The Effect of Orally Administered Herbal Medicines in Collagen, LPS, CFA Induced Rheumatoid Like Arthritis Animal Model: A Systematic Review of Animal Study Articles Published in Korea after 2008

Abstract

Objectives This study was designed to review animal studies about the efficacy of herbal medicine for Rheumatoid arthritis animal model which was published in Korea after 2008. We also systematically investigated the reporting quality of the animal studies. Methods We systematically searched original articles in 8 databases since 2008. And manual searching was conducted through 10 Korean medicine journals from 2008. Studies were included if they used animal experimental model(s) with orally administered herbal medicine. Data were extracted regarding animal model, rheumatoid arthritis indicator and detail of intervention. Reporting quality of each study was also assessed by the STARA and ARRIVE guidelines. Results Nine hundred two articles were screened. Finally, 35 articles were included. 35 studies all showed that the herbal medicine used in the studies has significant effect on alleviating the macroscopic indicators, hematological indicators, histological indicators, genetic indicators, osteological indicator of Rheumatoid Arthritis and others. Species of animals was reported in 100% while ventilation and noise were reported in 0% in STRASA guidelines. Ethical statement was reported in 42.9%, experimental animals and sample size were reported in 24%, 29% and there was no study reporting funding. Conclusions These results suggest that herbal medicine might be effective treatment for Rheumatoid Arthritis. It should be improved by clinical studies. And there is a need for studying about efficacy and safety of each specific herbal medicine. And we should improve the Reporting quality of the animal studies published in Korea.

Healing Effect ofCordyceps MilitarisExtract Complex on Collagen II-Induced Arthritis Rats

“…Total amount 37 한의학에서는 류마티스 관절염을 歷節風, 痺證 23) 등 으로 보아 그 원인에 따라 行痺(風), 痛痺(寒), 着痺(濕), 熱痺, 瘀血痺 등으로 구분하여 치료하며 24) 체계적 문헌 고찰을 통해 한약제제 투여가 류마티스 관절염 치료에 효과적임을 밝힌 바 있다 25) .…”

Reporting Qualitative Research of Systematic Review in the Journal of Korean Medicine Rehabilitation According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 Guidelines

“…1). 이 중 23편 은 체계적 문헌고찰 및 메타분석, 2편 44,45) 은 메타분석을 부분적으로 실시한 체 계적 문헌고찰, 3편 [46][47][48] 은 정성적 합성(qualitative syn-thesis)을 실시한 체계적 문헌고찰, 10편 [49][50][51][52][53][54][55][56][57][58] 은 체계적 문 헌고찰, 1편 59) 은 신속 체계적 문헌고찰이었다. 총 41개 항목 중 24개 항목을 보고한 문헌이 1편 30) , 22개 항목을 보고한 문헌이 2편 37,39) , 21개 항목을 보고한 문헌이 5편, 20개 항목을 보고한 문헌이 8편, 19개 항목 을 보고한 문헌이 3편 28,46,47) , 18개 항목을 보고한 문헌 이 7편, 17개 항목을 보고한 문헌이 2편 24,25) , 16개 항목 을 보고한 문헌이 1편 41) , 15개 항목을 보고한 문헌이 2 PRISMA 2020 지침에 근거한 한방재활의학과학회지 체계적 문헌고찰 보고의 질 평가 연구 편 43,49) , 14개 항목을 보고한 문헌이 3편 26,51,58) , 13개 항 목을 보고한 문헌이 3편 50,52,57) , 12개 항목을 보고한 문 헌이 2편 53,56) 이었다( 은 모든 문헌에서 보고되지 않았다(Fig.…”