The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1

Steerenberg, P. A.; Garssen, Johan; Dortant, P.M.; Vliet, H. van der; Geerse, E.; Verlaan, A. P. J.; Goettsch, Wim; Sontag, Y.; Bueno‐de‐Mesquita, H. Bas; Loveren, Henk Van

doi:10.1016/s0304-3835(97)04659-4

Cited by 23 publications

(7 citation statements)

References 10 publications

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“…Since each of the 24 chemicals is a good UVB absorber (Bradfield and Penny 1948;Roberts and Williams 1958;Coxon et al 1972;Caffin et al 2004), it is likely that UVB absorbance plays a more important role in UV protection than antioxidant activity. For example, quercetin, which is found in tea, red wine, fruits, vegetables and herbs (Svobodova, Psotova, and Walterova 2003), prevented UVB-induced immunosuppression (Steerenberg et al 1997). Whether maximal UV protection was due to a single compound or to a combination of chemicals in aqueous extracts of green tea has yet to be determined.…”

Section: Discussionmentioning

confidence: 99%

Green tea extracts as ultraviolet protectants for the beet armyworm,Spodoptera exigua, nucleopolyhedrovirus

Shapiro

Salamouny

Shepard

2008

Biocontrol Science and Technology

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The addition of a caffeinated green tea, Camellia sinensis L., filtrate (1%) to the nucleopolyhedrovirus (SeMNPV) of the beet armyworm, Spodoptera exigua (Hü bner), provided almost complete protection following UVB irradiation (30 min) in laboratory tests. There were few differences in UV protection when extracts were prepared at 27 or at 908C. Moreover, few differences in UV protection were demonstrated following infusion times of 5, 15, 30, and 60 min at 908C. At a 1% concentration, decaffeinated and caffeinated green teas were equally effective as UV protectants. At lower concentrations (0.1, 0.01, and 0.001%) caffeinated green tea provided greater UV protection (UVB/UVB 30, 60 min). Virus/tea extracts (caffeinated), under field conditions at 1 and 5%, were ineffective as UV screens. At a 10% concentration, some UV protection was provided and UV protection further increased in a concentrationdependent manner.

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Section: Discussionmentioning

confidence: 99%

Green tea extracts as ultraviolet protectants for the beet armyworm,Spodoptera exigua, nucleopolyhedrovirus

Shapiro

Salamouny

Shepard

2008

Biocontrol Science and Technology

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“…Inal et al showed that quercetin protected skin antioxidant systems, namely glutathione peroxidase, glutathione reductase, catalase and superoxide dismutase activities, against UVA irradiating damage in rats to a considerable degree 11 . Oral intake of quercetin prevented UVB-induced immunosuppression in SKH-1 hairless mice 39 . In vitro, quercetin and its semisynthetic derivatives (quercetin 3-O-acetate, quercetin 3-O-propionate, quercetin 3-Opalmitate) were found to inhibit UVC radiation-induced peroxidation in liposomal membranes 40 .…”

Section: Quercetinmentioning

confidence: 90%

Natural phenolics in the prevention of UV-induced skin damage. A review

Svobodová¹,

Psotová²,

Walterová³

2003

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

377

262

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“…Qu is one representative flavonoid with anti-oxidant, anti-inflammation, and anti-tumor properties ( Formica and Regelson, 1995 ). Previous research has revealed that Qu is very effective against UVB radiation through downregulating COX-2 level in vitro ( Steerenberg et al, 1997 ). However, in vivo application of Qu is limited by its low hydrophilicity and poor percutaneous absorption ( Hung et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Topical Use of Quercetin-Loaded Chitosan Nanoparticles Against Ultraviolet B Radiation

et al. 2018

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Ultraviolet radiation is a major risk factor for human skin damage, especially solar ultraviolet-B (UVB) which can induce inflammation, photoaging, and skin cancer. Quercetin (Qu), one of flavonoid family members, has showed protective effects against UVB radiation. However, its application for topical use is limited by low hydrophilicity and poor percutaneous absorption. Herein, we found that Qu, if entrapped into TPP-Chitosan nanoparticles (TCs), can be efficiently uptake by HaCaT cells and easily permeate through the epidermis layer, meanwhile display better stability and low cytotoxicity. We also found that Qu-loaded TCs (QTCs) could notably enhance the effect of Qu on inhibiting the NF-kB/COX-2 signaling pathway as well as ameliorating the skin edema caused by UVB radiation. Therefore, this study provided a method to get rid of Qu’s low hydrophilicity, enhance its percutaneous absorption and retention in the skin, and further improve its anti-UVB effect, and demonstrated that Qu-loaded chitosan nanoparticles can be used as the therapeutic agent for topical use against UVB radiation.

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The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1

Cited by 23 publications

References 10 publications

Green tea extracts as ultraviolet protectants for the beet armyworm,Spodoptera exigua, nucleopolyhedrovirus

Green tea extracts as ultraviolet protectants for the beet armyworm,Spodoptera exigua, nucleopolyhedrovirus

Natural phenolics in the prevention of UV-induced skin damage. A review

Topical Use of Quercetin-Loaded Chitosan Nanoparticles Against Ultraviolet B Radiation

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