The Effect of Orotic Acid on the Bilirubin‐absorptive Power of Plasma Albumin in Newborn Infants

Kintzel, H. W.; Braun, W.; Hinkel, G. K.; Koslowski, H. R.; Schwarze, Roland

doi:10.1111/j.1651-2227.1972.tb15970.x

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1974

1980

Publication Types

Select...

Article1

Book1

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum bilirubin levels in premature infants must be kept to a minimum if kernicterus is to be avoided. For prophylactic medication there are two alternatives-orotic acid (10,12,14,18,21,22,29), or an enzyme inductor. Over several years, phenobarbital has proved to be an efficient inductor (23,26,27,28,30,31).…”

mentioning

confidence: 99%

An Enzyme Inductor Combination for the Prevention of Hyperbilirubinemia in Premature Infants

et al. 1974

Self Cite

View full text Add to dashboard Cite

GDR). Enzyme inductor combination to prevent hyperbilirubinaemia in premature in-. fants. Acta Paediatr Scand, 63: 393, 1974.-In the management of physiologic hyperbilirubinemia in newborn infants, phenobarbital and nicethamide (diethylnicotinamide), as an enzyme inductor combination, are found to have a cumulative effect and, consequently, are clearly superior to the use of phenobarbital alone. Four different dosages were compared and the most favourable variant proved to be phenobarbital, 10 mg/kg body weight pro die from day 1 to day 3 (after birth), combined with nicethamide, 100 mg/kg per diem from day 1 to day 4. Exchange transfusion was no longer necessary in 400 premature infants who had received this type of prophylactic combination and thus the routine use of this inductor regimen can now be recommended.

show abstract