The effect of occupational exposure to benzo[a]pyrene on neurobehavioral function in coke oven workers

Qiu, Chongying; Peng, Bin; Cheng, Shuqun; Xia, Yinyin; Tu, Baijie

doi:10.1002/ajim.22119

Cited by 27 publications

(13 citation statements)

References 48 publications

(56 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Findings of another study monitored digital span and order digital span scores showed that memory and learning abilities were considerably reduced in coke oven workers [21]. Also the performances on correct pursuit aiming, simple reaction time, and error pursuit aiming have been shown to decrease in coke oven workers exposed to airborne enzo [α] pyree [22]. It seems that not only many other factors involved in workers' lifestyles which are engaged in neurocognitive impairment, but also unknown roles of the oxidative stress with a highlighted background in damaging different parts of nervous system should not be ignored, particularly in long term exposures.…”

Section: Discussionmentioning

confidence: 99%

A Survey on Neuropsychological State, Oxidative Stress and Hematological Parameters in Coke Oven Workers

Salehiforouz¹,

Malekirad²,

Abdollahi³

et al. 2014

Health

View full text Add to dashboard Cite

Coke oven factories are one of the main emitting sources of polycyclic aromatic hydrocarbons (PAH)s which have been identified as highly carcinogenic chemicals by IARC. Induction of oxidative stress and following disrupting pathways has been repeatedly reported in subjects exposed to PAHs. This study was performed to monitor the oxidative stress markers, hematological and biochemical parameters, and psychological states in coke oven workers. 100 male subjects were included in this comparative cross-sectional study. At first 50 male workers who were 22-63 and worked in the steel factory located in SouthEast of Iran were contained. Control subjects were chosen from Esfahan, in the factory's neighborhood, consisting of 50 office workers without any background of occupational exposure to metals. The blood levels of hematological factors and oxidative stress were measured. In order to compare data, two-sample t test was applied. In order to measure the correlation between variables, Pearson correlation coefficient was applied. The mean level of total antioxidant capacity, hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and hematocrit were significantly lower in the workers in association with increased lipid per oxidation (LPO). A positive correlation existed between work history, hyper thyroids (r 2 = 0.288, p = 0.01), and endocrine disorders (r 2 = 0.309, p = 0.028). Occupational exposure of coke oven workers to PAHs can induce oxidative stress and consequent metabolic and neuropsychological disorders. When workers take daily shower and use protective tools, absorption of toxic elements would decrease so that reaching them to the body can be suitably limited.

show abstract

Section: Discussionmentioning

confidence: 99%

A Survey on Neuropsychological State, Oxidative Stress and Hematological Parameters in Coke Oven Workers

Salehiforouz¹,

Malekirad²,

Abdollahi³

et al. 2014

Health

View full text Add to dashboard Cite

show abstract

“…As compared to PAH mixtures, B[a]P confers a higher health risk in terms of immunosuppression, carcinogenicity, teratogenicity, and mutagenicity. It is well-known that B [a]P plays a critical role in the initiation of cancers in lung at its first proximity, and inducing cell proliferation is one of the early occurrence prior to cell malignant transformation (Qiu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Alterations of DNA methylation andmRNAlevels ofCYP1A1,GSTP1,andGSTM1in human bronchial epithelial cells induced by benzo[a]pyrene

Liu

Hao

et al. 2022

Toxicol Ind Health

View full text Add to dashboard Cite

Benzo[a]pyrene (B[a]P) is a known human carcinogen and plays a major function in the initiation of lung cancer at its first proximity. However, the underlying molecular mechanisms are less well understood. In this study, we investigated the impact of B[a]P treatment on the DNA methylation and mRNA levels of CYP1A1, GSTP1, and GSTM1 in human bronchial epithelial cells (16HBEs), and provide scientific evidence for the mechanism study on the carcinogenesis of B[a]P. We treated 16HBEs with DMSO or concentrations of B[a]P at 1, 2, and 5 mmol/L for 24 h, observed the morphological changes, determined the cell viability, DNA methylation, and mRNA levels of CYP1A1, GSTP1, and GSTM1. Compared to the DMSO controls, B[a]P treatment had significantly increased the neoplastic cell number and cell viability in 16HBEs at all three doses (1, 2, and 5 mmol/L), and had significantly reduced the CYP1A1 and GSTP1 DNA promoter methylation levels. Following B[a]P treatment, the GSTM1 promoter methylation level in 16HBEs was profoundly reduced at low dose group compared to the DMSO controls, yet it was significantly increased at both middle and high dose groups. The mRNA levels of CYP1A1, GSTP1, and GSTM1 were significantly decreased in 16HBEs following B[a]P treatment at all three doses. The findings demonstrate that B[a]P promoted cell proliferation in 16HBEs, which was possibly related to the altered DNA methylations and the inhibited mRNA levels in CYP1A1, GSTP1, and GSTM1.

show abstract

“…Similarly, coke-oven workers in China had lower learning-ability and memorization-test performance that correlated with levels of the PAH 1-OH-pyrene in urine [12]. Mechanistically, exposure to B[a]P was linked to memory and learning disabilities in these coke-oven workers by a reduction in choline, monoamine and amino acid neurotransmitter levels [12,13]. Occupational exposure is not the only concern, however.…”

Section: Introductionmentioning

confidence: 99%

Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study

Cherif

Cao-Lei

Farinelle

et al. 2021

Toxics

View full text Add to dashboard Cite

The potent neurotoxicity of benzo[a]pyrene (B[a]P) has been suggested to be a susceptibility factor accelerating the onset of brain tumours and the emergence of neurobehavioural disturbances. B[a]P has been shown to be neurotoxic, acting directly on both the central and peripheral nervous systems, as well as indirectly via peripheral organs like liver and gut. By using a realistic B[a]P exposure scenario (0.02–200 mg/kg/day, 10 days) in mice, we elucidated brain-specific B[a]P metabolism and at identified hydroxylated B[a]P metabolites in serum which could be used as markers of cognitive impairment. Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself. At the same doses, mice exhibited a reduction in anxiety in both the elevated plus maze and the hole board apparatus. Concomitantly, B[a]P triggered dose-dependent changes in Nmda subunit expression (Nr1 and Nr2a/Nr2b) in areas involved in cognition. We detected 9-OH-B[a]P and 7,8-diol-B[a]P in serum at the level for which cognitive impairment was observed. We suggest that these metabolites may, in the future be exploited as potent biomarkers of B[a]P-induced cognitive impairments.

show abstract

The effect of occupational exposure to benzo[a]pyrene on neurobehavioral function in coke oven workers

Abstract: Occupational exposure to B[a]P is associated with neurobehavioral function impairment in coke oven workers.

Cited by 27 publications

References 48 publications

A Survey on Neuropsychological State, Oxidative Stress and Hematological Parameters in Coke Oven Workers

A Survey on Neuropsychological State, Oxidative Stress and Hematological Parameters in Coke Oven Workers

Alterations of DNA methylation andmRNAlevels ofCYP1A1,GSTP1,andGSTM1in human bronchial epithelial cells induced by benzo[a]pyrene

Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study

Contact Info

Product

Resources

About