The effect of oral melatonin supplementation on MT-ATP6 gene expression and IVF outcomes in Iranian infertile couples: a nonrandomized controlled trial

Hosseini, Fatemeh; Shamsipour, Mansour; Yazdekhasti, Hossein; Akbari-Asbagh, Firoozeh; Shahraki, Zahra; Aghaee‐Bakhtiari, Seyed Hamid

doi:10.1007/s00210-021-02071-9

Cited by 5 publications

(3 citation statements)

References 40 publications

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“…According to a meta‐analysis including randomized control trial, oral melatonin supplements during IVF increase the number of mature oocytes, albeit not significant 111 . On the other hand, one study showed that the proportion of mature oocytes (metaphase II stage oocytes/total retrieved oocytes) did not change after melatonin supplementation, and the biochemical pregnancy rate was not significantly higher in the group that received melatonin supplementation 112 …”

Section: Therapeutics Involving the Sirt Signaling Pathway To Improve...mentioning

confidence: 99%

“… 111 On the other hand, one study showed that the proportion of mature oocytes (metaphase II stage oocytes/total retrieved oocytes) did not change after melatonin supplementation, and the biochemical pregnancy rate was not significantly higher in the group that received melatonin supplementation. 112 …”

Section: Therapeutics Involving the Sirt Signaling Pathway To Improve...mentioning

confidence: 99%

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Improvement of oocyte quality through the SIRT signaling pathway

Sato

Kawamura

2023

Reprod Medicine & Biology

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Background Oocyte quality is one of the major deciding factors in female fertility competence. Methods PubMed database was searched for reviews by using the following keyword “oocyte quality” AND “Sirtuins”. The methodological quality of each literature review was assessed using the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) 2020 statement. Main Findings Oxidative stress has been recognized as the mechanism attenuating oocyte quality. Increasing evidence from animal experiments and clinical studies has confirmed the protective roles of the sirtuin family in improving oocyte quality via an antioxidant effect. Conclusion The protective roles in the oocyte quality of the sirtuin family have been increasingly recognized.

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Section: Therapeutics Involving the Sirt Signaling Pathway To Improve...mentioning

confidence: 99%

Section: Therapeutics Involving the Sirt Signaling Pathway To Improve...mentioning

confidence: 99%

Improvement of oocyte quality through the SIRT signaling pathway

Sato

Kawamura

2023

Reprod Medicine & Biology

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“…Compared with the previous IVF-ET cycle, melatonin treatment increased fertilization rate, and the concentrations of 8-hydroxy-2'- deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct in follicles were significantly reduced, which suggests that melatonin treatment can protect oocyte from free radical damage, improve mitochondria, and increase fertilization rate ( 235 ). Another clinical trial showed that supplementing with melatonin did not increase the mRNA level of the MT-ATP6 gene in CCs of ovarian follicles, as well as the likelihood of clinical pregnancy and the number of retrieved mature oocyte, but significantly reduced the number of low-quality embryos ( 236 ).…”

Section: Focus On Mitochondria Of Human Oocyte During Assisted Reprod...mentioning

confidence: 99%

Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions

Ju,

Zhao,

et al. 2024

Front. Endocrinol.

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Mitochondria plays an essential role in regulating cellular metabolic homeostasis, proliferation/differentiation, and cell death. Mitochondrial dysfunction is implicated in many age-related pathologies. Evidence supports that the dysfunction of mitochondria and the decline of mitochondrial DNA copy number negatively affect ovarian aging. However, the mechanism of ovarian aging is still unclear. Treatment methods, including antioxidant applications, mitochondrial transplantation, emerging biomaterials, and advanced technologies, are being used to improve mitochondrial function and restore oocyte quality. This article reviews key evidence and research updates on mitochondrial damage in the pathogenesis of ovarian aging, emphasizing that mitochondrial damage may accelerate and lead to cellular senescence and ovarian aging, as well as exploring potential methods for using mitochondrial mechanisms to slow down aging and improve oocyte quality.

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