The Effect of Pan-Retinal Photocoagulation on Rubeosis Iridis

Little, Hunter L.; Rosenthal, A R; Dellaporta, A.; Jacobson, Douglas R.

doi:10.1016/0002-9394(76)90364-0

Cited by 116 publications

(34 citation statements)

References 9 publications

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“…Clinical studies show that the destruction of retinal elements by laser or xenon arc photocoagulative treatment results in the regression of untreated disk, retinal, and iris neovascularization (15,17,19). These studies suggest that, under certain conditions, retina can liberate a substance (or substances) capable of inducing intraocular neovascularization .…”

Section: Discussionmentioning

confidence: 99%

Demonstration of vasoproliferative activity from mammalian retina.

Glaser¹,

D’Amore²,

Michels³

et al. 1980

The Journal of Cell Biology

260

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Vasoproliferative activity has been demonstrated in extracts of retinas from human, bovine, and feline sources. These retinal extracts are capable of stimulating (a) proliferation and thymidine uptake of bovine vascular endothelial cells in culture and (b) neovascularization on the chick chorioallantoic membrane. Extracts of skeletal muscle, cardiac muscle, and liver lack similar stimulatory activity. The activity is nondialyzable, stable at 56 degrees C, and inactivated at 100 degrees C. Retinal extracts stimulate the proliferation of corneal fibroblasts but have no effect on the proliferation of vascular smooth muscle cells. Indirect evidence suggests the liberation of a vasoproliferative factor from retina in several ocular disorders. The data in this report represent the first direct demonstration of vasoproliferative activity from mammalian retina.

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Section: Discussionmentioning

confidence: 99%

Demonstration of vasoproliferative activity from mammalian retina.

Glaser¹,

D’Amore²,

Michels³

et al. 1980

The Journal of Cell Biology

260

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“…The mainstay of therapies, currently panretinal laser photocoagulation (PRP) and panretinal cryotherapy, are applied in order to prevent the formation of neovascularization especially in the angle region and to achieve regression of vessels that are already present in the anterior (and posterior) chamber [11,12]. Another very radical treatment option is retinal ablation.…”

mentioning

confidence: 99%

Treatment of Rubeosis iridis with Photodynamic Therapy with Verteporfin – A New Therapeutic and Prophylactic Option for Patients with the Risk of Neovascular Glaucoma?

Müller¹,

Ruokonen²,

Schellenbeck³

et al. 2003

Ophthalmic Res

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Patients with ischaemic retinopathy who show iris neovascularization despite panretinal laser photocoagulation (PRP) very often develop a neovascular glaucoma. Photodynamic therapy (PDT) has been shown to occlude neovascularization without damage to physiologic vessels or adjacent tissue in the treatment of choroidal neovascularization (CNV) and might also be of value for patients with neovascular glaucoma who did not benefit from the PRP. First results of a monocentre, open label, intra-individual controlled, pilot phase I/II, dose-finding study demonstrate that PDT with verteporfin is capable of occluding neovascular vessels for a defined period of time without damaging adjacent tissue or physiologic iris vessels. Whether this vessel occlusion will have an impact on the progression of rubeosis or neovascular glaucoma will be the subject of further investigation.

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“…While previous studies have shown that the early stages of neovasculariza tion can regress after laser treatment, they have dealt predominantly with diabetic eyes, and the number of eyes with central retinal vein occlusion studied in these reports is extremely small [3,[5][6][7][8]. What appears from one of these studies is the finding that eyes with angle closure of greater than 270° tend not to respond to panretinal photocoagula tion [5].…”

Section: Discussionmentioning

confidence: 62%

Efficacy of Panretinal Photocoagulation in Central Retinal Vein Occlusion

Gomolin

1989

Ophthalmologica

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This retrospective study reviews the efficacy of panretinal photocoagulation in the prevention and management of ocular neovascularization in 55 cases of central retinal vein occlusion. Differentiation of occlusions into ischemic and nonischemic forms is of critical importance, with aggressive laser treatment being warranted in the ischemic variety. The presence of ocular neovascularization may not necessarily imply a grim prognosis.

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The Effect of Pan-Retinal Photocoagulation on Rubeosis Iridis

Cited by 116 publications

References 9 publications

Demonstration of vasoproliferative activity from mammalian retina.

Demonstration of vasoproliferative activity from mammalian retina.

Treatment of Rubeosis iridis with Photodynamic Therapy with Verteporfin – A New Therapeutic and Prophylactic Option for Patients with the Risk of Neovascular Glaucoma?

Efficacy of Panretinal Photocoagulation in Central Retinal Vein Occlusion

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