The effect of occupational exposure to petrol on pulmonary function parameters: a review and meta-analysis

Moghadam, Somayeh Rahimi; Afshari, Mahdi; Moosazadeh, Mahmood; Khanjani, Narges; Ganjali, Ali

doi:10.1515/reveh-2019-0048

Cited by 6 publications

(8 citation statements)

References 36 publications

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“…Therefore, it can increase the prevalence of respiratory complications among gas station workers. Also, in a meta-analysis conducted in 2019, it was determined that occupational exposure to gasoline fumes is a risk factor for lung function and the prevalence of respiratory complications [33]. These results are consistent with our study.…”

Section: Resultssupporting

confidence: 92%

“…These findings are consistent with the study conducted in Nigeria in 2016 [14]. Body mass index (BMI) is one of the most important factors affecting pollutant absorption because lipophilic volatile pollutants produced in gas stations are absorbed proportionally to both adipose mass and BMI [15]. The mean BMI of the participants was in the range of 24.45 kg/m 2 , which was not consistent with the study conducted in Egypt in 2023 [16].…”

Section: Resultssupporting

confidence: 59%

“…Because these tests identify more sensitive employees before they experience permanent and chronic problems. This study also highlighted the use of safety gear and adherence to safety regulations at fueling stops [15]. In this study, we measured the variables of cough, chest tightness, coughing attacks and airway mucus, shortness of breath, and wheezing in situations that patients can experience.…”

Section: Resultsmentioning

confidence: 99%

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Untitled

2023

J. Med. Chem. Sci.

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Objectives: Gas station workers who are continuously exposed to gasoline/diesel smoke, are at high risk of causing respiratory problems. This study was conducted to determine the prevalence of respiratory disorders in gas station workers in Erbil City, Iraq. Methods: All (146) of the petroleum outlets in Erbil City overseen by the Ministry of Natural Resources were the subject of this cross-sectional descriptive study. A researcher-made checklist with four sections-Sociodemographic characteristics, a checklist of respiratory disorders' signs and symptoms to evaluate the frequency of respiratory symptoms, auscultation of the chest to evaluate any abnormal breath sounds, and peak flow meter to evaluate peak expiratory flow rate-was used to gather data. A p-value of ≤ 0.05 was considered statistically significant. Result: Most of the employees (54.1%) were between the ages of 23 and 27 and were unmarried (65.5%). The most frequent symptoms were listed in the symptoms part as a common cough, typically clear-out sputum when awake, loss of breath when walking quickly on a level surface or when ascending a moderate incline, and a wheezing sound in your chest. Wheezing was detected in 189 of the employees (37.7%), while rhonchi was detected in 71 (14.2%). Conclusion: Gas station workers in Erbil are exposed to gasoline and vapors produced while filling cars and smoke from cars. It was also proven that workers used poor protective measures despite their knowledge of the adverse health effects of gasoline.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 59%

Section: Resultsmentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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“…Gasoline is the most consumed product of crude oil refining, which contains at least 150 hydrocarbons, including alkanes (60-70%), aromatics (25-30%) and alkenes (6-9%). Gasoline vapors (GV) have been linked to various pathologies, such as lung disorders, hematotoxicity, and encephalopathies [1][2][3][4]. The results of many studies have also shown that employees of gas stations and refineries who are chronically exposed to GV are at high risk of developing lung, kidney, and bladder cancers [5][6][7], as well as hematological malignancies [8].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Dietary Vitamin D3, Turmeric Powder and Their Combination Against Gasoline Intoxication in Rats

Yestemirova,

Yessimsiitova,

Danilenko

2023

Preprint

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Inhalation of gasoline vapors (GV) is associated with developing various pathologies. Particularly, oil refinery and gas station workers are at greater risk of developing lung cancer, kidney cancer, bladder cancer, and hematological disorders, including acute myeloid leukemia. Therefore, preventing the harmful effects of GV and alleviating their consequences appear to be an important and timely issue. In this study, we investigated the potential of vitamin D3, turmeric powder and their combination to ameliorate the toxicity of gasoline fumes in rats. Separate groups of animals fed with a standard rodent diet, with or without supplementation of vitamin D3 (750 IU/kg of body weight) and/or turmeric powder (0.5%, w/w, in food), were untreated or treated with GV (11.5±1.3 cm3/h/m3/day) for 30, 60 or 90 days. Changes in the body weight were monitored weekly. Histological, biochemical, and hematological parameters were determined at the end of each treatment period. While exposure of rats to GV resulted in a time-dependent reduction in body weight, supplementation with vitamin D3, but not with turmeric root powder or their combination, partially prevented weight loss. Macroscopical and histological analyses showed pronounced time-dependent changes in the organs and tissues of GV-treated rats. These included alveolar wall collapse in the lungs, destruction of the lobular structure and hepato-cytolysis in the liver, shrinkage and fragmentation of glomeruli in the kidneys, and disorganization of the lymphoid follicles in the spleen. However, co-treatment with the nutritional supplements tested, especially vitamin D3, noticeably alleviated the above conditions. This was accompanied by a significant improvement in blood chemistry and hematological parameters. Collectively, our results demonstrate that the harmful effects of environmental exposure to GV can be reduced upon supplementation of vitamin D3. The fact that the protective activity of vitamin D3 alone was higher than that of turmeric root powder or the combined treatment suggests that combinations of these supplements may not always be more beneficial than each agent applied separately.

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“…Biological monitoring and risk assessment associated with exposure to chemical toxicants at the work place can be evaluated by measuring indices of organ and systemic functions in the exposed populations. An inverse relationship has been reported between lung function indices and duration of exposure to gasoline fumes in occupationally exposed individuals (Moghadam, et al, 2019). Higher levels of biomarker of oxidative DNA damage (8-OHdG) have been reported in gasoline station attendants compared to controls (Fenga, et al, 2017), while elevation of lipid peroxidation products and oxidative stress have been demonstrated in petroleum attendants (Leong,2021).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of oxidative stress, oxidative dna damage and lowered pefr in gasoline station attendants in calabar metropolis

Eworo¹,

A²,

Thomas³

et al. 2023

Glo Jnl Pure Appl Sci

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Exposure to gasoline fumes through inhalation or accidental ingestion has been associated with chronic inflammatory reactions leading to oxidative stress, oxidative DNA damage and increased risk of chronic lung conditions and cancer. This study assessed the peak expiratory flow rate (PEFR) and biomarkers of oxidative stress (total antioxidant capacity (TAC), total plasma peroxides (TPP), oxidative stress index (OSI)), oxidative DNA damage (8-hydroxy-2-deoxyguanosine (8-OHdG)), 1-hydroxypyrene and urine creatinine in Gasoline Station Attendants. A total of 100 consenting adults, aged 18-60 years, comprising 50 gasoline station attendants and 50 non-gasoline station attendants (controls) were enrolled into this comparative cross-sectional study. The PEFR was determined using the peak flow meter, TAC, TPP and creatinine by colorimetry, 8-OHdG by enzyme linked immunosorbent assay (ELISA), 1-hydroxypyrene (1-HOP) by high performance liquid chromatography and OSI by calculation. Data was analysed using unpaired Student t-test and Pearson's correlation analysis at p<0.05. The body mass index, TPP, OSI and 8-OHdG levels were significantly higher and TAC and PEFR lower in gasoline pump attendants compared to the control groups (p<0.05). Positive correlations were observed between TPP and years at work (r=0.638, p=0.000), between TPP and OSI (r=0.282, p=0.047) and negative correlation between TAC and OSI (r=-0.555, p=0.000) only in gasoline station attendants. Exposure to gasoline is associated with increased lipid peroxidation and oxidative DNA damage, reduced lung function and depletion of antioxidants which may result in oxidative stress and increased risk for the development of chronic lung conditions in gasoline station attendants.

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The effect of occupational exposure to petrol on pulmonary function parameters: a review and meta-analysis

Cited by 6 publications

References 36 publications

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Protective Effects of Dietary Vitamin D3, Turmeric Powder and Their Combination Against Gasoline Intoxication in Rats

Enhancement of oxidative stress, oxidative dna damage and lowered pefr in gasoline station attendants in calabar metropolis

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