“…McGue and colleagues (1997; found that alcohol dependence is particularly common among individuals who have high levels of both behavioral disinhibition and negative emotionality and that alcohol dependence is primarily associated with negative emotionality, while illicit drug use disorders are primarily associated with constraint (McGue, Slutske, & Iacono, 1999;McGue, Slutske, Taylor, & Iacono, 1997). Similarly, Elkins et al (2004) found that adolescent offspring of parents with a history of alcohol dependence scored significantly higher on negative emotionality than adolescents with no parental history of alcohol dependence, and negative emotionality did not differ for offspring of parents with and without a drug abuse/dependence history (Elkins, McGue, Malone, & Iacono, 2004). They found that this pattern characterized both offspring with an SUD and those who had not yet developed an SUD, which supports negative emotionality as an indicator of familial risk for alcoholism.…”