The effect of olive oil on prevention of striae gravidarum: A randomized controlled clinical trial

Striae gravidarum (SG), or stretch marks developing during pregnancy, affect up to 90% of women. While not medically dangerous, SG can be disfiguring, causing emotional and psychological distress. However, studies specifically addressing the prevention of SG, especially during pregnancy, are sparse. Furthermore, the molecular pathogenesis of SG is unclear and may differ from that of striae from other causes. Considering these factors, we review topical modalities that have been used specifically for preventing SG during pregnancy. We identify two major strategies (end points) addressed by these modalities, namely (i) preventing the de novo development of SG and (ii) reducing the severity of SG that have recently developed. We also identify risk factors for the development of SG and suggest that pregnant women with these risk factors are an appropriate target population for prevention. In reviewing the literature, we find that there is limited evidence that centella, and possibly massage with bitter almond oil, may prevent SG and/or reduce their severity. There is weak evidence that hyaluronic acid prevents SG. Tretinoin holds promise for reducing the severity of new-onset SG, but its use is limited by its pregnancy category. Finally, cocoa butter and olive oil are not effective for preventing SG or reducing the severity of lesions. We conclude that reliable methods for preventing SG are scarce. Furthermore, available topical modalities generally lack strong evidence from rigorous, well-designed, randomized controlled trials with ample numbers of subjects. Thus, further research is necessary to elucidate SG pathogenesis, which may lead to effective prevention modalities.

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“…The use of olive oil for preventing SG is popular. Olive oil is rich in vitamin E and has emollient properties …”

Section: Methodsmentioning

confidence: 99%

“…In the second phase of the same randomized controlled trial, Soltanipoor et al . followed 100 nulliparous pregnant women, who applied either nothing or 1 ml of olive oil to the abdomen without massage twice daily from 18–20 weeks' gestation until delivery . This intervention did not reduce the incidence or severity of SG.…”

Section: Methodsmentioning

confidence: 99%

Stretch marks during pregnancy: a review of topical prevention

Korgavkar

Wang

2015

Br J Dermatol

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“…Significantly reduce the incidence and the severity of Striae gravidarum (SG). (Soltanipoor et al, 2012) In vitro release rates of Imiquimod were significantly faster than other products. (Harrison et al, 2009) Fluorouracil Extending treatment for up to 4 weeks will further improve actinic keratoses (AKs) lesion clearance rates.…”

Section: Olive Oilmentioning

confidence: 98%

Comprehensive review on additives of topical dosage forms for drug delivery

2014

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Skin is the largest organ of the human body and plays the most important role in protecting against pathogen and foreign matter. Three important modes such as topical, regional and transdermal are widely used for delivery of various dosage forms. Among these modes, the topical dosage forms are preferred because it provides local therapeutic activity when applied to the skin or mucous membranes. Additives or pharmaceutical excipients (non-drug component of dosage form) are used as inactive ingredients in dosage form or tools for structuring dosage forms. The main use of topical dosage form additives are controling the extent of absorption, maintaining the viscosity, improving the stability as well as organoleptic property and increasing the bulk of the formulation. The overall goal of this article is to provide the clinician with information related to the topical dosage form additives and their current major applications against various diseases.

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“…The frequency of striae with severe clinical manifestation was lower in the group of patients who used olive oil. However, the differences were not statistically significant [46].…”

Section: ключевые слова: стрии кожи этиопатогенез местное лечениеmentioning

confidence: 82%

Linear skin atrophy: current information and modern approaches to the external therapy

Leonidovich¹,

Sergeevich²,

Sergeevna³

2018

Medical news of the North Caucasus

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S tretch marks are manifestations of epidermal atrophy and result from tissue damage due to excessive tension [1, 2]. Stretch marks are one of the most common skin lesions for both women and men. The most frequent places of their locations are the abdomen, buttocks, thighs, chest, sleep, armpits and groin. Striae are divided according to the type and etiology on atrophic, stretch marks be-belt, linear stretch marks, red stretch marks, white striae, striae black and dark blue [3, 4]. Blue and black stretch marks are less common than other clinical types of stretch marks, especially among patients with dark skin phototypes due to the increasing saturation of melanin and in the foci [5, 6]. Due to its location in a particular anatomical region for stretch marks is characterized by the following pattern. Pragnacy stretch marks are predominantly localised in the abdominal area and on the breast; the adolescent stretch marks are localised on the thighs and in the lumbosacral region; nonpregnant young women get stretch marks mainly in the chest area and hips [5, 7, 8]. Most often striae are perpendicular to the lines of Langer, in directions with a minimum capacity of the skin to stretching [1, 2]. Striae represent linear atrophic scars, able despite the small area and, most often, the localization at closed clothing parts of the body, cause significant psychological difficulties and lower quality of life due to aesthetic concerns, and because of such subjective symptoms as itching [5, 9, 10, 11]. Thus, cross-sectional study of quality of life of Japanese pregnant women with striae showed that overall quality of life was not significantly different between women with stretch marks, and not having such. Howev

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The effect of olive oil on prevention of striae gravidarum: A randomized controlled clinical trial

Cited by 27 publications

References 5 publications

Stretch marks during pregnancy: a review of topical prevention

Stretch marks during pregnancy: a review of topical prevention

Comprehensive review on additives of topical dosage forms for drug delivery

Linear skin atrophy: current information and modern approaches to the external therapy

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