The effect of partial substitution of chloride by bromide in the 0-D hybrid material (C4H12N2)[CuCl4]·2H2O: Structural, vibrational, thermal, in silico and biological characterizations

Derbel, Marwa Abid; Jlassi, Raja; Roisnel, Thierry; Badraoui, Riadh; Krayem, Najeh; Al-Ghulikah, Hanan A.; Rekik, Walid; Naı̈li, Houcine

doi:10.1080/00958972.2022.2157722

Cited by 7 publications

(1 citation statement)

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“…In addition, different magnetic behaviors varying from ferro-to antiferromagnetic interactions of manganese (II) complexes were proven [18,19]. It is shown in the literature that inorganic-organic hybrid complexes play an important role in medicinal chemistry [20][21][22]. For instance, these components have wide application in drugs synthesis.…”

Section: Introductionmentioning

confidence: 99%

Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl4(H2O)2]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation

et al. 2023

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A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C5H14N2)[MnCl4(H2O)2] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl4(H2O)2]2−. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses.

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