The Effect of Oxytocin Infusion on Adenohypophysial and Adrenal Cortical Responses to Insulin‐induced Hypoglycaemia

Nussey, S. S.; Page, Sean; Ang, V. T. Y.; Jenkins, Janis H.; White, Anne

doi:10.1111/j.1365-2265.1988.tb01223.x

Cited by 11 publications

(13 citation statements)

References 24 publications

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“…In rats, hypophyseal portal concentrations of AVP but not of CRH and OXT increase in response to hypoglycaemia (Plotsky et al, 1985b). Thus, our data showing that OXT had no effect of the ACTH response to combined AVP and CRH, together with our previous report of the lack of effect of OXT on the ACTH response to insulin-induced hypoglycaemia (Nussey et al, 1988), is consistent with AVP being the major stimulus to ACTH release in response to insulin-induced hypoglycaemia in man. Thus, our data showing that OXT had no effect of the ACTH response to combined AVP and CRH, together with our previous report of the lack of effect of OXT on the ACTH response to insulin-induced hypoglycaemia (Nussey et al, 1988), is consistent with AVP being the major stimulus to ACTH release in response to insulin-induced hypoglycaemia in man.…”

Section: Discussionsupporting

confidence: 90%

“…The present study showing no effect of OXT on the GH response to a sub-maximal dose of GHRH, together with our previous report showing no effect of OXT on the GH response to insulin-induced hypoglycaemia (Nussey et al, 1988), suggests it is unlikely that OXT modulates the release of GH in man. However, we cannot exclude an interaction of OXT on AVP-mediated GH release as reported by Chiodera et al (1984a).…”

Section: Discussionsupporting

confidence: 59%

“…Studies using rats in vitro (Antoni et al, 1983) and in vivo (Gibbs 1984b(Gibbs , 1986) suggest a stimulatory effect of OXT on ACTH secretion. However, others have been unable to confirm these observations (Lewis & Sherman, 1985;Nussey et al, 1988). However, others have been unable to confirm these observations (Lewis & Sherman, 1985;Nussey et al, 1988).…”

Section: Discussionmentioning

confidence: 98%

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The Effect of Oxytocin Infusion on Adenohypophyseal Function in Man

Page

Ang

Jackson

et al. 1990

Clinical Endocrinology

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The responses of the adenohypophyseal hormones adrenocorticotrophin (ACTH), growth hormone (GH), thyroid stimulating hormone (TSH), prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) to sub-maximal doses of hypothalamic releasing factors were studied in six lean male volunteers (age 23-35 years) with and without infusions of oxytocin (OXT). OXT infusion (mean plasma concentration 133.6 +/- 2.6 pmol/l) completely inhibited the plasma ACTH responses to corticotrophin releasing hormone (CRH) (saline, peak increment ACTH 1.61 +/- 0.75 pmol/l; OXT, peak increment ACTH - 0.04 +/- 0.28 pmol/l; P less than 0.05). OXT infusion had no significant effect on the GH response to growth hormone releasing hormone (GHRH), the TSH and prolactin responses to thyrotrophin releasing hormone (thyroliberin, TRH) or the LH and FSH responses to gonadotrophin releasing hormone (luteoliberin, GnRH). The data support a role for OXT in the modulation of ACTH secretion in man.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 98%

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The Effect of Oxytocin Infusion on Adenohypophyseal Function in Man

Page

Ang

Jackson

et al. 1990

Clinical Endocrinology

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“…Oxytocin has also been found to increase CRH-mediated ACTH secretion in oioo (Gibbs et al, 1984), and passive immunoneutralization of oxytocin decreased the ACTH response to stress (Gibbs, 1985). In complete contrast to these observations in the rat, Legros et al (1982) reported that the infusion of oxytocin in human males was followed by inhibition of the ACTH response to insulin-induced hypoglycaemia, although, using this same stimulus for ACTH release, these results could not be confirmed by other workers (Lewis & Sherman, 1985;Nussey et al, 1988b). However, oxytocin has been reported to inhibit the ACTH response to metyrapone (Chiodera & Coiro, 1987), and to exercise (Coiro et al, 1988) in normal men.…”

Section: Acth Secretionmentioning

confidence: 88%

The role of oxytocin: present concepts

Jenkins

Nussey

1991

Clinical Endocrinology

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indeed involved in human parturition. The onset of labour is associated with only a slight to moderate increase in the levels of oxytocin in the blood but as labour progresses there is a further increase, probably related to distension of the genital tract (Ferguson reflex). Even the reports that patients with diabetes insipidus and no detectable circulating oxytocin can proceed to normal labour can be reconciled with the Oxytocin has the distinction of being the first peptide hormone to be sequenced and synthesized (Du Vigneaud et al., 1954). The synthesis of arginine vasopressin was achieved closely afterwards, culminating in Du Vigneaud being awarded the Nobel prize for chemistry. These nonapeptides of the neurohypophysis differ only in two amino acids but while vasopressin has been intensively studied, and has now been shown to have a multiplicity of actions, oxytocin has received much less attention. Its actions have traditionally been confined to those affecting the uterus and breast, and the major purpose of this review is to consider the evidence for other functions, emphasizing wherever possible results from human studies. Classical functions of oxytocinIn the course of its classical functions oxytocin is synthesized in the magnocellular neurones of hypothalamic nuclei as a precursor molecule and is transported axonally in association with its neurophysin to the neurohypophysis from whence it is released into the circulation. It is clear from immunohistochemical studies that the oxytocin-secreting neurones are different from those which produce vasopressin (Dierickx & Vandesande, 1977) and the regulatory mechanisms are also quite separate. Actions on the uterusThe stimulatory effect of posterior pituitary extracts on the contractions of the uterus was first described by Dale (1906) and the therapeutic use of such extracts in labour was demonstrated soon afterwards (Blair Bell, 1909). However, in spite of these reports, which appeared over 80 years ago, there has been some controversy as to the physiological role of oxytocin in human parturition. Fuchs and Fuchs (1984) have reviewed the topic in some detail and from their own work, and that of many others, they conclude that oxytocin is

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“…Oxytocin reduced ACTH which was stimulated by insulin-induced hypoglycaemia, by vasopressin (96) or by CRH (97). Investigations in which ACTH rises were not sensitive to oxytocin have also been reported (98,99).…”

Section: Acthmentioning

confidence: 95%

Oxytocin in the human--regulation of derivations and destinations

Evans

1997

European Journal of Endocrinology

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The Effect of Oxytocin Infusion on Adenohypophysial and Adrenal Cortical Responses to Insulin‐induced Hypoglycaemia

Cited by 11 publications

References 24 publications

The Effect of Oxytocin Infusion on Adenohypophyseal Function in Man

The Effect of Oxytocin Infusion on Adenohypophyseal Function in Man

The role of oxytocin: present concepts

Oxytocin in the human--regulation of derivations and destinations

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