The Effect of Oligoclonal Bands in Patients with Multiple Sclerosis

Tutar, Nurhan Kaya; Söylemez, Elif; Ömerhoca, Sami; İçen, Nilüfer Kale

doi:10.4274/tnd.2022.72558

Cited by 1 publication

(4 citation statements)

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“…The majority (81.3%) of patients who had lesions in the spinal cord were OCB positive, meaning that spinal cord lesions were more frequently found in OCB positive patients. This correlates with the results of a study that found an association between OCB positivity and the presence of lesions in the lower cervical spinal cord segments [ 22 ]. Other studies on MS lesions and OCBs found no significant relation between spinal cord lesions and OCB positivity [ 28 , 29 ].…”

Section: Discussionsupporting

confidence: 91%

“…However, this study found no relation between the OCB positivity status and the age of symptom onset. The same results could be confirmed by the study performed in Turkey [ 22 ]. On the other hand, studies in Sweden and China have found that the age at the time of the first symptoms was earlier in OCB positive patients [ 23 , 24 ].…”

Section: Discussionsupporting

confidence: 81%

“…No statistically significant relation was found between OCB status and sex. Turkish, Norwegian and Chinese studies also reported the same result [ 22 , 24 , 25 ]. However, one Swedish study showed a higher prevalence of males in the OCB negative group [ 23 ].…”

Section: Discussionsupporting

confidence: 60%

“…An association with the course of the disease could not be analyzed, because only 10 out of 200 patients included in the study had PPMS or SPMS course. Other studies did not find a significant relation between OCB positivity status and the course of the disease [ 22 , 24 ], although some researchers report that OCB positivity is associated with primary progressive MS [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Oligoclonal Band Status and Features of Radiological and Clinical Findings in Patients with Multiple Sclerosis in Lithuania

Aleksandravičiūtė,

Stankevičiūtė,

Balnytė

et al. 2023

Medicina

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Background and Objectives: Multiple sclerosis (MS) is a widely spread and debilitating disease with 2.8 million people worldwide currently affected. However, the exact pathogenesis of the disease and its progression remains incompletely understood. According to the revised McDonald criteria, cerebrospinal fluid oligoclonal bands (CSF OCBs) magnetic resonance imaging (MRI) results, in conjunction with clinical presentation, remain the gold standard of MS diagnostics. Therefore, this study aims to evaluate the association between CSF OCB status and features of radiological and clinical findings in patients with multiple sclerosis in Lithuania. Materials and Methods: The selection of 200 MS patients was performed in order to find associations between CSF OCB status, MRI data and various disease features. The data were acquired from outpatient records and a retrospective analysis was performed. Results: OCB positive patients were diagnosed with MS earlier and had spinal cord lesions more frequently than OCB negative patients. Patients with lesions in the corpus callosum had a greater increase in the Expanded Disability Status Scale (EDSS) score between their first and last visit. Patients with brainstem lesions had higher EDSS scores during their first and last visit. Even so, the progression of the EDSS score was not greater. The time between the first symptoms and diagnosis was shorter for patients who had juxtacortical lesions than patients who did not. Conclusions: CSF OCBs and MRI data remain irreplaceable tools when diagnosing multiple sclerosis as well as prognosing the development of the disease and disability.

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Section: Discussionsupporting

confidence: 91%