The Effect of Opioid Prescribing Guidelines on Prescriptions by Emergency Physicians in Ohio

National Variation in Opioid Prescribing and Risk of Prolonged Use for Opioid-Naive Patients Treated in the Emergency Department for Ankle Sprains

“…The interpretation of this finding is that for approximately every 26 patients exposed to greater than 225 MME (the equivalent of more than 30 tabs of oxycodone 5 mg) instead of 75 MME or less (equivalent to 10 tablets of oxycodone 5 mg) 1 additional patient transitioned to prolonged use. While there is room for improvement in promoting opioid stewardship for this minor condition in the ED, the majority of prescriptions written were concordant with guidelines for a 3-day supply 12,13,31 and had a low total MME of 100 or less. Therefore, more research is urgently needed to examine the relationship between total MME, prolonged use, and adverse events in other contexts, such as for post-operative pain, where prescriptions are much larger.…”

Chronic opioid use following anterior cervical discectomy and fusion surgery for degenerative cervical pathology

“…Even before recent initiatives spurred by the opioid epidemic, it has been well demonstrated that widespread geographic variation in opioid prescribing exists in the United States, beyond what can be explained by differences in the number of physicians or injury and surgery prevalence [29]. Individual states have the ability to influence opioid prescribing by implementing guidelines and continuing education for physicians [17,30]. In addition, the efficiency of prescription drug monitoring programs varies between states [31], and complex socioeconomic factors may contribute to differences patients who use opioids chronically [31,32].…”

Association of a Risk Evaluation and Mitigation Strategy Program With Transmucosal Fentanyl Prescribing

“…This allows the preintervention level and trend to serve as a predictor of the counterfactual, ie, what would have been without the intervention. 17 Additional details on the models used are included in eAppendix 3 in the Supplement.…”