The Effect of Occupational Lead Exposure on Blood Levels of Zinc, Iron, Copper, Selenium and Related Proteins

Kasperczyk, Aleksandra; Prokopowicz, Adam; Dobrakowski, Michał; Pawlas, Natalia; Kasperczyk, Sławomir

doi:10.1007/s12011-012-9490-x

Cited by 52 publications

(45 citation statements)

References 47 publications

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“…In this study serum lead (Pb) level was higher in the traffic policemen than the control. Evidence from previous studies also supports this observation [13][14][15] . But some studies do not support this 16 .The correlation analysis in this study between FEV 1 , FVC, FEV1/FVC ratio and serum lead level in TP showed negative relationship though statistically was not significant.…”

Section: Discussionsupporting

confidence: 82%

Relationship between FVC, FEV1, FEV1/FVC% and serum lead level of the traffic policemen in Dhaka city.

Ahmed

Akter

Ahmed³

et al. 2018

J Bangladesh Soc Physiol

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Background: Air pollution is increasing day by day in Dhaka city due to automobile exhaust emitted from huge number of vehicles. Automobile pollutants inhalation would increase the blood lead level which may be associated with acute and chronic respiratory disease.Objective: To observe the relationship of FVC, FEV1, FEV1/FVC% with serum lead level in traffic policemen in Dhaka city.Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College (DMC),Dhaka from July 2014 to June 2015. The study group enrolled 50 apparently healthy traffic policemen aged 25 to 45 years engaged in traffic control at different traffic junctions of Dhaka city and the control group consisted of apparently healthy subjects working in bank and different offices in Dhaka city with similar BMI and age to traffic police subjects. FVC, FEV1 and FEV1/FVC% of all the subjects were measured by digital spirometer and serum lead level was estimated by Flame Atomic Absorption Spectrophotometry. Statistical analysis was done by Pearson’s correlation coefficient test. Independent sample ‘t’ test.Results: In this study, serum lead level was found significantly higher in the traffic policemen than the control group. FVC, FEV1 and FEV1/FVC showed negative correlation with serum Lead level but it was not statistically significant.Conclusion: From the result of this study, it can be concluded that traffic policemen may be in greater exposure to severe air pollution with higher lead content in Dhaka city and it may affect their lung function.J Bangladesh Soc Physiol. 2018, June; 13(1): 13-16

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Section: Discussionsupporting

confidence: 82%

Relationship between FVC, FEV1, FEV1/FVC% and serum lead level of the traffic policemen in Dhaka city.

Ahmed

Akter

Ahmed³

et al. 2018

J Bangladesh Soc Physiol

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“…Lead can not only generate reactive oxygen species (ROS), but also be able to deplete antioxidant reserves (6). Furthermore, elevated levels of ALA, characteristic of plumbism, generate hydrogen peroxide and superoxide radicals.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Dobrakowski¹,

Zalejska–Fiolka²,

Wielkoszyński³

et al. 2014

Med Pr

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Background: The role of non-enzymatic antioxidants, such as uric acid, albumin, bilirubin, and α-tocopherol, in lead poisoning remains unclear. Therefore, the aim of the study was to explore the association between occupational exposure to lead and nonenzymatic antioxidant concentrations in serum and plasma. Material and Methods: The study population consisted of 278 healthy male employees of lead-zinc plants, with 129 workers classified as having low lead exposure (blood lead level -PbB = 20-39.9 μg/dl) and 149 workers classified as having high lead exposure (PbB = 40-59.8 μg/dl). The control group was composed of 73 healthy male administrative workers. No one from this group had blood lead level or zinc protoporphyrin (ZPP) level greater than normal levels, being 10 μg/dl and 2.5 μg/g of hemoglobin, respectively. In addition to the levels of PbB and ZPP, serum levels of uric acid (UA), albumin, thiol groups of albumin, and bilirubin were determined. The ferric reducing ability of plasma (FRAP) and the plasma level of α-tocopherol were also evaluated. Results: Lead exposure indices were significantly elevated in the examined subgroups as compared with the controls. Serum uric acid levels were significantly elevated in both subgroups, particularly in the group with high exposure. Serum bilirubin concentration was significantly elevated in the group with high exposure compared with the control group, while in the group with low exposure, it showed only a non-significant trend towards an increase. In contrast, ferric-reducing ability of plasma was not significantly greater in the examined subgroups as compared with the control group. Nevertheless, levels of albumin, thiol groups of albumin, and α-tocopherol levels were significantly decreased in the exposed subgroups compared with the control group. Conclusions: Occupational exposure to lead interferes with the blood non-enzymatic antioxidant system. Med Pr 2014;65(4): [443][444][445][446][447][448][449][450][451]

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“…Altered RBC counts and eryptosis are common in occupationally Pb-exposed workers [33][34][35]. Intriguingly, due to its adverse effects on RBCs, Pb exposure has recently been considered a pathogenetic factor for chronic cardiovascular and renal diseases [36,37].…”

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confidence: 99%

Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study

Corsetti

Romano

Stacchiotti

et al. 2016

Biol Trace Elem Res

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Lead (Pb) is an environmental oncogenic metal that induces immunotoxicity and anaemia. Emerging evidence has linked Pb toxicity with endoplasmic reticulum-driven apoptosis and autophagy. Glucose-regulated protein of 78 kDa (Grp78 or binding immunoglobulin protein (BiP)), a master endoplasmic reticulum chaperone, drives macrophage activation and regulates protein folding and calcium flux in response to heavy metals.

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The Effect of Occupational Lead Exposure on Blood Levels of Zinc, Iron, Copper, Selenium and Related Proteins

Cited by 52 publications

References 47 publications

Relationship between FVC, FEV1, FEV1/FVC% and serum lead level of the traffic policemen in Dhaka city.

Relationship between FVC, FEV1, FEV1/FVC% and serum lead level of the traffic policemen in Dhaka city.

The Effect of Occupational Exposure to Lead on the Non-Enzymatic Antioxidant System

Endoplasmic Reticulum Stress and Apoptosis Triggered by Sub-Chronic Lead Exposure in Mice Spleen: a Histopathological Study

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