The effect of orally administered zinc sulfate (ZNSO4) on healing incised wounds

Kim, Zung Wan; Rosenthal, Stoyan P.

doi:10.1016/0022-4804(70)90087-9

Journal of Surgical Research

1970

DOI: 10.1016/0022-4804(70)90087-9

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The effect of orally administered zinc sulfate (ZNSO4) on healing incised wounds

Zung Wan Kim

Stoyan P. Rosenthal

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1973

1996

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Cited by 8 publications

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Zinc metabolism and surgical trauma

Hallböök

Hedelin

1977

British Journal of Surgery

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Several investigations have shown that zinc deficiency impairs wound healing in surgical wounds and in chronic ulcers. It is also well established that surgical trauma produces a sharp decrease in serum zinc concentration. It has not been clearly shown that this decrease is due to a rise in urinary excretion. In the present investigation the relationship between urinary zinc excretion and the fall in serum zinc postoperatively was studied in 38 patients. Older patients usually had low preoperative serum zinc concentrations. Preoperative zinc substitution is therefore suggested for such patients.

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Zinc metabolism and surgical trauma

Hallböök

Hedelin

1977

British Journal of Surgery

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Serum protein and zinc levels in patients with thoracic empyema

Özgüneş

1996

Biol Trace Elem Res

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The element Zn is the metal component or activator of many important enzymes. The tissue concentrations and activities of Zn metalloenzymes direct the rate of protein and nucleic acid syntheses, thereby influencing tissue growth and reperative processes. Most of the serum Zn is normally bound to circulating proteins. Low serum Zn concentrations might result from depletion of Zn-binding proteins. Serum protein and Zn concentrations have been reported to be depressed in patients with acute and chronic diseases. We compare the serum protein and Zn values of patients with thoracic empyema (n = 20) with those of a control group (n = 20). The values obtained in the empyema group were significantly lower than those in the control group before the study. Test group administered 220 mg zinc sulfate (ZnSO4.7H2O) over 20 d and there was a significant increase in the values for serum protein and Zn after the oral administration of the zinc sulfate.

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The effects of oral zinc supplementation in the mouse

Aughey

Grant

Furman

et al. 1977

Journal of Comparative Pathology

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The effect of orally administered zinc sulfate (ZNSO4) on healing incised wounds

Cited by 8 publications

References 2 publications

Zinc metabolism and surgical trauma

Zinc metabolism and surgical trauma

Serum protein and zinc levels in patients with thoracic empyema

The effects of oral zinc supplementation in the mouse

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