The effect of oral Contraceptive pills and the natural menstrual cYCLe on arterial stiffness and hemodynamICs (CYCLIC)

Yu, Alice; Giannone, Tania; Scheffler, Patrick; Doonan, R.J.; Egiziano, Giordano; Gomez, Yessica-Haydee; Papaioannou, Theodore G.; Daskalopoulou, Stella S.

doi:10.1097/hjh.0000000000000012

Cited by 27 publications

(29 citation statements)

References 45 publications

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“…To our knowledge, only three studies have examined arterial stiffness in relation to estrogen contraceptive use. As was the case in our population (Table 1), one of the studies found a higher PWV among estrogen contraceptive users [46], while two studies [47,48] found no such difference. In summary, any possible estrogen effect on vascular status measures is likely subtle in premenopausal women.…”

Section: Discussionsupporting

confidence: 82%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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Background: Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults. Methods: Pulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0-25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses. Results: The cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS. Conclusions: A VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.

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Section: Discussionsupporting

confidence: 82%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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“…Our study has several strengths, including the objective measurement of physical activity, the use of a validated measure of arterial stiffness, with which we have extensive experience in our Vascular Lab [22,48–51], and our ability to account for a variety of demographic factors, and also specific antihypertensive, antihyperglycemic, and lipid-lowering therapies.…”

Section: Discussionmentioning

confidence: 99%

Carotid femoral pulse wave velocity in type 2 diabetes and hypertension

Dasgupta

Rosenberg²,

Joseph³

et al. 2017

Journal of Hypertension

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Objective:Optimal medication use obscures the impact of physical activity on traditional cardiometabolic risk factors. We evaluated the relationship between step counts and carotid-femoral pulse wave velocity (cfPWV), a summative risk indicator, in patients with type 2 diabetes and/or hypertension.Research design and methods:Three hundred and sixty-nine participants were recruited (outpatient clinics; Montreal, Quebec; 2011–2015). Physical activity (pedometer/accelerometer), cfPWV (applanation tonometry), and risk factors (A1C, Homeostatic Model Assessment–Insulin Resistance, blood pressure, lipid profiles) were evaluated. Linear regression models were constructed to quantify the relationship of steps/day with cfPWV.Results:The study population comprised 191 patients with type 2 diabetes and hypertension, 39 with type 2 diabetes, and 139 with hypertension (mean ± SD: age 59.6 ± 11.2 years; BMI 31.3 ± 4.8 kg/m2; 54.2% women). Blood pressure (125/77 ± 15/9 mmHg), A1C (diabetes: 7.7 ± 1.3%; 61 mmol/mol), and low-density lipoprotein cholesterol (diabetes: 2.19 ± 0.8 mmol/l; without diabetes: 3.13 ± 1.1mmol/l) were close to target. Participants averaged 5125 ± 2722 steps/day. Mean cfPWV was 9.8 ± 2.2 m/s. Steps correlated with cfPWV, but not with other risk factors. A 1000 steps/day increment was associated with a 0.1 m/s cfPWV decrement across adjusted models and in subgroup analysis by diabetes status. In a model adjusted for age, sex, BMI, ethnicity, immigrant status, employment, education, diabetes, hypertension, medication classes, the mean cfPWV decrement was 0.11 m/s (95% confidence interval −0.2, −0.02).Conclusions:cfPWV is responsive to step counts in patients who are well controlled on cardioprotective medications. This ability to capture the ‘added value’ of physical activity supports the emerging role of cfPWV in arterial health monitoring.

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“…Specifically, the micromanometer records radial (peripheral) pressure waveforms, which are averaged and mathematically transformed using a generalized transfer function to derive an aortic (central) waveform . Mean arterial pressure (MAP), heart rate, and central AIx (cAIx) were also determined using the SphygmoCor software system …”

Section: Methodsmentioning

confidence: 99%

“…16 Mean arterial pressure (MAP), heart rate, and central AIx (cAIx) were also determined using the SphygmoCor software system. [17][18][19] Covariates A history of physician-diagnosed stroke, myocardial infarction, chest pain, and renal disease was assessed by questionnaires. Participants who had been diagnosed with at least one of the above health conditions were classified as having one or more comorbidities.…”

Section: Hypertension Assessment and Bp Measurementsmentioning

confidence: 99%

Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross‐Sectional Analysis Among Nondiabetic Patients

Moura

Daskalopoulou

Lévesque

et al. 2015

J of Clinical Hypertension

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Thiazide diuretics (TDs) are a cost-effective first-line therapy for uncomplicated hypertension; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTa-GENE project was used. Nondiabetic hypertensive participants on monotherapy for hypertension were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 hypertensive participants, 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, À1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated hypertension. J Clin Hypertens (Greenwich). 2015;17:848-854. ª 2015 Wiley Periodicals, Inc.Elevated blood pressure (BP) is a well-known predictor of cardiovascular risk and mortality and lowering BP is an effective means of reducing cardiovascular events.

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The effect of oral Contraceptive pills and the natural menstrual cYCLe on arterial stiffness and hemodynamICs (CYCLIC)

Cited by 27 publications

References 45 publications

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Carotid femoral pulse wave velocity in type 2 diabetes and hypertension

Comparison of the Effect of Thiazide Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross‐Sectional Analysis Among Nondiabetic Patients

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