The Effect of Ovarian Extracts Upon the Spontaneous Contractions of the Fallopian Tube of the Domestic Pig With Reference to the Oestrous Cycle

Seckinger, Daniel

doi:10.1152/ajplegacy.1924.70.3.538

Cited by 17 publications

(16 citation statements)

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“…(1) the powerful inner layer of circular muscle in the oviduct isthmus, richly endowed with a network of nerves and adrenergic terminals (Brundin, 1969), (2) the opposing influences of oestradiol and progesterone, respectively, in potentiating a-and b-adrenergic receptors in the myosalpinx (Hunter, 1977), (3) the much-enhanced contractions of the myosalpinx close to the time of ovulation (Seckinger, 1923;Wislocki and Guttmacher, 1924;Battalia and Yanagimachi, 1979), (4) the fact that sperm cells have specific catecholamine receptors and respond to various preparations of catecholamines Cornett et al, 1979;Fraser and Adeoya-Osiguwa, 2006), (5) the presence of catecholamines in oviduct luminal fluid (Khatchandourian et al, 1987;Way et al, 2001;Kotwica et al, 2003).…”

Section: Catecholamine and Ca 2þ Ionmentioning

confidence: 99%

“…Specific epithelial binding would counteract the influence of powerful adovarian waves of myosalpingeal contraction provoked by multiple mating and prevent bulk displacement of viable spermatozoa towards the site of fertilisation. Such contractile activity is especially prominent in oestrous animals (see Corner, 1923;Seckinger, 1923;Wislocki and Guttmacher, 1924) and is enhanced by episodes of mating or simply in the close vicinity of mature males. A diminishing gradient in sperm numbers along the isthmus would reduce the risk of polyspermic fertilisation and therefore have strong selective advantages.…”

Section: An Evolutionary Perspectivementioning

confidence: 99%

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Sperm release from oviduct epithelial binding is controlled hormonally by peri‐ovulatory graafian follicles

Hunter

2007

Molecular Reproduction Devel

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To avoid inappropriate conclusions being drawn from the extensive use of in vitro preparations of sperm-oviduct epithelial binding, it is recalled that events in the genital tract of mammals are regulated by the gonads, primarily by their changing secretion of steroid hormones. Key observations from in vivo models are used to emphasise the dynamic interactions between viable sperm cells and the caudal (distal) portion of the oviduct isthmus, the site of the functional sperm reservoir. These include (1) preovulatory arrest and epithelial binding of intact sperm cells and thereby suppression of completion of capacitation, (2) peri-ovulatory activation and release from binding of discrete sub-populations of competent spermatozoa, and (3) post-ovulatory liberation of large numbers of spermatozoa. These observations underline the influence of endocrine regulation of sperm binding and release by peri-ovulatory Graafian follicles, a point brought out by the enhanced sperm release prompted by diverse treatments with solutions of progesterone. In the light of this evidence, the suitability of in vitro preparations for clarifying physiological events should be questioned, especially if myosalpingeal catecholamines diffusing out of the autonomic nervous system contribute to sperm activation and/or release. None of this is to infer that sperm cells themselves are without influence on their epithelial binding reaction(s). Nor is it to suggest that in vitro models of sperm-oviduct binding are without relevance to the development of sperm evaluation technologies. However, pre-ovulatory sperm-epithelial binding and a regulated peri-ovulatory release should be seen as vital tactics in the overall strategy of achieving successful monospermic fertilisation. Mol. Reprod. Dev. 75: 167-174, 2008.

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Section: Catecholamine and Ca 2þ Ionmentioning

confidence: 99%

Section: An Evolutionary Perspectivementioning

confidence: 99%

Sperm release from oviduct epithelial binding is controlled hormonally by peri‐ovulatory graafian follicles

Hunter

2007

Molecular Reproduction Devel

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“…3). This may appear surprising, given the active myosalpingeal contraction close to the time of ovulation (58,59) and likewise the intensive beat of endosalpingeal cilia (60). Together, these two forms of activity would have been expected to promote considerable mixing of the tubal contents.…”

Section: Fallopian Tube Fluid Specializationsmentioning

confidence: 99%

Have the Fallopian tubes a vital rôle in promoting fertility?*

Hunter¹

1998

Acta Obstet Gynecol Scand

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Diverse lines of evidence suggest that the Fallopian tubes make no overwhelming contribution to human reproduction other than as a conduit for gametes and embryos. Even so, bearing in mind global success rates for in vitro fertilization (IVF) coupled with uterine transplantation of embryos (20% fruitful pregnancies), the Fallopian tubes may make a subtle contribution to reproductive performance. The experimental evidence from monkeys and man arguing against an essential rôle for the tubes -- at least in individual instances -- would include (1) the results of Estes' operation, when ovaries are autotransplanted into the uterine lumen in women with blocked or missing Fallopian tubes and pregnancy ensues; (2) asynchronous embryo transfer when newly fertilized (pronucleate) eggs transplanted to the uterus can generate a pregnancy; (3) the transcervical transfer after IVF of early cleavage stage human embryos into the uterus, with subsequent establishment of pregnancy; (4) the trans-cervical transfer of human spermatozoa and oocytes into the uterus to give pregnancy, indicating that capacitation, fertilization and the earliest stages of embryonic development can be achieved in the uterus. In endeavoring to explain contrasts between these successful procedures in primates and their failure in non-primates, perhaps the simplex uterus in primates compared with a bicornuate or bipartite uterus in laboratory and farm species has relevance: there is lack of a clear-cut distinction between the endometrium and endosalpinx in the intra-mural segment and potential mixing of uterine and tubal fluids. Indeed, the latter may explain in part a susceptibility to tubal ectopic pregnancy, coupled with proliferating endometrial fragments in the Fallopian tube.

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“…The injection of oestrin into the immature animal brings about the appearance of precocious oestrous symptoms, including opening of the vaginal orifice, and where such symptoms may be detected in the intact animal, as in the rat and mouse, this is a fairly convenient test for oestrusproducing activity. It suffers, however, from two disadvantages An entirely different method of assaying oestrous activity has been put forward by Frank and his coworkers (222), by Seckinger (555) and by Brouha and Simonnet (103), who have suggested that the effect of the oestrous hormone on the spontaneous contractions of the uterus (see p. 203) could be used as a criterion. Such a proceeding, however, has obvious disadvantages.…”

Section: Intra-venoiis Injectionmentioning

confidence: 99%

The Internal Secretions of the Ovary

Parkes¹

1931

The Journal of Nervous and Mental Disease

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The Effect of Ovarian Extracts Upon the Spontaneous Contractions of the Fallopian Tube of the Domestic Pig With Reference to the Oestrous Cycle

Cited by 17 publications

References 0 publications

Sperm release from oviduct epithelial binding is controlled hormonally by peri‐ovulatory graafian follicles

Sperm release from oviduct epithelial binding is controlled hormonally by peri‐ovulatory graafian follicles

Have the Fallopian tubes a vital rôle in promoting fertility?*

The Internal Secretions of the Ovary

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