The Effect of para-Aminobenzoic Acid on Apoptosis Processes in the Adult Rat Conjunctiva and Corneal Epithelium in vivo after Hypobaric Hypoxia

Markitantova, Yu. V.; Akberova, S. I.; Ryabtseva, A. A.; Stroeva, O. G.

doi:10.1134/s1062359018020061

Cited by 10 publications

(2 citation statements)

References 17 publications

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“…Various compounds bearing a pABA nucleus exert strong antimicrobial [17,18], antimutagenic [19], antioxidant, cytoprotective [20], and immunomodulatory [21,22] properties. Moreover, various pABA derivatives have antineoplastic, anesthetic, antiarrhythmic, anticonvulsant, antiemetic, and gastrokinetic [16,23] properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Sapijanskaitė-Banevič

Palskys

Vaickelionienė

et al. 2021

Molecules

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The p-aminobenzoic acid was applied for the synthesis of substituted 1-phenyl-5-oxopyrrolidine derivatives containing benzimidazole, azole, oxadiazole, triazole, dihydrazone, and dithiosemicarbazide moieties in the structure. All the obtained compounds were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Salmonella enteritidis, Escherichia coli, and Pseudomonas aeruginosa by using MIC and MBC assays. This study showed a good bactericidal activity of γ-amino acid and benzimidazoles derivatives. The antimicrobial activity of the most promising compounds was higher than ampicillin. Furthermore, two benzimidazoles demonstrated good antimicrobial activity against L. monocytogenes (MIC 15.62 µg/mL) that was four times more potent than ampicillin (MIC 65 µg/mL). Further studies are needed to better understand the mechanism of the antimicrobial activity as well as to generate antimicrobial compounds based on the 1-phenyl-5-oxopyrrolidine scaffold.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Sapijanskaitė-Banevič

Palskys

Vaickelionienė

et al. 2021

Molecules

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“…PABA and its derivatives have been utilized as active constituents in sunscreens to protect against UVB irradiation, i.e., scavengers of reactive oxygen species [1][2][3]. PABA demonstrated also properties of cytoprotective agents [7] and direct anticoagulants [2]. PABA-based diagnostic tests of gastrointestinal tract state have been developed [4,8].…”

Section: Introductionmentioning

confidence: 99%

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents

et al. 2019

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4-aminobenzoic acid (PABA), an essential nutrient for many human pathogens, but dispensable for humans, and its derivatives have exhibited various biological activities. In this study, we combined two pharmacophores using a molecular hybridization approach: this vitamin-like molecule and various aromatic aldehydes, including salicylaldehydes and 5-nitrofurfural, via imine bond in one-step reaction. Resulting Schiff bases were screened as potential antimicrobial and cytotoxic agents. The simple chemical modification of non-toxic PABA resulted in constitution of antibacterial activity including inhibition of methicillin-resistant Staphylococcus aureus (minimum inhibitory concentrations, MIC, from 15.62 µM), moderate antimycobacterial activity (MIC ≥ 62.5 µM) and potent broad-spectrum antifungal properties (MIC of ≥ 7.81 µM). Some of the Schiff bases also exhibited notable cytotoxicity for cancer HepG2 cell line (IC 50 ≥ 15.0 µM). Regarding aldehyde used for the derivatization of PABA, it is possible to tune up the particular activities and obtain derivatives with promising bioactivities.

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Structure-forming non-covalent bonding of new 2-(4-carboxyphenylhydrazinylidene)[1,3]thiazolo[3,2-a]pyrimidines in the crystalline phase

Agarkov,

Mingazhetdinova,

Nefedova

et al. 2024

Russ Chem Bull

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The Effect of para-Aminobenzoic Acid on Apoptosis Processes in the Adult Rat Conjunctiva and Corneal Epithelium in vivo after Hypobaric Hypoxia

Cited by 10 publications

References 17 publications

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

Synthesis and Antibacterial Activity of New Azole, Diazole and Triazole Derivatives Based on p-Aminobenzoic Acid

4-Aminobenzoic Acid Derivatives: Converting Folate Precursor to Antimicrobial and Cytotoxic Agents

Structure-forming non-covalent bonding of new 2-(4-carboxyphenylhydrazinylidene)[1,3]thiazolo[3,2-a]pyrimidines in the crystalline phase

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