The effect of oral nutritional supplements on head and neck cancer

Arnold, Cathy; Richter, Mandy

doi:10.1016/0360-3016(89)90968-1

Cited by 58 publications

(53 citation statements)

References 7 publications

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“…The use of oral nutritional supplementation during definitive radiotherapy for head and neck cancer has been supported by data from a randomized controlled trial. 16 Serum albumin levels were maintained during and after treatment in the group receiving oral nutritional supplementation. Our results suggest a need for greater attention to nutritional management during organ preservation treatment to reduce surgical complications.…”

Section: Commentmentioning

confidence: 99%

Complications From Planned, Posttreatment Neck Dissections

Davidson¹,

Newkirk²,

Harter³

et al. 1999

Arch Otolaryngol Head Neck Surg

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Section: Commentmentioning

confidence: 99%

Complications From Planned, Posttreatment Neck Dissections

Davidson¹,

Newkirk²,

Harter³

et al. 1999

Arch Otolaryngol Head Neck Surg

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“…These data were analysed after completion and publication of the meta-analysis and are therefore reported according to the original studies. Six studies examined the efficacy of nutritional interventions in terms of response to anti-tumour treatment and there were no differences between groups in any study (24)(25)(26)(27)(28)31) . Four studies assessed the effects of nutritional interventions on treatment interruptions and there were no statistically significant differences between groups, although two studies (29,30) reported more days of treatment interruptions in patients receiving routine care than in those receiving intervention.…”

Section: Effects On Outcomes Of Cancer Treatmentmentioning

confidence: 99%

The effectiveness of nutritional interventions in malnutrition and cachexia

Baldwin

2015

Proc. Nutr. Soc.

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Conference on 'Nutrition and age-related muscle loss, sarcopenia and cachexia' Symposium 3: Nutrition for prevention and interventions for sarcopenia and cachexiaThe effectiveness of nutritional interventions in malnutrition and cachexia There are similarities and differences between definitions of both malnutrition and cachexia and studies of oral nutritional interventions have failed to use standard criteria at study inclusion contributing to heterogeneity amongst studies. Meta-analysis of randomised controlled trials has suggested limited evidence of benefit to nutritional and clinical outcomes but some improvements to aspects of quality of life. The presence of cachexia in patients with cancer might explain the limited efficacy of simple oral nutritional interventions, which lack a component designed to address metabolic abnormalities associated with cachexia. Novel strategies combining nutritional support with therapeutic agents designed to down-regulate the metabolic aberrations have failed to demonstrate consistent benefits and the results of multimodal treatments combining several interventions are awaited. There is a need for intervention studies recruiting patients early in the disease course, which underlines the need for definitions which predict poor outcome and hence allow early recognition of vulnerable patients. Christine Baldwin Malnutrition: Cachexia: Oral nutritional support: Systematic review: Meta-analysisThe most recent data indicate that worldwide there were about 14 million new cases of cancer diagnosed in 2012 and greater than 330 000 diagnoses being made in the UK in 2011 (1,2) . Cancer remains a leading cause of death worldwide and it is estimated that that 8·2 million people died from cancer in 2012 with about 162 000 deaths from cancer in the UK (1) . Despite the dismal nature of these data, more than half of people diagnosed with cancer will survive for 10 years or more; (1) therefore efforts to maximise the ability of patients to respond to treatment and to achieve a good quality of life are paramount. The morbidity experienced by people with cancer arises from the presence of disease and from the side-effects of treatment. The presence, number and intensity of symptoms are likely to account for a large amount of the suffering experienced by patients. Weight loss is a common symptom in people diagnosed with cancer. A pooled prevalence for any amount of weight loss of 46 (95 % CI 34, 59) % was reported by a systematic review of symptom prevalence in people with incurable cancer (3) . Amounts of weight loss vary according to the site and stage of disease. A retrospective review of 3047 patients with different cancers entering clinical trials, reported a prevalence varying from 31 % to 87 % with the greatest amounts of weight loss found in patients with cancers of the upper gastrointestinal tract (4) . In a group of patients with advanced

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“…Following ONS, weight gain varied considerably and depended on the duration and amount of supplementation, and the disease status of patients. Mean percentage weight change in supplemented patients compared with unsupplemented control patients could be calculated in twenty-two randomized controlled studies of adults (duration of ONS 10 d-1 year, n 900 patients; Douglass et al 1978;Foster et al 1980;Elkort et al 1981;Simko, 1983;Lewis et al 1987;Norregaard et al 1987;Efthimiou et al 1988;Knowles et al 1988;Arnold & Richter, 1989;Donahoe et al 1989;Otte et al 1989;Fuenzalida et al 1990;Nayel et al 1992;Rogers et al 1992;Hirsch et al 1993;Fiatarone et al 1994;Woo et al 1994;Gray-Donald et al 1995;Volkert et al 1996;Jensen & Hessov, 1997;Keele et al 1997;Rabeneck et al 1998). The mean percentage weight change of patients receiving ONS (2·93 %) was greater than that of the unsupplemented control patients (1·15 %, mean difference 1·77, range −2·69 to 9·2 %; weighted for the number of subjects in each category).…”

Section: Outcome Measuresmentioning

confidence: 99%

Summary of a systematic review on oral nutritional supplement use in the community

Stratton

2000

Proc. Nutr. Soc.

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Despite a marked increase in the prescription of oral nutritional supplements (ONS) in the community (Department of Health, 1991–7), there is still uncertainty about the value of their use in patients with different diseases. To answer questions about the effects on ONS on body weight and structure, spontaneous food intake and body function, a critical systematic review was undertaken (Stratton & Elia, 1999a). Eighty-four trials were reviewed (forty-five randomized, thirty-nine non-randomized; 2570 patients; diagnoses including chronic obstructive pulmonary disease, Crohn’s disease, cystic fibrosis, human immunodeficiency virus and acquired immune deficiency syndrome and cancer). Most studies (83 %) were conducted in patients living at home. The supplements were typically mixed macronutrients in liquid form, providing < 0.42–10.5 MJ/d for 1 week–2 years. The studies reviewed in patients with predominantly chronic conditions living in the community suggested that: (1) ONS produce demonstrable clinical (including functional) benefits, but the nature and extent of these benefits varies with the underlying chronic condition; (2) ONS increase total energy intake with > 50 % of the energy from ONS typically additional to that from habitual food intake; (3) improvements in body weight, total energy intake and body function following ONS appear to occur more frequently in individuals with a BMI < 20 kg/m2 than in those with a BMI > 20 kg/m2.

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The effect of oral nutritional supplements on head and neck cancer

Cited by 58 publications

References 7 publications

Complications From Planned, Posttreatment Neck Dissections

Complications From Planned, Posttreatment Neck Dissections

The effectiveness of nutritional interventions in malnutrition and cachexia

Summary of a systematic review on oral nutritional supplement use in the community

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