The Effect of Paracetamol and Codeine Analgesic Combination on Creatinine Levels in Male Wistar Rats

Natasaputra, Vianney; Nugroho, Taufik Eko

doi:10.14710/dimj.v1i1.7833

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…However, acetaminophen can be equally harmful for the kidneys, giving rise to AKI when ingested in toxic amounts 13 . Various mechanisms of kidney injury may be involved, such as chronic interstitial inflammation and fibrosis, thickening of the vascular wall in the kidney, renal papilla necrosis, and cortex necrosis 14 . The mechanisms of necrosis in both organs are similar, yet there are some subtle differences that remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Nephrotoxicity by overdose of acetaminophen

GJERMENI¹,

NELAJ²,

KECAJ³

et al. 2021

Arch Balk Med Union

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Néphrotoxicité par surdosage d'acétaminophèneIntroduction. L'acétaminophène (paracétamol) est un médicament largement utilisé et connu comme un analgésique et antipyrétique sûrs. L'hépatotoxicité est généralement la première complication d'une surdose d'acétaminophène. La néphrotoxicité apparaît généralement après une toxicité hépatique. La plupart des études sur ce sujet se sont concentrées sur des cas de surdosage aigu d'acétaminophène, avec moins d'études sur les effets d'un surdosage chronique. Présentation du cas. Nous présentons le cas d'une femme de 74 ans souffrant d'insuffisance rénale aiguë à cause d'un surdosage chronique d'acétaminophène et une mini revue de la littérature. Le patient s'est présenté aux urgences pour confusion, avec altération des paramètres vitaux. Elle avait utilisé régulièrement 5 à 6 g/jour de paracétamol au cours des 4 semaines précédentes en raison de douleurs articulaires. Une insuffisance rénale et hépatique aiguë a été diagnostiquée. Après un traitement spécifique, le patient est sorti en bon état. Conclusions. Un historique approprié des médicaments administrés (y compris aussi ceux sans ordonnance du médecin) permet un diagnostic précis et permet une prise en charge thérapeutique plus rapide.

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Section: Discussionmentioning

confidence: 99%

Nephrotoxicity by overdose of acetaminophen

GJERMENI¹,

NELAJ²,

KECAJ³

et al. 2021

Arch Balk Med Union

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Evaluating The Adverse Health Effects of Herbal Medicine on Swiss Albino Mice: A Comprehensive Hepatotoxicity and Nephrotoxicity Analysis

Alom,

Zamir,

Islam

et al. 2024

Preprint

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Herbal medicine (HM) has been utilized extensively to a wide range of illnesses for thousands of years and has significantly contributed to the health of human beings. The harmful health consequences or degree of toxicity of herbal medication are not demonstrated according to testing, manufacturing, and labeling standards of Food and Drug Administration. The aim of the study was to investigate the hepatotoxicity and nephrotoxicity of herbal medicine - Amlasia: a well‑known Hamdard herbal formulation – on swiss albino mice. For fourteen days straight, the Amlasia solution was administered orally at two separate dosages (0.5 ml per kg and 2.5 ml per kg body weight). Paracetamol was employed for a single lethal dosage of hepato-renal toxicity and allopathic medications Maxpro were utilized as standard. Enzyme levels such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride, total protein (TP), bilirubin, albumin (ALB), blood urea nitrogen (BUN), creatinine, and urea were measured in order to evaluate liver and kidney impairment. Besides, oxidative stress markers (reduced glutathione, malondialdehyde, catalase activity) were assessed and finally, cellular toxicity level was evaluated through histopathology analysis. The outcomes for the parameters measuring liver and kidney function showed that, enzyme levels did not significantly change after Amlasia treatment. Moreover, the oxidative stress markers also indicate the non-significant difference as compared with saline control group. Finally, the histopathological analysis of the liver and kidney samples revealed normal cellular levels according to microscopic evaluation. The investigated herbal medicine did not cause hepatotoxic or nephrotoxic disorders in the experimented animals, according to biochemical parameter, oxidative stress marker and histological examination. It was concluded that, the investigated herbal medicine was therefore found to be pharmacologically safe.

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The Effect of Paracetamol and Codeine Analgesic Combination on Creatinine Levels in Male Wistar Rats

Cited by 2 publications

References 23 publications

Nephrotoxicity by overdose of acetaminophen

Nephrotoxicity by overdose of acetaminophen

Evaluating The Adverse Health Effects of Herbal Medicine on Swiss Albino Mice: A Comprehensive Hepatotoxicity and Nephrotoxicity Analysis

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