The effect of paracorporeal pulsatile biventricular assist devices on allosensitization in adults: A comparison with left ventricular assist devices

Chaidaroglou, Antigoni; Armenis, Iakovos; Gkouziouta, A.; Bonios, Michael; Kogerakis, Nektarios; Fragoulis, Socrates; Leontiadis, Evangelos; Zarkalis, D.; Stavridis, George; Kaklamanis, Loukas; Adamopoulos, Stamatis; Degiannis, Dimitrios

doi:10.1016/j.trim.2021.101477

Cited by 4 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of HTx candidiates with allosensitization at a high titer of pre-formed HLA-antibodies has doubled over the last decades [43,87] and becomes more and more an obstacle to donor heart allocation. It affects between 6% to 9.2% of all HTx candidates, and while an earlier series of patients on LT-MCS reported a prevalence of allosensitization in up to two thirds of their patients [88], a contemporary series indicates a lower rate of 11% in patients on pulsatile LT-MCS and 15% in those on continuous-flow support [89]. However, allosensitization represents a threat to HTx programs since the number of BTT patients on the waitlist is increasing [76].…”

Section: Heart Transplantationmentioning

confidence: 97%

Cardiac Surgery in Advanced Heart Failure

Hullin

Meyer

Yerly

et al. 2022

JCM

View full text Add to dashboard Cite

Mechanical circulatory support and heart transplantation are established surgical options for treatment of advanced heart failure. Since the prevalence of advanced heart failure is progressively increasing, there is a clear need to treat more patients with mechanical circulatory support and to increase the number of heart transplantations. This narrative review summarizes recent progress in surgical treatment options of advanced heart failure and proposes an algorithm for treatment of the advanced heart failure patient at >65 years of age.

show abstract

Section: Heart Transplantationmentioning

confidence: 97%

Cardiac Surgery in Advanced Heart Failure

Hullin

Meyer

Yerly

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…The results with biventricular Berlin Heart EXCOR support presented here shed light on the feasibility of this surgical approach and the noninferior survival rate post-HTX in patients with a BIVAD compared to HTX patients with an HTX without previous VAD therapy [ 7 , 8 ]. Between 2006 and 2020, we implanted 250 permanent MCS devices in patients seen at our centre (BIVAD = 58, HeartWare ventricular assist device = 83, HeartMate II = 5, HeartMate 3 = 104).…”

Section: Discussionmentioning

confidence: 86%

“…Pump thrombosis, wound infections and bleeding are the main complications while the patient is on VAD support [ 13 ]. The most recent studies on BIVAD in adults included 80 patients on the Berlin Heart EXCOR [ 7 , 8 ]. Wound infections in patients who have the Berlin Heart EXCOR are discussed mainly in paediatric subpopulations.…”

Section: Discussionmentioning

confidence: 99%

“…The European Registry for Patients with Mechanical Circulatory Support report on primary biventricular support from 2019 included only 5 adult patients with the Berlin Heart EXCOR [ 6 ]. Recently, 2 larger studies of adults support by a paracorporeal pulsatile BIVAD showed good survival rates and highlighted the challenges of long-term support [ 7 , 8 ]. One study focuses on allosensitization in adults before an HTX without further description of adverse events [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, 2 larger studies of adults support by a paracorporeal pulsatile BIVAD showed good survival rates and highlighted the challenges of long-term support [ 7 , 8 ]. One study focuses on allosensitization in adults before an HTX without further description of adverse events [ 7 ]. The second study by Michel et al presents an outcome evaluation of patients in beginning cardiogenic shock who were bridged to an HTX with the Berlin Heart EXCOR [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-term paracorporeal pulsatile mechanical circulatory support in adolescent and adult patients

Kremer

Sommer

et al. 2022

Interactive CardioVascular and Thoracic Surgery

View full text Add to dashboard Cite

Objectives Our study objective was to analyse adverse events in adolescent and adult Berlin Heart EXCOR patients and to assess outcome of subsequent heart transplantation (HTX) Methods From 2006 to 2020, 58 patients (12–64 years) received a biventricular assist device (BIVAD) at our institution and were included in this study. Results Causes of biventricular heart failure were non-ischaemic cardiomyopathy (62.1%), ischaemic cardiomyopathy (22.4%) and myocarditis (15.5%). Median INTERMACS score was I (I—III). Median age was 49 years (IQR 34–55 years) and 82.8% were male. Causes of death were: multi-organ failure (25.0%), septic shock (17.9%), cerebral haemorrhage (14.3%), bleeding (14.3%) and embolic events (14.3%). Major bleedings were more frequent in the group who died on BIVAD (60.7 vs 6.7%, p < 0.001). Wound infections were more prevalent in HTX recipients (n = 21, 70.0%). After BIVAD thrombosis, 104 chamber exchanges were performed in 28 patients (48.3%). HTX was performed in 52.6% of the patients after BIVAD support time 316 ± 240 days. Mean time to follow-up of 30 HTX recipients was 1722 ± 1368 days. One-, 6- and 12-month-survival after heart transplantation were 96.7%, 90.0% and 76.7% respectively. Long-term survival after 5 and 10 years was 69.7%. Conclusions Pump thrombosis, infections and bleeding after BIVAD did not preclude successful HTX. Although only 50% of BIVAD patients were successfully transplanted, long-term survival after HTX in BIVAD patients was non-inferior when compared to other recipients.

show abstract

Immunologic Responses Post Mechanical Circulatory Support Device Implantation

Zhang¹,

Reinsmoen²

2023

Mechanical Circulatory Support

View full text Add to dashboard Cite

The effect of paracorporeal pulsatile biventricular assist devices on allosensitization in adults: A comparison with left ventricular assist devices

Cited by 4 publications

References 30 publications

Cardiac Surgery in Advanced Heart Failure

Cardiac Surgery in Advanced Heart Failure

Long-term paracorporeal pulsatile mechanical circulatory support in adolescent and adult patients

Immunologic Responses Post Mechanical Circulatory Support Device Implantation

Contact Info

Product

Resources

About