The effect of omeprazole on gastric myoelectrical activity and emptying

Kamiya, Tetsuro; Shikano, Michiko; Tanaka, Mamoru; Tsukamoto, Hironobu; Ebi, Masahide; Hirata, Yoshikazu; Mizushima, Takashi; Murakami, Kenji; Shimura, Takaya; Mizoshita, Tsutomu; Mori, Yoshinori; Tanida, Satoshi; Kato, Takashi; Imaeda, Kazuo; Kataoka, Hiromi; Joh, Takashi

doi:10.1540/jsmr.47.79

Cited by 8 publications

(6 citation statements)

References 31 publications

(34 reference statements)

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“…However, in this study, in relation to the animals treated with THERM (100 mg/kg), pretreatment with omeprazole (20 mg/kg), a proton pump (H + ,K + -ATPase) inhibitor, did not affect the reduction of THERM-induced emptying (30.5 ± 3.0% vs. 35.5 ± 6.3%, P > 0.05). Moreover, as described by Kamiya et al. (2011) , we found that pretreatment with omeprazole did not interfere in GE (50.2 ± 2.6% vs. 56.6 ± 3.6%, P > 0.05).…”

Section: Discussionsupporting

confidence: 81%

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Sousa

Sant'ana

Santos

et al. 2021

Current Research in Pharmacology and Drug Discovery

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Fat burners are a category of nutritional supplements that are claimed to increase the metabolism and promote greater energy expenditure, leading to weight loss. However, little is known about the side effects on gastrointestinal motility. In this study, we evaluated the effect of ingestion with a fat burner named Thermbuterol® (THERM) on the gastric motility and food behavior of mice. THERM compounds were identified using nuclear magnetic resonance (NMR). Mice received variable doses of THERM (10, 50, 100 or 300 mg/kg, p.o.) or NaCl 0.15 M (control). Gastric emptying (GE) was assessed using the phenol red technique. Another set of mice was pretreated with intraperitoneal administration of hexamethonium (HEXA, 10 mg/kg), prazosin (PRAZ, 0.25 mg/kg), propranolol (PROP, 2 mg/kg), parachlorophenylalanine (PCPA, 300 mg/kg) or ondansetron (ONDA, 50 μg/kg) 30 min before THERM treatment for evaluation of GE. We assessed the gastrointestinal responsiveness in vitro as well as THERM's effects on food behavior. Caffeine was the major compound of THERM, identified by NMR. THERM 100 and 300 mg/kg decreased GE compared to the respective controls. Pretreatment with PRAZ or PROP did not prevent gastric dysmotility induced by THERM 100 mg/kg. However, the pretreatment with HEXA, ONDA or PCPA prevented GE delay induced by THERM. In vitro , THERM relaxed contractions in strips of longitudinal gastric fundus and duodenum. THERM also increased food intake, which was prevented by PCPA and ONDA treatments. THERM decreased GE of a liquid and increased food intake in mice, a phenomenon mediated by the autonomic nicotinic receptors and serotoninergic receptor.

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Section: Discussionsupporting

confidence: 81%

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Sousa

Sant'ana

Santos

et al. 2021

Current Research in Pharmacology and Drug Discovery

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“…These effects of omeprazole may be one of the mechanisms involved in its efficacy in relieving dyspeptic symptoms in patients with functional dyspepsia [90]. …”

Section: Validation Of Eggmentioning

confidence: 99%

Electrogastrography in Adults and Children: The Strength, Pitfalls, and Clinical Significance of the Cutaneous Recording of the Gastric Electrical Activity

Riezzo

Russo

Indrio

2013

BioMed Research International

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Cutaneous electrogastrography (EGG) is a non-invasive technique to record gastric myoelectrical activity from the abdominal surface. Although the recent rapid increase in the development of electrocardiography, EGG still suffers from several limitations. Currently, computer analysis of EGG provides few reliable parameters, such as frequency and the percentage of normal and altered slow wave activity (bradygastria and tachygastria). New EGG hardware and software, along with an appropriate arrangement of abdominal electrodes, could detect the coupling of the gastric slow wave from the EGG. At present, EGG does not diagnose a specific disease, but it puts in evidence stomach motor dysfunctions in different pathological conditions as gastroparesis and functional dyspepsia. Despite the current pitfalls of EGG, a multitasking diagnostic protocol could involve the EGG and the 13C-breath testing for the evaluation of the gastric emptying time—along with validated gastrointestinal questionnaires and biochemical evaluations of the main gastrointestinal peptides—to identify dyspeptic subgroups. The present review tries to report the state of the art about the pathophysiological background of the gastric electrical activity, the recording and processing methodology of the EGG with particular attention to multichannel recording, and the possible clinical application of the EGG in adult and children.

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“…This has to be addressed in further studies. Although one study showed that administration of omeprazole did not affect gastric motility, 23 we cannot fully rule out that proton pump inhibitors can influence gastric emptying and gastric symptoms.…”

Section: Discussionmentioning

confidence: 86%

Gastric dysmotility in Parkinson's disease is not caused by alterations of the gastric pacemaker cells

Heimrich

Jacob

Schaller

et al. 2019

npj Parkinsons Dis.

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The enteric nervous system is involved in the pathology of Parkinson´s disease and patients frequently have symptoms related to delayed gastric emptying. However, the pathophysiology of gastric dysmotility is yet not well understood. The objective of this study was to assess interdigestive gastric motility in Parkinson´s disease. Using an electromagnetic capsule system, the dominant gastric contraction frequency (primary outcome measure) and the gastric transit time were assessed in 16 patients with Parkinson´s disease and 15 young healthy controls after a fasting period of 8 h. Motor and non-motor symptoms were assessed using the Movement Disorder Society Unified Parkinson´s Disease Rating Scale III (MDS-UPDRS III), the Non-Motor Symptoms Questionnaire (NMS-Quest), and Hoehn & Yahr staging. The Gastroparesis Cardinal Symptom Index was used to record symptoms related to delayed gastric emptying. In healthy controls and patients with Parkinson's disease, the dominant contraction frequency was 3.0 cpm indicating normal function of interstitial cells of Cajal. In patients with Parkinson's disease, the gastric transit time was longer than in younger controls (56 vs. 21 min). The dominant contraction frequency and gastric transit time did not correlate with age, disease duration, Hoehn & Yahr stage, levodopa equivalent daily dose, MDS-UPDRS III, NMS-Quest, and Gastroparesis Cardinal Symptom Index. Changes of gastric motility in Parkinson´s disease are not caused by functional deficits of the gastric pacemaker cells, the interstitial cells of Cajal. Therefore, gastroparesis in Parkinson's disease can be attributed to disturbances in neurohumoral signals via the vagus nerve and myenteric plexus.

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The effect of omeprazole on gastric myoelectrical activity and emptying

Cited by 8 publications

References 31 publications

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Involvement of serotonergic pathways in gastric dysmotility induced by fat burning nutritional supplements in mice

Electrogastrography in Adults and Children: The Strength, Pitfalls, and Clinical Significance of the Cutaneous Recording of the Gastric Electrical Activity

Gastric dysmotility in Parkinson's disease is not caused by alterations of the gastric pacemaker cells

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