The Effect of Oxytetracycline on the Severity of Airsacculitis in Chickens Infected with Mycoplasma gallisepticum

Glisson,; Ih, Cheng; Brown, John P.; Rg, Stewart

doi:10.2307/1591155

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…Mycoplasma gallisepticum is a simple prokaryote that functions as the major pathogen of chronic respiratory disease (CRD; Levisohn & Kleven, 2000) in fowl. The disease is prevalent in commercial poultry farms with weak health control measures, CRD retards growth, decreases the laying rate, and lowers the feed conversion ratio (Glisson et al, 1989;Machado et al, 2012). The disease is difficult to eradicate because of its vertical transmission through the eggs (Lin & Kleven, 1982).…”

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confidence: 99%

Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics

Xiao

Zhao

Yang

et al. 2013

Vet Pharm & Therapeutics

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A Mycoplasma gallisepticum-Escherichia coli mixed infection model was developed in broiler chickens, which was applied to pharmacokinetics of valnemulin in the present experiment. The velogenic M. gallisepticum standard strain S6 was rejuvenated to establish the animal model, and the wild E. coli strain O78 was injected as supplementary inoculum to induce chronic respiratory disease in chickens. The disease model was evaluated based on its clinical signs, histopathological examination, bacteriological assay, and serum plate agglutination test. The pharmacokinetics of valnemulin in infected chickens was determined by intramuscular (i.m.) injection and oral administration (per os, p.o.) of a single dose of 10 mg/kg body weight (BW). Plasma samples were analyzed by liquid chromatography-tandem mass spectrometry. The plasma concentration-time curve of valnemulin was analyzed using the noncompartmental method. After the i.m. administration, the mean values of Cmax , Tmax , AUClast , MRT, CLβ /F, Vz /F, and t1⁄2β , were 27.94 μg/mL, 1.57 h, 171.63 μg·h/mL, 4.51 h, 0.06 L/h/kg, 0.56 L/kg, and 6.50 h, respectively. By contrast, the corresponding values after p.o. administration were 5.93 μg/mL, 7.14 h, 47.60 μg·h/mL, 9.80 h, 0.22 L/h/kg, 3.35 L/kg, and 10.60 h. The disposition of valnemulin was retarded in infected chickens after both modes of extravascular administration as compared to the healthy controls. More attention should be given to monitoring the therapeutic efficacy and adverse effects of mixed infection because of higher required plasma drug concentration and enlarged AUC with valnemulin treatment.

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confidence: 99%

Mycoplasma gallisepticum and Escherichia coli mixed infection model in broiler chickens for studying valnemulin pharmacokinetics

Xiao

Zhao

Yang

et al. 2013

Vet Pharm & Therapeutics

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“…Tiamulin was more effective than the reference antibiotics in preventing and eradicating airsacculitis caused by Mycoplasma gallisepticum. Glisson et al (1989) investigated the effect of oxytetracyline (OTC) on the severity of airsacculitis in chickens infected with Mycoplasma gallisepticum. There was a similarity in the efficacy of tiamulin studied by Youxiang et al (2003), who worked out the efficacy of tiamulin and chlortetracycline in feed in the control of CRD in broilers.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Tylosin and Tiamulin against Mycoplasmosis in poultry

Habib

Mahdy

Islam

et al. 2017

Res. Agric. Livest. Fish.

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Tylosin Tiamulin Mycoplasmosis Layer CRD Chronic respiratory disease (CRD) is one of the most important veterinary diseases inBangladesh and all over the world. Mortality, reducing of weight gain and increasing of feed conversion ratio (FCR) are caused by CRD. Several drugs are used for prevention and control of Mycoplasmosis. It is caused by Mycoplasma gallisepticum (MG). Tylosin and Tiamulin are effective on M. gallisepticum. By considering generating resistance against antibiotics that is effective on MG, studying the effect of these drugs in the treatment and prevention of Mycoplasmosis in birds were the purpose of this research. In this study, 36 layer birds (MG positive) of 25 weeks aged divided in three similar groups (A, B and C) contain 12 birds in each group. In group A; Tylosin was administered after mixing with 2.5 gm in 1 L drinking water, for Group B; Tiamulin was administered after mixing with feed @ 0.45gm/kg feed and Group C; Control (No antibiotic was given, only common feeding). The Serum Plate Agglutination (SPA) test was conducted; in positive cases granules were formed slowly which could be seen during rocking. In the negative case, no such granules were formed. Overall 6 and 9 serums shown negative SPA test in Group A and Group B, respectively. Therefore, the efficacy of Tylosin was 50.00% and the Tiamulin was 75.00% which resemble statistically significant (P<0.05). In control group, 5 birds were died during experiment. It can be concluded that usage of these antibiotics especially Tiamulin can be essential in the treatment and prevention of Mycoplasmosis in birds.

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“…In the treatment of avian mycoplasmosis, antibiotics are frequently used in naturally infected birds (Hamdy et al, 1982;Glisson et al, 1989;Charleston et al, 1998;Hannan, 2000) but the development of resistance against various antibiotics has been reported by various scientists across the globe Gautier-Bouchardon et al, 2002;Pakpinyo and Sasipreeyajan, 2007). Tripathy et al (1972) treated the infraorbital swelling of peafowl with vitamin A and terramycin (intramuscular; I/M) and terramycin (0.5ml) infused into the swelling after removal of exudate.…”

Section: Treatment Of Mycoplasmosismentioning

confidence: 99%