The effect of oral simvastatin on fibrinolytic activity after colorectal surgery—a pilot study

Alexander, Zanazir; Su’a, Bruce; Hill, Caleb; Lyndon, Mataroria; Singh, Pushpendra; Hill, Andrew

doi:10.1016/j.jss.2016.05.037

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…However, inconsistent results exist in the literature regarding the oral administration of statins for the prevention of adhesion formation. Some experimental studies reported that oral simvastatin or fluvastatin reduced fibrosis in rotator cuff tears or laparotomy, respectively 21 , 22 , whereas there was studies reporting that oral simvastatin did show no effect on the fibrinolytic pathway in rats and human 20 , 40 .…”

Section: Discussionmentioning

confidence: 99%

“…It can provide the valuable evidence to research the effect of statin on postoperative adhesion for patients having statin due to dyslipidemia. There was a pilot clinical study investigating the effect of oral simvastatin after colorectal surgery 40 . There was no anti-adhesive effect of statin in this study, but further and more clinical trials are required.…”

Section: Discussionmentioning

confidence: 99%

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Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis

Choi

Park

Kim

et al. 2018

Sci Rep

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Adhesion is a significant concern after surgery. Many researchers studied the anti-adhesive effect of statin, of which results were inconsistent. Thus, we purposed to perform a systematic review and meta-analysis to evaluate the effect of statins on postoperative adhesion in an experimental study. A comprehensive search was conducted using MEDLINE, EMBASE, and Google Scholar to identify animal studies that investigated the postoperative anti-adhesive effect of statins applied at the surgical area. Primary outcome measure was gross adhesion score. Secondary outcomes included microscopic adhesion score and tissue plasminogen activator (t-PA) activity. Totally, 298 rats from 9 animal studies (172 rats received statin therapy and 126 rats received placebo or no treatment) were included in the final analysis. The combined results showed that gross and microscopic adhesion scores were significantly lower in the statin group in comparison to the control group (standardized mean difference [SMD] = 1.65, 95% confidence interval [CI]: 1.02 to 2.28, Pchi2 < 0.001, I2 = 77.9%; SMD = 1.90, 95% CI: 1.10 to 2.79, Pchi2 < 0.001, I2 = 84.5%, respectively). However, there was no evidence of a difference in t-PA activity (SMD = −3.43, 95% CI: −7.95 to 1.09, Pchi2 < 0.001, I2 = 95.5%). In conclusion, statins were effective in preventing postoperative adhesion, as assessed based on gross and microscopic adhesion scores in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis

Choi

Park

Kim

et al. 2018

Sci Rep

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“…A strong deterrent for using a solid adhesion barrier in patients with metabolic syndrome and therefore a proinflammatory state is the risk for rejection. There is, however, no real proof of the clinical benefit of flowable/liquid adhesion barriers over saline or other crystalloid solutions [34,35]. A different approach towards adhesion prevention is to attempt to use existing and approved pharmacological agents such as steroids [36,37] , and systemically applied antibiotic treatment [38,39].…”

Section: How Can We Better Manage Surgical Adhesion Prophylaxis In Pamentioning

confidence: 99%

Metabolic Syndrome is a Risk Factor for Post-Operative Adhesions: Need for Novel Treatment Strategies

Pilpel¹,

Pines

Birkenfeld

et al. 2018

Horm Metab Res

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Metabolic syndrome is a group of disorders which include obesity, diabetes, dyslipidemias, and hypertension. This condition is rapidly increasing in an aging population. The rates of surgery in older patients is also growing and a wide range of operations including minimally invasive procedures is now available for this segment of the population. The number of patients suffering from postoperative adhesions is therefore correspondingly increasing. In addition to preventing and treating the metabolic disease itself, improved therapeutic strategies for the prevention of surgical adhesions have to be developed. Here we review the existing and novel treatment options.

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Postoperative peritoneal adhesion: an update on physiopathology and novel traditional herbal and modern medical therapeutics

Soltany

2020

Naunyn-Schmiedeberg's Arch Pharmacol

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The effect of oral simvastatin on fibrinolytic activity after colorectal surgery—a pilot study

Cited by 4 publications

References 18 publications

Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis

Effect of statins on experimental postoperative adhesion: a systematic review and meta-analysis

Metabolic Syndrome is a Risk Factor for Post-Operative Adhesions: Need for Novel Treatment Strategies

Postoperative peritoneal adhesion: an update on physiopathology and novel traditional herbal and modern medical therapeutics

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