The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions

Jumaa, Muhannad; Müller, Bernd W.

doi:10.1016/s0378-5173(97)00369-4

Cited by 122 publications

(61 citation statements)

References 13 publications

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“…For parenteral emulsions, the droplet size and size distribution are critical physicochemical parameters regarding patient safety because larger particles may cause embolism [2,6,15]. The mean droplet size of commercial parenteral fat emulsions is usually between 100 and 500 nm and it is generally required to be smaller than 1 µm [14], while the PDI, representing the size distribution width lower than 0.25 represents the acceptable value [16].…”

Section: Resultsmentioning

confidence: 99%

“…In the present study, the PCS particle size analysis (Table 3) confirmed that the mean droplet size (Z-Ave) of all prepared nanoemulsions was in nanometer range (172-208 nm), with a relatively narrow particle size distribution (PDI below 0.15), suggesting that developed nanoemulsions were suitable for parenteral use. Beside the droplet size, ZP is another important characteristic of the nanoemulsions and an indicator of the nanoemulsion stability [6,15]. Absolute ZP values greater than 30 mV point to good stability, while above 60 mV to the excellent one [16].…”

Section: Resultsmentioning

confidence: 99%

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A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

Cekić¹,

Đorđević²,

Savić³

et al. 2015

Savr tehnol

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Using the experimental design methodology, we have developed and characterized nanoemulsions for a parenteral delivery using diazepam as a model drug. The formulations containing 20 or 30% (w/w) of medium chain triglycerides or the mixture of medium chain triglycerides and soybean oil as the oil phase, soybean lecithin and polysorbate 80 as emulsifiers, and a phosphate buffer solution as the aqueous phase were prepared by cold high pressure homogenization. The obtained nanoemulsions were evaluated in terms of droplet size, size distribution, surface charge, drug-vehicle interactions and physical stability. To evaluate the effects of the oil phase type, oil content and drug presence, as well as their interactions on critical quality attributes of nanoemulsions, a three-factor two-level full factorial design was applied. After the preparation, all nanoemulsions revealed small spherical droplets in the range 170-210 nm, with the narrow droplet size distribution (< 0.15) and the surface charge about -60 mV. The experimental design results indicated that not only factors alone (oil type, oil content, presence of drug), but their interactions also had a significant effect on the nanoemulsion droplet size, polydispersity index, and zeta potential. During two months of storage at 25 °C, all nanoemulsions formulated with the medium chain triglycerides-soybean oil mixture (4:1, w/w) remained physically stable, without considerable changes in monitored parameters. Physicochemical characteristics and stability of these nanoemulsions demonstrated their suitability for parenteral drug delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

Cekić¹,

Đorđević²,

Savić³

et al. 2015

Savr tehnol

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show abstract

“…Recently, there has been a surge in the exploration of nanoemulsions for transdermal delivery (6)(7)(8). They are also being investigated ardently for potential applications in ocular (9,10), pulmonary (11), nasal (12,13), vaginal (14,15), and parenteral drug delivery (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion Components Screening and Selection: a Technical Note

et al. 2009

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“…Therefore, the high-pressure homogenisation technique was successfully adapted. 5) This method is mainly used for the production of microemulsions [6][7][8] and liposomes, 9,10) but there is only a limited number of studies concerning polymeric nanoparticle preparations. [11][12][13] The particle size is, however, an important parameter codetermining the particle distribution and drug release.…”

mentioning

confidence: 99%

“…5) This method is mainly used for the production of microemulsions [6][7][8] and liposomes, 9,10) but there is only a limited number of studies concerning polymeric nanoparticle preparations.…”

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confidence: 99%

Influence of the Homogenisation Procedure on the Physicochemical Properties of PLGA Nanoparticles

Vandervoort

Yoncheva

Ludwig

2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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One of the most popular techniques for the preparation of PLGA nanoparticles is emulsification solvent evaporation and its modifications such as the use of a double emulsion for the encapsulation of water soluble drugs. 1,2) In the current study, a homogenisation step was added to the preparation procedure. The effect of the stirring speed used during emulsification on the PLGA particle properties has been extensively examined.3,4) However, high stirring speed and even sonication are often not sufficient to achieve a small particle size and/or a narrow particle size distribution. Therefore, the high-pressure homogenisation technique was successfully adapted.5) This method is mainly used for the production of microemulsions [6][7][8] and liposomes, 9,10) but there is only a limited number of studies concerning polymeric nanoparticle preparations. 11-13)The particle size is, however, an important parameter codetermining the particle distribution and drug release. More specifically for ophthalmic use, it has been observed that large particles may irritate the eye. Consequently, smaller particles are preferred for ophthalmic delivery systems. 14)Additionally, Calvo et al. have reported that poly(e-caprolactone) nanoparticles (0.20-0.25 mm) improve ocular bioavailibility of indomethacin rather than poly(e-caprolactone) microparticles (6 mm).15) Thus, one of the most important characteristics of nanoparticles is their size.The present study aimed to evaluate the feasibility of homogenisation as a tool to adapt the properties of pilocarpine HCl-loaded PLGA nanoparticles. The influence of the homogenisation procedure on the size, the zeta potential value, drug encapsulation and drug release of the particles prepared was studied.The homogenisation parameters studied were the pressure applied, as well as the number of cycles.PLGA particles were prepared using three different stabilisers: polyvinylalcohol (PVA), carbomer (Carbopol 980 NF) and poloxamer (Lutrol F-68). PVA is the reference stabilising agent for the emulsification-solvent evaporation method.3) The feasibility of the use of Carbopol and poloxamer has been demonstrated in earlier work.16) Apart from these three stabilisers, mixtures of PVA and poloxamer as well as mixtures of PVA and Carbopol were also employed.The ocular bioavailibility can be improved using mucoadhesive particulate drug delivery systems.17) Various methods have been developed to evaluate the mucoadhesion of nanoparticulate drug delivery systems. Determination of the detachment force for microspheres from pig intestinal mucosa 18) or from mucus model gel 19) was proposed. Another method was to evaluate the amount of attached or non-adherent nanoparticles after placing on the rat intestinal mucosa. 20)Some authors investigated the behaviour of mucin/bioadhesive polymer dispersions by rheology 21,22) or by turbidimetric measurements.23) Thus, the interaction between mucin and mucoadhesive products caused changes in the viscosity or turbidity of the dispersions. Since these techniques are easily ...

show abstract

The effect of oil components and homogenization conditions on the physicochemical properties and stability of parenteral fat emulsions

Cited by 122 publications

References 13 publications

A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

A full factorial design in the formulation of diazepam parenteral nanoemulsions: Physicochemical characterization and stability evaluation

Nanoemulsion Components Screening and Selection: a Technical Note

Influence of the Homogenisation Procedure on the Physicochemical Properties of PLGA Nanoparticles

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