The Effect of Ophthalmic Surgery for Graves' Orbitopathy on Quality of Life: A Systematic Review and Meta-Analysis

Thyroid eye disease (TED) remains challenging for clinicians to evaluate and manage. Novel therapies have recently emerged, and their specific roles are still being determined. Most patients with TED develop eye manifestations while being treated for hyperthyroidism and under the care of endocrinologists. Endocrinologists, therefore, have a key role in diagnosis, initial management, and selection of patients who require referral to specialist care. Given that the need for guidance to endocrinologists charged with meeting the needs of patients with TED transcends national borders, and to maximize an international exchange of knowledge and practices, the American Thyroid Association and European Thyroid Association joined forces to produce this Consensus Statement.

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“…Not all patients require all procedures. QOL improvements often occur as a result of surgical rehabilitation for TED ( 135 , 136 ).…”

Section: Management Of Moderate-to-severe Tedmentioning

confidence: 99%

“…Not all patients require all procedures. QOL improvements often occur as a result of surgical rehabilitation for TED (135,136). Key Point 7.3.1.1: Surgery for moderate-to-severe TED should be performed by an orbital surgeon experienced with these procedures and their complications.…”

Section: Surgical Intervention Overviewmentioning

confidence: 99%

Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association

Burch

Perros

Bednarczuk

et al. 2022

European Thyroid Journal

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“…Numerous studies of benign thyroid diseases have demonstrated deficits in multiple QoL domains (4)(5)(6)(40)(41)(42)(43). In this section we discuss a few selected studies that have examined the impact of treatment on QoL.…”

Section: Important Qol Issues In Benign Thyroid Diseasesmentioning

confidence: 99%

“…According to the US Food and Drug Administration, "a PRO is a measurement of any aspect of a patient's health status that comes directly from the patient (i.e., without the interpretation of the patient's responses by a physician or anyone else)" (1). The prognosis of benign thyroid diseases, including hypothyroidism, is generally good with appropriate treatment, although many patients experience major QoL impairments at the time of disease presentation (2)(3)(4)(5)(6). Furthermore, despite good biochemical management and/or definitive treatment (e.g.…”

Section: Introductionmentioning

confidence: 99%

Implementation of thyroid-related patient-reported outcomes in routine clinical practice

et al. 2022

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Patient-reported outcomes (PROs) are increasingly used in clinical practice to improve clinical care. Multiple studies show that systematic use of PROs can enhance communication with patients and improve patient satisfaction, symptom management and quality of life. Further, such data can be aggregated to examine health levels for patient groups, improve quality of care, and compare patient outcomes at the institutional, regional or national level. However, there are barriers and challenges that should be handled appropriately to achieve successful implementation of PROs in routine clinical practice. This paper briefly overviews thyroid-related PROs, describes unsolved quality of life issues in benign thyroid diseases, provides examples of routine collection of PROs, and summarizes key points facilitating successful implementation of thyroid-related PROs in routine clinical practice. Finally, the paper touches upon future directions of PRO research.

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“…A robust, valid, and reliable patient-centered QOL measure would go a long way toward enacting a shift to more thorough assessment of TED disease states and the influence of clinical management on it. To date, only the GO-QOL and TED-QOL ( 52 ) have been correlated with clinical outcome, with the GO-QOL utilized the most in clinical trials ( 10 , 40 , 42 , 43 , 45 , 57 ).…”

Section: Opportunities and Challengesmentioning

confidence: 99%

Measuring Health-Related Quality of Life in Thyroid Eye Disease

Sharma

Stan

Rootman

2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Health-related quality of life (HQOL) is a concept that aims to understand the totality of an individual’s experience of their disease state. This can include the physical, psychosocial, emotional, and psychological effects of a disease state. A complex and multifactorial concept, HQOL can be challenging to measure accurately and reliably. Thyroid eye disease (TED), as a multifaceted physically debilitating and facial disfiguring disorder, presents unique challenges and opportunities in the measurement of HQOL. Multiple distinct tools have been developed for this purpose, each has been constructed, assessed, and utilized. This discussion surveys the landscape of TED-related QOL measurement and presents challenges for the future. Clinicians and clinical researchers should implement TED-related QOL measurement as part of routine TED care and as a primary outcome in TED clinical trials. We recommend utilizing the Graves’ ophthalmopathy (GO)-QOL routinely in clinical practice and as a primary outcome in TED clinical trials. If the GO-QOL is too time-consuming or in mild TED, a faster alternative is the TED-QOL.

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The Effect of Ophthalmic Surgery for Graves' Orbitopathy on Quality of Life: A Systematic Review and Meta-Analysis

Cited by 14 publications

References 31 publications

Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association

Management of thyroid eye disease: a Consensus Statement by the American Thyroid Association and the European Thyroid Association

Implementation of thyroid-related patient-reported outcomes in routine clinical practice

Measuring Health-Related Quality of Life in Thyroid Eye Disease

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