The Effect of Parathion on Mouse Testicular and Epididymal Development Cultured in Chicken Allantochorion

Rojas, Mariana; Bustos‐Obregón, Eduardo; Martínez-García, Francisco; Contreras, Héctor R.; Regadera, Javier

doi:10.1007/978-1-4899-0089-0_23

Cited by 13 publications

(4 citation statements)

References 7 publications

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“…Similar impairment of spermatogenesis was reported by previous findings for other categories of pesticides such as DBCP, 10 dioxin, 11 carbofuran, 12 lindane, 13 kepone 14 and parathion. 15 The weight of the seminal vesicles of rats exposed to DDT are significantly reduced. This result is in accord with previous reports found in response to DDE 16 and postulated to be mediated in part by the antiandrogenic activity of this compound.…”

Section: Discussionmentioning

confidence: 98%

Reproductive toxicity of DDT in adult male rats

Rhouma¹,

Tebourbi²,

Krichah³

et al. 2001

Hum Exp Toxicol

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The reproductive toxicity of DDT was investigated in adult male rats exposed to 50 and 100 mg/kg body weight (b.wt) day 1 for 10 successive days. Compared with control animals, administration of DDT led to a dose-dependent reduction of testicular weight and the number as well as the percentage of motile spermatozoa in the epididymis. Testicular histological observationsrevealed alsoamarkedloss of gametes in the lumen of seminiferous tubules. In DDT treated rats, the seminal vesicles weights dropped significantly, resulting from a decrease of testosterone production by testes, whereas serum LH and FSH increased after pesticide exposure. This increase of gonadotrophin levels may be related to an impairment of the negative feedback exerted by the steroid on the hypothalamic–pituitary axis. It is concluded that DDT induced adverse effects on male rat fertility by acting directly on the testes and altering the neuroendocrinefunction.

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Section: Discussionmentioning

confidence: 98%

Reproductive toxicity of DDT in adult male rats

Rhouma¹,

Tebourbi²,

Krichah³

et al. 2001

Hum Exp Toxicol

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“…Studies in pregnant rats demonstrated that diazinon is potentially mutagenic, embryotoxic and teratogenic in vivo (38). Our group also studied the effect of parathion on mouse testicular and epididymal development using an "old but novel" approach by culturing these organs in chicken allantochorion (39). We found no malformations of the chicken embryos in low doses of parathion (0.5 or 1.0 mg/ml).…”

Section: Organophosphorous Agropesticides (Op): Some General Biologicmentioning

confidence: 93%

Adverse effects of exposure to agropesticides on male reproduction

Bustos‐Obregón

2001

APMIS

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Adverse effects of chemical pollutants on spermatogenesis have become a relevant issue in modern andrology, since environmental chemical contamination increases everyday world‐wide. Agropesticides are one important group of such chemicals. Their relevance is due to their widespread use, mostly in the Third World, and to the various ways they interfere with male reproduction. Most organochlorine pesticides behave as xenoestrogens and though they have been banned in most countries many years ago, they have long lasting effect in the biosphere and are still illegally used. They have been largely replaced by organophosphorous pesticides (OP) which since then have been demonstrated as hazardous to human reproduction. This article provides a brief review on agropesticides, their use in Latin America, and occupational and environmental risks. Some of the clinical and biological effects of an OP pesticide parathion are presented. Animal experiments showed that OP chemicals damage germ and somatic cells of the testis, both at the onset of spermatogenesis and in the adults. Effects are not only genotoxic, but also teratogenic. The present knowledge advices prompt replacement of chemical pest control by environmentally safer methods.

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“…4-Nitrophenol, a metabolite of parathion, was also estrogenic and antiandrogenic in in vivo uterotrophic and Hershberger assays (Li et al, 2006b). Parathion was reported to interfere with mouse spermatogenesis by suppressing normal testicular differentiation (Rojas et al, 1998). Contreras et al (2006) reported that parathion disturbs the synthesis of testosterone in mice, qualitatively affecting spermatogenesis.…”

Section: Androgen-related Endocrine Effectmentioning

confidence: 99%