The effect of olivine on the lungs of rats

Hydrothermal Processes: The Development of Geochemical Concepts in the Latter Half of the Twentieth Century

“…He provided the first tables of elemental abundances in eight monographs, "Geochemische Verteilungsgesitze der Elemente" (Geochemical Distribution of Elements) . Demonstrating his versatility, Victor opened a new interdisciplinary field by research with a physician to resolve the role of minerals in the development of lung ailments among workers in a glass factory (King et al ., 1945) .…”

Effect of Aluminium on the Silicosis-Producing Action of Inhaled Quartz

“…§ Heavy peribronchial fibrosis. aluminium according to the micro-analytical procedures outlined by King (1947) (Tables 1 and 2). Pathological Findings The results of the experiment are summarized in Table 3, in which the findings in quartz-dusted rats are compared with those in rats dusted with quartzplus-aluminium.…”

“…But it was pointed out by King (1947), in similar experiments, that the aluminium might disappear from the lungs of animals which had received a single dose of mixed quartz and aluminium by the intratracheal route, leaving the quartz behind to exert its fibrogenic action after all the aluminium had been dissolved. It may be, therefore, that aluminium can exert its preventive or retardative action on silicosis production only if it is constantly renewed in small amounts in the lungs.…”

“…At present, it seems certain that, like Denny and others, we have greatly retarded silicosis development, since there was just as much dust, found by analysis as well as by microincineration, in the lungs of quartz-plus-aluminiumdusted animals as in those dusted with quartz (Table 4). 1-6 9 2-4 0-08 13 2-1 13 2-6 0-10 14 2-0 14 3 0 0-12 15 1-5 15 3-1 0-13 16 2 1 16 2-6 0-08 *All lung tissue not used for histology was dried at 105°C, powdered, dried again to constant weight, re-ground, well mixed, and analysed for silica by the method of King (1939) and for aluminium by that of Alten and others (1933) as modified by King, 1947. The bearing of this and similar investigations on the problem of human silicosis can only be discussed very briefly. Following on Denny and others' demonstration of prevention of silicosis with aluminium in animals, large-scale prophylactic and therapeutic trials were instituted in.…”

The Emergent Field of Medical Mineralogy and Geochemistry

“…More than six decades ago, V.M. Goldschmidt, the father of Geochemistry, contributed to a study of the effect of olivine on the lungs of rats (King et al 1945). This study, led by Early Judson King, a prominent pathologist, was one of a series of studies directed at understanding silicosis in foundry workers.…”