The effect of oral N-acetylcystein on prevention of extensive tissue destruction in electrical burn injury

Saputro, Iswinarno Doso; Riestiano, B.; Hoekstra, Lisette T.; Zarasade, Lobredia

doi:10.1016/j.burns.2018.08.025

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Burns cause severe tissue injury that can trigger hypermetabolic processes and immune response that require fast and effective treatment to reduce the risk of mortality. According to the cause, burns most often occurs due to fire and electric current [14,15]. Ibara et al said that the most common cause of burns was due to flames in both developed and developing countries [16].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Bernadetta¹,

Saputro²,

Zarasade³

2023

IJRP

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BACKGROUND Complications like sepsis due to infection and death can occur in the treatment of major burn trauma patients because of inflammation process. The Neutrophil-to-Lymphocyte Ratio (NLR) is believed as a prognostic marker for the incidence of mortality and sepsis in burns patient care. Various studies have stated that NLR is quite easy, inexpensive and efficient tool for clinical application. AIMS to analyze the role of NLR as prognostic marker for mortality and sepsis in burn patients. METHODS A cross-sectional retrospective single-center study was conducted between 2019 -2021 using 222 medical records from 245 burn patients at our Burns Unit. Demographics and laboratory data results were recorded, including NLR levels on 1 st and 3 rd day of treatment. Correlation analysis of NLR levels was carried out on the incidence of mortality and sepsis using Logistic Regression and Chi Square tests. RESULTSThe subjects of this study were dominated by patients with median age of 33 years old (SD ±20), male (68.5%) and average burns area of 30.22% (SD ±23.3%). This study noted that the NLR on 1 st day (cutoff of 7.97) and 3 rd day (cutoff of 6.2) of treatment had a correlation with the incidence of mortality and sepsis (p<0.05). CONCLUSION Neutrophil-to-Lymphocyte Ratio (NLR) can be used as a prognostic marker of mortality and sepsis in burn patients.

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Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Bernadetta¹,

Saputro²,

Zarasade³

2023

IJRP

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“…Furthermore, there is an increased need for different imaging modalities that may better characterize and predict burn wound depth and assist in clinical decision-making. -Conjugated TNF-α antibodies with hyaluronic acid (HA) in a topical application; [26] -Hyaluronic acid-conjugated anti-IL-6 and TNF-α antibodies conjugated antibodies [27] -TNF-α and leukocytes transmigration -Cerium Nitrate [28,29] -IL-6 -Antibodies vs. IL-6 [4] -Inflammatory mediators and sequestration of neutrophils -Oil-in-water nano emulsion formulation (NB-201) containing benzalkonium chloride [30] -NLRP3 inflammasome activation -3,4-methylenedioxy-β-nitrostyrene [31] -Neutrophil infiltration, proinflammatory cytokine production, and upregulation of anti-inflammatory cytokines -Mesenchymal stem cells [101] Ischemia -Impaired tissue perfusion -Fluid resuscitation [37][38][39][40] -Desiccation -Allogeneic keratinocytes cultured on acellular xenodermis [41] -Increase in nitric oxide synthase expression with decreased inflammation -Erythropoietin [7,42] -Cellular Injury -Poloxamer 188 (P188) [46] -Endothelin A, and endothelin B -TAK-044 [48] -Adenosine triphosphate-sensitive K + channel -Nicorandil [49] T-cells and macrophages -IL-6 and TNF-α expression -Metal chelation [24,58] Reactive Oxygen Species (ROS) -Reduction in ROS -N-acetylcysteine (NAC); [78][79][80][81][82] -Curcumin; [87] -Curcumin-treated adipose-derived stem cells [89] -Metal chelation [25] -Hydrogel with embedded iron-coordinated superoxide dismutase and Vitamin E; [90] -Carboxymethyl chitosan hydrogel, [91] -Methylene blue intradermal injections [92] -Mesenchymal stem cells [101] Author Contributions:…”

Section: Discussionmentioning

confidence: 99%

“…In a full-thickness mouse burn model, Landriscina and colleagues demonstrated that NAC attenuated wound expansion and accelerated wound healing by advancing the proliferative phase of wound healing and increased collagen deposition [ 78 ]. In another murine model, Saputro et al showed that NAC administration immediately after injury reduced the necrotic zone and limited tissue damage compared to controls by attenuating the overall ROS burden in the wound [ 79 ]. The beneficial effects of NAC on wound healing and reduction of ROS generation in the zone of stasis were corroborated in various studies [ 80 , 81 , 82 ].…”

Section: Reactive Oxygen Speciesmentioning

confidence: 99%

Therapeutic Strategies to Reduce Burn Wound Conversion

et al. 2022

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Burn wound conversion refers to the phenomenon whereby superficial burns that appear to retain the ability to spontaneously heal, convert later into deeper wounds in need of excision. While no current treatment can definitively stop burn wound conversion, attempts to slow tissue damage remain unsatisfactory, justifying the need for new therapeutic interventions. To attenuate burn wound conversion, various studies have targeted at least one of the molecular mechanisms underlying burn wound conversion, including ischemia, inflammation, apoptosis, autophagy, generation of reactive oxygen species, hypothermia, and wound rehydration. However, therapeutic strategies that can target various mechanisms involved in burn wound conversion are still lacking. This review highlights the pathophysiology of burn wound conversion and focuses on recent studies that have turned to the novel use of biologics such as mesenchymal stem cells, biomaterials, and immune regulators to mitigate wound conversion. Future research should investigate mechanistic pathways, side effects, safety, and efficacy of these different treatments before translation into clinical studies.

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“…This patient was administered NAC as recommended by poison control. NAC has been used successfully in the treatment of acetaminophen overdose, smoke inhalation injury, and burns, among other conditions [ 5 , 8 - 9 ]. NAC exerts its healing effects by acting as an antioxidant as well as an inflammatory mediator, making it a reasonable recommendation for conditions where salvage of damaged or at-risk tissues is necessary [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of N-acetylcysteine in the Treatment of Accidental Submersion of the Hands in Liquid Nitrogen

Orozco¹,

Birnbrich²,

Liberman³

2021

Cureus

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N-acetylcysteine (NAC) is a compound with numerous uses, especially in cases which require prevention of cellular damage. To the authors’ knowledge, no reports of NAC as treatment for liquid nitrogen (LN2) injuries currently exist. We present a case in which a 40-year-old woman accidentally submerged her hands in LN2 while working in a lab. The patient was treated with NAC, antibiotics, and wound care. Six months post-injury, the patient had full range of motion, full sensation, full function, and no pain. Therefore, NAC, in combination with dressing changes and antibiotics, can be used to successfully treat patients with LN2 burns.

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The effect of oral N-acetylcystein on prevention of extensive tissue destruction in electrical burn injury

Cited by 7 publications

References 11 publications

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Therapeutic Strategies to Reduce Burn Wound Conversion

The Role of N-acetylcysteine in the Treatment of Accidental Submersion of the Hands in Liquid Nitrogen

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