The effect of osteocyte‐derived RANKL on bone graft remodeling: An in vivo experimental study
Balazs Feher,
Carina Kampleitner,
Patrick Heimel
et al.
Abstract:ObjectivesAutologous bone is considered the gold standard for grafting, yet it suffers from a tendency to undergo resorption over time. While the exact mechanisms of this resorption remain elusive, osteocytes have been shown to play an important role in stimulating osteoclastic activity through their expression of receptor activator of NF‐κB (RANK) ligand (RANKL). The aim of this study was to assess the function of osteocyte‐derived RANKL in bone graft remodeling.Materials and MethodsIn Tnfsf11fl/fl;Dmp1‐Cre m… Show more
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