The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction

Jb, Lassen

doi:10.1007/bf00421965

Cited by 36 publications

(12 citation statements)

References 37 publications

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“…Rats were injected with saline or PCA (10 mg/kg). In agreement with previous reports (Frey & Magnussen, 1968;Buus Lassen, 1974) the PCAtreated animals rapidly became hyperactive and behaviourally were identical to rats given tranylcypromine and L-tryptophan (Figure 2a). This effect lasted for over 2 h and will be discussed later.…”

Section: Methodssupporting

confidence: 92%

“…Therefore, when 5-HT is released it is not metabolized intraneuronally and 'spills-over' into the synaptic cleft producing stimulation of 5-HT receptors, explaining why the hyperactivity following PCA is identical to that seen after tranylcypromine/Ltryptophan administration; an observation also made by Jacobs, Mosko & Trulson (1976). It also explains why PCPA abolishes PCA-induced hyperactivity (Buus Lassen, 1974;Jacobs etat., 1976). a-Methylptyrosine blocks PC A-induced hyperactivity (Buus Lassen, 1974) and 5-HT-induced hyperactivity is also inhibited by this drug (Green & Grahame-Smith, 1974b).…”

Section: Discussionmentioning

confidence: 93%

“…It also explains why PCPA abolishes PCA-induced hyperactivity (Buus Lassen, 1974;Jacobs etat., 1976). a-Methylptyrosine blocks PC A-induced hyperactivity (Buus Lassen, 1974) and 5-HT-induced hyperactivity is also inhibited by this drug (Green & Grahame-Smith, 1974b).…”

Section: Discussionmentioning

confidence: 97%

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EVIDENCE CONCERNING THE INVOLVEMENT OF 5‐HYDROXYTRYPTAMINE IN THE LOCOMOTOR ACTIVITY PRODUCED BY AMPHETAMINE OR TRANYLCYPROMINE PLUS l‐DOPA

Green¹,

Kelly

1976

British J Pharmacology

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I Pretreatment of rats with p-chlorophenylalanine (PCPA; 2 x 200 mg/kg) decreased the concentration of 5-hydroxytryptamine (5-HT) in the brain. It also decreased the locomotor activity produced by tranylcypromine plus L-DOPA administration 24 h after the second dose of PCPA. 2 Pretreatment with p-chloroamphetamine, which produced a similar decrease in brain 5-HT concentrations did not decrease the locomotor response to tranylcypromine and L-DOPA. 3 PCPA pretreatment decreased the rise in the concentration of DOPA and dopamine in the brain following tranylcypromine and L-DOPA, suggesting its effect on the dopamine-induced locomotor activity was the result of this drug diminishing dopamine formation in the brain, probably by inhibiting L-DOPA uptake. 4 The locomotor activity produced by tranylcypromine and L-DOPA was not decreased by pretreatment 6 h earlier with disulfiram (400 mg/kg). This argues against the locomotor activity being due to noradrenergic stimulation. 5PCPA pretreatment did not alter amphetamine-induced stereotypy or the circling behaviour in unilateral nigro-striatal lesioned rats.

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Section: Methodssupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%

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EVIDENCE CONCERNING THE INVOLVEMENT OF 5‐HYDROXYTRYPTAMINE IN THE LOCOMOTOR ACTIVITY PRODUCED BY AMPHETAMINE OR TRANYLCYPROMINE PLUS l‐DOPA

Green¹,

Kelly

1976

British J Pharmacology

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“…Paroxetine is a phenylpiperidine compound ( Figure 1) which has been shown, in vitro and in animals, to be a selective 5-hydroxytryptamine (5-HT) uptake inhibitor (Lassen, 1974). Early clinical studies have indicated that it is an effective antidepressant with few side effects (Borup et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.

Hassan¹,

Wainscott²,

Turner³

1985

Brit J Clinical Pharma

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“…Fenfluramine and PCA-induced behavioural syndromes occur as a result of fenfluramine and PCA being taken up into 5-HT neurones and releasing 5-HT (Buus-Lassen 1974;Trulson and Jacobs 1976). Clomipramine and other 5-HT uptake blockers antagonize the behavioural effects of fenfluramine and PCA by blocking their entry into the 5-HT neurones and preventing the subsequent release of 5-HT (Buus-Lassen 1974 ;Fuller 1980;Joshi etal.…”

Section: Discussionmentioning

confidence: 99%

Head-twitch response induced by ergometrine in mice: Behavioural evidence for direct stimulation of central 5-hydroxytryptamine receptors by ergometrine

Bapat

Nandal

et al. 1986

Psychopharmacology

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Ergometrine (2.5 80 mg/kg IP) induced head twitches in mice. Pretreatment with cyproheptadine (1.5 and 3 mg/kg), methysergide (5 and 10 mg/kg) and (-)-propranolol (2.5 and 5 mg/kg) significantly decreased the number of head twitches induced by ergometrine. Pretreatment with p-chlorophenylalanine (100 mg/kg/day x 4 days) and clomipramine (5 and 10mg/kg) significantly decreased the number of head twitches induced by fenfluramine (10 rag/ kg) and p-chloramphetamine (5 mg/kg) but had no significant effect on the number of head twitches induced by ergometrine. The results indicate that ergometrine induces head twitches in mice by directly stimulating central 5-hydroxytryptamine receptors.

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The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction

Cited by 36 publications

References 37 publications

EVIDENCE CONCERNING THE INVOLVEMENT OF 5‐HYDROXYTRYPTAMINE IN THE LOCOMOTOR ACTIVITY PRODUCED BY AMPHETAMINE OR TRANYLCYPROMINE PLUS l‐DOPA

EVIDENCE CONCERNING THE INVOLVEMENT OF 5‐HYDROXYTRYPTAMINE IN THE LOCOMOTOR ACTIVITY PRODUCED BY AMPHETAMINE OR TRANYLCYPROMINE PLUS l‐DOPA

A comparison of the effect of paroxetine and amitriptyline on the tyramine pressor response test.

Head-twitch response induced by ergometrine in mice: Behavioural evidence for direct stimulation of central 5-hydroxytryptamine receptors by ergometrine

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