified

Order By: Relevance

“…Este fenômeno é especialmente pronunciado em materiais com tamanho de partícula inferior a 5 µm. (Mosharraf, Nystrom, 1995). Além disso, é necessário delinear ensaios de dissolução que possam predizer, de forma mais eficaz, o comportamento in vivo das formas farmacêuticas.…”

Section: Introductionunclassified

Teste de dissolução para avaliação de liberação de glibenclamida em comprimidos

Nery

Pianetti

Pires

et al. 2007

Rev. Bras. Cienc. Farm.

View full text Add to dashboard Cite

A glibenclamida (GLIB) INTRODUÇÃOO diabetes mellitus (DM) é uma doença crônica, herdada ou adquirida, que atinge todas as faixas etárias. É causada pela deficiência ou ineficiência na produção de insulina pelo pâncreas e pode ser classificada, clinicamente, como tipo I ou tipo II, sendo que o último prevalece em 90% dos casos (WHO, 2002).O DM é um sério problema de saúde pública em praticamente todos os países e implica em elevado impacto sócioeconômico. Além dos elevados custos envolvidos no controle da doença e tratamento das complicações agudas e crônicas associadas, leva à incapacidade física permanente por cegueira e/ou amputação de membros e modifica a qualidade e a expectativa de vida do indivíduo. Até 2025, estima-se que 300 milhões de pessoas possuam a doença em todo o mundo (AHFS, 2000; WHO, 2002).Em 1998, o DM foi a sétima causa de morte no Brasil. Em 2001, a Campanha Nacional de Detecção de Diabetes rastreou, pela primeira vez no país, os suspeitos do diabetes. De 20,23 milhões de pessoas examinadas, 14,67% apresentaram suspeita da doença.

show abstract

Section: Introductionunclassified

Teste de dissolução para avaliação de liberação de glibenclamida em comprimidos

Nery

Pianetti

Pires

et al. 2007

Rev. Bras. Cienc. Farm.

View full text Add to dashboard Cite

show abstract

“…It is assumed that The Trivedi Effect ® might act as an external force like ball milling for reducing the particle size of pyridoxine HCl. The literature reported that a pharmaceutical solid compound having reduced particle size and crystallinity with the increased surface area possesses improved solubility dissolution rate, and finally bioavailability [32][33][34]. Thus, it is anticipated that The Trivedi Effect ® -Energy of Consciousness Healing Treated pyridoxine hydrochloride might offer better bioavailability than the untreated sample.…”

Section: Particle Size Analysis (Psa)mentioning

confidence: 99%

Evaluation of the Effect of the Energy of Consciousness Healing Treatment on Physicochemical and Thermal Properties of Pyridoxine Hydrochloride

Branton¹

2017

AJPC

View full text Add to dashboard Cite

Pyridoxine hydrochloride is water-soluble B vitamin widely used for the prevention and treatment of vitamin B 6 deficiency and other several diseases. The aim of this study was to explore the effect of The Trivedi Effect ® -Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of pyridoxine hydrochloride using PXRD, PSA, DSC, and TGA/DTG analysis. Pyridoxine hydrochloride was divided into two parts, one part of pyridoxine hydrochloride was considered as control (no Biofield Treatment was provided), while second part received The Trivedi Effect ® -Biofield Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The PXRD analysis exhibited that the relative intensities and crystallite sizes of the most characteristic diffraction peaks in the Alice's treated pyridoxine hydrochloride were significantly decreased from 1.59% to 44.47% and 6.31% to 28.28%, respectively compared with the control sample. Overall, the average crystallite size of the treated sample was significantly reduced by 5.55% compared with the control sample. The particle size values at d 10 , d 50 , d 90 , and D(4, 3) (average mass-volume diameter) in Alice's treated sample were significantly reduced by 13.87%, 9.95%, 7.87%, and 6.59%, respectively compared to the control sample. The specific surface area of treated sample was significantly increased by 13.67% compared to the control sample. The DSC analysis revealed that the melting point of the treated sample was lower by 0.20% with a significant reduction of the latent heat of fusion by 24.52% compared with the control sample. The TGA analysis revealed that the total weight loss in the treated sample was increased by 1.76% compared with the control sample. The DTG analysis indicated that the maximum thermal degradation temperature of the treated sample was reduced by 0.88% compared to the control sample. Overall, the thermal analysis indicated that the thermal stability of the treated pyridoxine hydrochloride was declined compared to the control sample. Thus, The Trivedi Effect ® might lead to the production of a polymorphic form of pyridoxine hydrochloride which would be more soluble, absorbable, have a higher dissolution rate and be more bioavailable compared with the untreated sample. The Biofield Energy Treated pyridoxine hydrochloride would be beneficial in the design of better nutraceutical and pharmaceutical formulations which might provide better therapeutic responses against vitamin B 6 deficiency,

show abstract

“…Particle size and the surface area have a major effect on dissolution of a compound in a solvent, because the surface energy influenced by surface area and chemical affinity is the driving factor for dissolution efficiency [48][49][50]. Kale et al [51] reported that introduction of the external force leads to the transform the fine particles into larger particles.…”

Section: Particle Size Distribution (Psd) Analysismentioning

confidence: 99%

Physicochemical, Thermal, Structural, and Behavioral Properties Analysis in Magnesium Gluconate: An Effect of the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

Trivedi¹,

Branton²,

Trivedi³

et al. 2017

IJBMR

View full text Add to dashboard Cite

Abstract:Magnesium gluconate is an organometallic pharmaceutical/nutraceutical used for the prevention and treatment of various diseases caused by the low level of magnesium. The aim of the present study was to investigate the influence of The Trivedi Effect ® -Energy of Consciousness Healing Treatment (Biofield Energy Healing) on the physicochemical, thermal, structural, and behavioral properties of magnesium gluconate using powder PXRD, PSD, FT-IR, UV-visible, TGA, and DSC analysis. Magnesium gluconate was divided into two parts -one part was denoted as the control, while the another part was treated with The Trivedi Effect ® remotely by eighteen renowned Biofield Energy Healers and defined as the Trivedi Effect ® Treated sample. The PXRD analysis exhibited the significant alteration of the crystal morphology of the treated sample compared with the control sample. The crystallite size of the treated sample was significantly altered from -39.99% to 62.57% compared with the control sample. The average crystallite size of the treated sample was decreased by 9.71% compared with the control sample. Particle size of the treated sample at d 10 , d 50 , and d 90 value was significantly increased by 5.36%, 23.10% and 11.11%, respectively compared with the control sample. The surface area of the treated sample was significantly decreased by 9.76% compared to the control sample. The FT-IR and UV-vis analysis showed that the structural characteristic of the magnesium gluconate remained same in the treated sample compared with control sample. The TGA data revealed that the weight loss of the treated sample in the first and third steps of degradation was increased by 31.58% and 5.94%, respectively, whereas in the second step of degradation, the weight loss was decreased by 7.57% compared with the control sample. The DSC analysis showed that the melting point of the control and treated samples were at 170.29°C and 169.76°C, respectively. The latent heat of fusion of the treated sample was increased by 4.18% compared with the control sample. The current study evaluated that The Trivedi Effect ® -Energy of Consciousness Healing Treatment might lead to a new polymorphic form of the magnesium gluconate, which could be more soluble, powder flowability and long-term storage stability compared with the control sample. Hence, the Trivedi Effect ® Treated magnesium gluconate would be very useful to design better nutraceutical and/or pharmaceutical formulations that might provide better therapeutic response against inflammatory diseases, immunological disorders, and other chronic infections.

show abstract

The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs

Cited by 332 publications

References 15 publications

Teste de dissolução para avaliação de liberação de glibenclamida em comprimidos

Teste de dissolução para avaliação de liberação de glibenclamida em comprimidos

Evaluation of the Effect of the Energy of Consciousness Healing Treatment on Physicochemical and Thermal Properties of Pyridoxine Hydrochloride

Physicochemical, Thermal, Structural, and Behavioral Properties Analysis in Magnesium Gluconate: An Effect of the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)

Contact Info

Product

Resources

About

The effect of particle size and shape on the surface specific dissolution rate of microsized practically insoluble drugs

Cited by 332 publications

References 15 publications

Teste de dissolução para avaliação de liberação de glibenclamida em comprimidos

Teste de dissolução para avaliação de liberação de glibenclamida em comprimidos

Evaluation of the Effect of the Energy of Consciousness Healing Treatment on Physicochemical and Thermal Properties of Pyridoxine Hydrochloride

Physicochemical, Thermal, Structural, and Behavioral Properties Analysis in Magnesium Gluconate: An Effect of the Energy of Consciousness (The Trivedi Effect&lt;sup&gt;®&lt;/sup&gt;)

Contact Info

Product

Resources

About

Physicochemical, Thermal, Structural, and Behavioral Properties Analysis in Magnesium Gluconate: An Effect of the Energy of Consciousness (The Trivedi Effect<sup>®</sup>)