Background
We examined the influence of depressed mood and psychological stress on oral contraceptive (OC) side effects and discontinuation.
Study Design
We administered standard psychological instruments to 354 young women (13–24 years) beginning a six-month OC continuation intervention trial and questions on OC side effects and use at six months. Logisitic regression determined the relationships between psychological conditions, perceived OC side effects and continuation rates.
Results
Baseline depressed mood (21%) and stress (19%) and six-month mood (25%) and weight changes (57%) were relatively common. Only 38% continued OCs at six months. Depressed mood (OR 2.27, CI 1.25–4.15, p=0.007) and stress (OR 2.07, CI 1.12–3.82, p=0.02) were associated with perceived OC-related moodiness; depressed mood was associated with perceived weight loss (OR 1.89, CI 1.01–3.55, p=0.05). Depressed mood (OR 0.54, CI 0.29–0.99, p=0.04), stress (OR 0.48, CI 0.25–0.91, p=0.03) and perceived weight change (OR 0.60, CI 0.38–0.94, p=0.03) all reduced the likelihood of OC continuation.
Conclusion
Young women with adverse psychological symptoms are at risk for perceived OC side effects and discontinuation.