“…Previously, studies have reported that a wide variety of eicosanoids (PGE 2 , PGD 2 , PGF 2α , TXB 2 , LTB 4 , HETEs, and LTC 4 ) is increased in the bronchoalveolar lavage fluid following ozone exposure. − Reports also have been published on the production of eicosanoids (TXB 2 , PGE 2 , cysteinyl leukotrienes, and LTB 4 ) upon the exposure of airway and tracheal epithelial cells to ozone. , Other studies have shown that ozone exposure increases eicosanoid production upon activation of the eicosanoid pathway by calcium ionophore in AM and airway segments. , More relevant to the work reported herein, the effects of ozonized lipid products on activation of the eicosanoid pathway have been examined to some extent. Arachidonic acid release by BEAS-2B cells and PGE 2 production in primary human bronchial epithelial cells were observed in the presence of the ozonized lipid product, 16:0/9al-PC. , Additionally, the ozonolysis products of membrane fatty acids, unsaturated C3-, C6-, and C9-aldehydes released from phospholipids upon ozone exposure, induced the release of AA and the subsequent formation of PGE 2 , PGF 2α , and 15-HETE in human airway epithelial cells .…”