The effect of oxygen plasma pretreatment and incubation in modified simulated body fluids on the formation of bone-like apatite on poly(lactide-co-glycolide) (70/30)

Qu, Xue; Cui, Wenjin; Yang, Fei; Min, Changchun; Shen, Hong; Bei, Jianzhong; Wang, Shenguo

doi:10.1016/j.biomaterials.2006.08.024

Cited by 81 publications

(59 citation statements)

References 33 publications

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“…After oxygen plasma treatment, as shown in Figure 2 some kind of abrasion defects can be seen on the surface of the membranes, which does not appear for the membranes without plasma treatment. Surface abrasion that was already found in plasma treated PLLA by Wang et al [18] can allow HA particles to appear at the pores walls.…”

Section: (Left) and (Right)]mentioning

confidence: 99%

“…This method is based on phase separation, like liquid-liquid demixing, whereby the solvent and the polymer crystallises in the polymer-poor phase and the polymer-rich phase, respectively [17]; thus leaving a porous morphology when the crystallised solvent is removed with the aid of a good solvent. These membranes were then modified by plasma treatment in order to enhance their bioactivity [18]. As polymer containing carboxylic acids show high plasma susceptibility, the plasma treatment was applied as to help initiate the nucleation of a layer of HA.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the content of hydroxyapatite nanoparticles on the properties and bioactivity of poly(l-lactide) – Hybrid membranes

Deplaine

Ribelles

Ferrer

2010

Composites Science and Technology

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Section: (Left) and (Right)]mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of the content of hydroxyapatite nanoparticles on the properties and bioactivity of poly(l-lactide) – Hybrid membranes

Deplaine

Ribelles

Ferrer

2010

Composites Science and Technology

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“…In the last decade, diverse strategies in surface modification have been applied on implantable biomaterials such as hydroxyapatite (HA) [1], low-density polyethylene (LDPE) [2] and poly(L-lactic-co-glycolic acid) (PLGA) [3] to improve their intended functions in the body. One of the main purposes for surface modification is to enhance or inhibit protein adsorption on the surface of biomaterials.…”

Section: Introductionmentioning

confidence: 99%

Modulating protein adsorption onto hydroxyapatite particles using different amino acid treatments

Lee

Loo

Van

et al. 2011

J. R. Soc. Interface.

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Hydroxyapatite (HA) is a material of choice for bone grafts owing to its chemical and structural similarities to the mineral phase of hard tissues. The combination of osteogenic proteins with HA materials that carry and deliver the proteins to the bone-defective areas will accelerate bone regeneration. The study investigated the treatment of HA particles with different amino acids such as serine (Ser), asparagine (Asn), aspartic acid (Asp) and arginine (Arg) to enhance the adsorption ability of HA carrier for delivering therapeutic proteins to the body. The crystallinity of HA reduced when amino acids were added during HA preparation. Depending on the types of amino acid, the specific surface area of the amino acid-functionalized HA particles varied from 105 to 149 m 2 g -1. Bovine serum albumin (BSA) and lysozyme were used as model proteins for adsorption study. The protein adsorption onto the surface of amino acid-functionalized HA depended on the polarities of HA particles, whereby, compared with lysozyme, BSA demonstrated higher affinity towards positively charged Arg-HA. Alternatively, the binding affinity of lysozyme onto the negatively charged Asp-HA was higher when compared with BSA. The BSA and lysozyme adsorptions onto the amino acid-functionalized HA fitted better into the Freundlich than Langmuir model. The amino acid-functionalized HA particles that had higher protein adsorption demonstrated a lower protein-release rate.

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“…This may be explained by the differences in bone-like apatite used in various studies, as different preparation methods could cause variations in the physical properties of apatite, such as crystallinity, crystal size, surface topography, elemental composition/ratio and the dissolution rate of apatite. Each of these properties could substantially influence the attachment, proliferation and differentiation of osteoblasts in vitro [12]. Kim et al [13] also reported that the ALP activity of osteoblast-like cells on the hydroxyapatite coating of zirconia porous scaffolds was increased in comparison with those on pure β-TCP, with higher dissolution rates.…”

Section: Comparative Study Of the Cell Viability On Plga And Plga/β-tmentioning

confidence: 99%

Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts

et al. 2010

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Osteoblasts were cultured on porous scaffolds of poly(L-lactide-co-glycolide) (PLGA) and PLGA/β-tricalcium phosphate (β-TCP) to evaluate their cytocompatibility. The proliferation of the cells on both scaffolds was examined before and after in vitro degradation for 4, 8 and 12 weeks under static (shaking water bath) and dynamic (cyclic loading) conditions. Results indicate that porous PLGA and PLGA/β-TCP scaffolds have good biocompatibility and can be used as effective templates for guiding the growth of osteoblasts. The degradation of the scaffolds affects the proliferation of osteoblasts and the cell viability decreased with the degradation time.

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The effect of oxygen plasma pretreatment and incubation in modified simulated body fluids on the formation of bone-like apatite on poly(lactide-co-glycolide) (70/30)

Cited by 81 publications

References 33 publications

Effect of the content of hydroxyapatite nanoparticles on the properties and bioactivity of poly(l-lactide) – Hybrid membranes

Effect of the content of hydroxyapatite nanoparticles on the properties and bioactivity of poly(l-lactide) – Hybrid membranes

Modulating protein adsorption onto hydroxyapatite particles using different amino acid treatments

Effect of degradation of PLGA and PLGA/β-TCP scaffolds on the growth of osteoblasts

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