The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development

Regan, Sheena L.P.; Knight, P. G.; Yovich, John L.; Stanger, James; Leung, Yee; Arfuso, Frank; Almahbobi, Ghanim; Dharmarajan, Arun

doi:10.1016/j.mce.2017.11.002

Cited by 37 publications

(30 citation statements)

References 68 publications

(73 reference statements)

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“…However, a recent flow cytometry study with selective gating of pure mural GCs (identified by the expression of FSH receptor) observed lower apoptosis rate (measured by 7‐amino‐actinomycin incorporation by apoptotic cells) in follicles from women over 35 years compared to younger ones. The apoptosis rate was also lower in women over 40 years with diminished ovarian reserve compared to a group of the same age with normal ovarian reserve (Regan et al, ). On possible interpretation of these conflicting observations is that cumulus cell apoptosis would increase with advanced age (Lee et al, ) whilst mural CGs apoptosis paradoxically decreases due to a slower turnover of this cell population (Regan et al, ).…”

Section: Resultsmentioning

confidence: 99%

Clinical correlation of apoptosis in human granulosa cells—A review

Almeida

Ferreira

Silveira

et al. 2018

Cell Biology International

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The quality of oocytes depends on interactions with surrounding granulosa cells. Granulosa cells are essential in normal follicular maturation process since they produce steroidal hormones and growth factors, and they play a crucial role in follicular atresia. The success in reproductive biology and medicine depends on reliable assessment of oocyte and embryo viability which presently mainly bases on oocyte and embryo morphology. Recent investigations have tried to establish an evaluation system for oocyte quality and to predict outcome of in vitro fertilization (IVF) based on the incidence of granulosa cells and cumulus cells apoptosis. Apoptosis of granulosa cells seems to have a negative effect on conception and pregnancy rates in IFV programs. Thus, in this review we present a brief outline of clinical correlation of apoptosis in human granulosa cells and cumulus cells, and its influence upon oocyte quality and IFV outcome. Taken together, understanding the influence of granulosa cell apoptosis on oocyte quality and maturity as well as on embryo health may ultimately allow scientists and clinicians to harness better protocols of ovarian stimulation for infertility treatments.

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Section: Resultsmentioning

confidence: 99%

Clinical correlation of apoptosis in human granulosa cells—A review

Almeida

Ferreira

Silveira

et al. 2018

Cell Biology International

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“…In addition, granulosa cell apoptosis increases dramatically around the time of dominant follicle selection when the ratio of androgen is greater than estrogen ( 49 , 57 – 59 ). The start of follicle selection coincides with the down-regulation of granulosa cell BMPR1B and FSHR expression ( 3 , 4 , 9 ).…”

Section: Regulation Of Bmpr1b and Fshr And Their Influence On Apoptosmentioning

confidence: 99%

“…The follicles with granulosa cells expressing LHRs are able to continue to produce estrogens, and are recruited into the dominant cohort. FSHR is protective against apoptosis; therefore, as the FSHR level falls, apoptosis increases ( 4 ).…”

Section: Regulation Of Bmpr1b and Fshr And Their Influence On Apoptosmentioning

confidence: 99%

“…The recent study of Regan et al ( 4 , 5 ) examined the relationship between ovarian reserve, granulosa cell receptor density and apoptosis during healthy human follicle development. The effect of the age of women undergoing the IVF protocol on granulosa cell apoptosis rate related to cell surface gonadotropin receptor and BMPRIB receptor expression.…”

Section: The Relationship Between Apoptosis and Oocyte Qualitymentioning

confidence: 99%

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Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View

et al. 2018

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Recent studies challenge the previous view that apoptosis within the granulosa cells of the maturing ovarian follicle is a reflection of aging and consequently a marker for poor quality of the contained oocyte. On the contrary, apoptosis within the granulosa cells is an integral part of normal development and has limited predictive capability regarding oocyte quality or the ensuing pregnancy rate in in vitro fertilization programs. This review article covers our revised understanding of the process of apoptosis within the ovarian follicle, its three phenotypes, the major signaling pathways underlying apoptosis as well as the associated mitochondrial pathways.

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“…Such topographicanatomical peculiarities can be considered standard for the fetuses of the given age group. Though they can be indicative of developmental retardation at the late stages of the perinatal development, which is not mentioned in the works of certain researchers [9,14,16,19,23,25].…”

Section: Discussionmentioning

confidence: 98%

Ovarian characteristics in the fetal period: topographic and morphometric parallels

Проняєв

Bulyk

2019

Biomed. and Biosoc. Anthrop.

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Defects of the urinary system take the 3rd place by their occurrence including 6% of developmental defects of the female reproductive organs. Therefore modern studies in the field of perinatal anatomy are of a special importance. Objective of the study was to determine age peculiarities in the structure and topography of the fetal ovaries as well as similar and different tendencies in changes of the ovarian morphological parameters of the two groups of fetuses, remote in time. The study was conducted in the two groups of human fetuses, 4-10 months of development, 161.0-500.0 mm of the parietal-calcaneal length. The first group consisting of 35 specimens divided into 7 subgroups according to the month of development (4, 5, 6, 7, 8, 9 and 10), was formed with fetuses died during 2017-2019 years. The second group included specimens of fetuses collected during 1970-1990. The obtained results were statistically processed in the licensed statistical package “Statistica 6.0”. The character of distribution for every obtained variation lines, mean values for every sign, standard quadratic deviation, percentile scope of the parameters were evaluated. Reliability of differences in the indices between independent quantitative values was determined by means of Mann-Whitney U-criterion. The conducted study determined that the ascending position of the ovaries in the early fetuses can be considered normal for the given age group, though the topography is indicative of developmental retardation at the late stages of perinatal development. The length of the ovary in both groups increases gradually from the 4th to the 10th month with a certain delay during the 6th month. It might be associated with intensified growth of its parenchyma, and intensive increase of its width and length respectively. The majority of the ovarian parameters of 9-10 month fetuses do not differ reliably, which is indicative of a complete development of the ovarian definite structure at the 9th month of the intrauterine development. Comparison of the parameters of the two groups of fetal specimens, remote in time, is indicative of the fact that in the majority of the parameters they do not differ. Although in modern studies the length of the right ovary in 8-month fetuses, and the length of the left ovary in 7-month fetuses is shorter than that of the archival specimens. Similarly the width of the left ovary in 4-month fetuses appears to be reliably shorter than that of the archival specimens. The thickness of the right ovary of 7 and 10-month modern fetuses is reliably less than that of the appropriate groups of the archival specimens. The thickness of the left ovary of modern fetuses is reliably less than that of the archival specimens during the 10th month. Therefore, a reliable difference was found only in 2 pairs of the parameters included in 42 pairs of the examined morphometric parameters of both groups. It is indicative of inconsiderable changes of these parameters during the period of 27-49 years.

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The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development

Cited by 37 publications

References 68 publications

Clinical correlation of apoptosis in human granulosa cells—A review

Clinical correlation of apoptosis in human granulosa cells—A review

Granulosa Cell Apoptosis in the Ovarian Follicle—A Changing View

Ovarian characteristics in the fetal period: topographic and morphometric parallels

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