The effect of oxytocin on basal and pethidine‐induced delayed gastric emptying.

Petring, O. U.

doi:10.1111/j.1365-2125.1989.tb05434.x

Cited by 37 publications

(42 citation statements)

References 12 publications

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“…The presence of oxytocin in the myenteric plexus suggests an effect of oxytocin in enteric neurotransmission and could explain the effect of oxytocin on motility earlier observed, where intravenous infusion of oxytocin led to increased colonic peristalsis, and to accelerated gastric emptying of a meal in healthy women [3,4], whereas the oxytocin receptor antagonist delayed the gastric emptying [5]. Activated terminals of enteric motorneurons and smooth muscle cells form functional units that release transmitters and mediate and transduce neural inputs into mechanical responses [20].…”

Section: Discussionmentioning

confidence: 93%

“…Oxytocin is secreted into the blood in response to endogenous (after a fatty meal), and exogenous cholecystokinin (CCK) in women [1,2]. Intravenous infusion of oxytocin leads to increased colonic peristalsis, and to accelerated gastric emptying of a meal in healthy subjects [3,4], whereas an oxytocin receptor antagonist delays the gastric emptying [5]. In contrast, gastric motility is inhibited in dogs and rats [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Oxytocin is expressed throughout the human gastrointestinal tract

Ohlsson

Truedsson

Djerf

et al. 2006

Regulatory Peptides

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Oxytocin is expressed throughout the human gastrointestinal tract

Ohlsson

Truedsson

Djerf

et al. 2006

Regulatory Peptides

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“…Previous data have suggested that the effects of oxytocin on gastrointestinal motility are speciesdependent. For example, oxytocin accelerates (Hashmonai et al 1979;Petring 1989), and oxytocin receptor antagonists delay (Ohlsson et al 2006a) gastric emptying in humans, but oxytocin delays gastric emptying in rats (Wu et al 2002(Wu et al , 2003. The effects of oxytocin on the human stomach appear to be direct; however, the gastric effects of oxytocin in rats are blocked by cholecystokinin antagonists and thus are probably mediated indirectly by cholecystokinin.…”

Section: Introductionmentioning

confidence: 80%

Oxytocin is expressed by both intrinsic sensory and secretomotor neurons in the enteric nervous system of guinea pig

Gao

et al. 2011

Cell Tissue Res

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Single- and double-immunostaining techniques were used systematically to study the distribution pattern and neurochemical density of oxytocin-immunoreactive (-ir) neurons in the digestive tract of the guinea pig. Oxytocin immunoreactivity was distributed widely in the guinea pig gastrointestinal tract; 3%, 13%, 17%, 15%, and 10% of ganglion neurons were immunoreactive for oxytocin in the myenteric plexuses of the gastric corpus, jejunum, ileum, proximal colon, and distal colon, respectively, and 36%, 40%, 52%, and 56% of ganglion neurons were immunoreactive for oxytocin in the submucosal plexuses of the jejunum, ileum, proximal colon, and distal colon, respectively. In the myenteric plexus, oxytocin was expressed exclusively in the intrinsic enteric afferent neurons, as identified by calbindin 28 K. In the submucosal plexuses, oxytocin was expressed in non-cholinergic secretomotor neurons, as identified by vasoactive intestinal polypeptide. Oxytocin-ir nerve fibers in the inner circular muscle layer possibly arose from the myenteric oxytocin-ir neurons, and oxytocin-ir nerve fibers in the mucosa possibly arose from both the myenteric and submucosal oxytocin-ir neurons. Thus, oxytocin in the digestive tract might be involved in gastrointestinal tract motility mainly via the regulation of the inner circular muscle and the balance of the absorption and secretion of water and electrolytes.

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“…Both OT and OT receptor (OTR) were expressed throughout the human gastrointestinal (GI) tract [6,10]. In rats, exogenous OT accelerated gastric and colonic motility in human, rabbits, and rats [3,9,12,13], inhibited the gastric emptying and intestinal transit in rats [20,21], and excited the phasic contraction of gallbladder in rabbits [4]. Most of these effects were abolished by atosiban, a specific OTR antagonist [3,4,21].…”

Section: Introductionmentioning

confidence: 99%

CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats

Feng

Che

et al. 2010

Pflugers Arch - Eur J Physiol

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The aim of the present study was to investigate the effect of oxytocin (OT) on duodenum motility in rats and the possibility that cholecystokinin (CCK) was involved in this process. The isometric contraction of longitudinal muscle strips of duodenum was monitored by polygraph. ELISA was used to measure the concentration of CCK and OT in duodenum. CCK mRNA was assayed by RT-PCR. Oxytocin receptor (OTR) and CCK in duodenum were located by immunohistochemistry and immunofluorescence staining. OT (10⁻⁵ and 10⁻⁶ M) inhibited the spontaneous contraction of the muscle strips. On the contrary, atosiban (OT receptor antagonist), lorglumide (CCK₁ receptor antagonist), and tetrodotoxin (TTX, blocker of voltage-dependent Na(+) channel on nerve fiber) excited the contraction. The inhibitory effect of OT on duodenal motility was reversed by pretreatment of atosiban, lorglumide, or TTX. Exogenous OT did not influence the expression of OT mRNA in duodenum but increased the concentration of CCK in the culture medium of the cells isolated from longitudinal muscle myenteric plexus. The OTR and CCK were co-expressed in the neurons of the myenteric plexus in duodenum. We concluded that OT inhibited the contraction of the LD spontaneous contraction of rats in vitro. This effect was mediated by the CCK released from the neurons of the myenteric plexus in duodenum.

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The effect of oxytocin on basal and pethidine‐induced delayed gastric emptying.

Cited by 37 publications

References 12 publications

Oxytocin is expressed throughout the human gastrointestinal tract

Oxytocin is expressed throughout the human gastrointestinal tract

Oxytocin is expressed by both intrinsic sensory and secretomotor neurons in the enteric nervous system of guinea pig

CCK mediated the inhibitory effect of oxytocin on the contraction of longitudinal muscle strips of duodenum in male rats

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