The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin

Suberu, John O.; Yamin, Peyman; Leonhard, Kai; Song, Lijiang; Chemat, Smaïn; Sullivan, Neil F.; Barker, Guy C.; Lapkin, Alexei

doi:10.1016/j.jbiotec.2013.11.024

Cited by 15 publications

(13 citation statements)

References 37 publications

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“…An integration of the crystallization step provides financial advantages, due to its low operation costs. By integrating the crystallization step into the downstream of artemisinin as a purification step, the composition of the feed solution is essential, because of the influences of side components on solubility and kinetics [15][16][17]26,32,42,43]. With the shift of the crystallization step to earlier stages, it becomes more affectable by the variability of the side component spectrum, which is a significant factor for plant-based material.…”

Section: Raw and Purified Materialsmentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

et al. 2018

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In this study, process integration for crystallization of a priori purified Artemisia annua L. is investigated. For this total process, the integration operation boundaries and behavior of the crystals are studied. This is performed focusing on a conceptual process design study for artemisinin, aiming towards the development of a crystallization step under given parameters by process integration. At first, different crystallization systems consisting of ethanol-water or acetone-water mixtures are compared. In subsequent steps, the metastable zone width and the behavior of the crystals regarding agglomeration and breakage are checked. Furthermore, the sensitivities of process variables based on several process parameters are investigated. Additionally, the final process integration of crystallization as a combined purification and isolation step is studied.

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Section: Raw and Purified Materialsmentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

et al. 2018

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“…Silica gel is reportedly being used in China, whereas a mixed system comprising activated carbon and Celite was described recently [19]. Upon contact of the raw extract with an adsorbent bed, waxes and other large molecules co-extracted along with artemisinin are preferentially removed by an adsorbent, leaving a cleaner extract from which higher purity raw artemisinin with higher crystallization yields are then obtained.…”

Section: Industrial Extraction Processesmentioning

confidence: 99%

“…The initial step of artemisinin recovery from the raw extract has been recently studied in detail for the cases of ethanol [26] and hexane/ethyl acetate extracts [19]. The initial step of artemisinin recovery from the raw extract has been recently studied in detail for the cases of ethanol [26] and hexane/ethyl acetate extracts [19].…”

Section: Hybrid Adsorption-crystallization Separationmentioning

confidence: 99%

Green Extraction of Artemisinin from Artemisia annua L

Lapkin

2015

Green Extraction of Natural Products

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“…Not only extraction and synthesis have been investigated; whole processes and value chains single unit operations in the downstream of artemisinin have been assessed [22]. Suberu et al identified co-metabolites in the plant extract that negatively affect the crystallization of artemisinin [23]. This investigation is very important to identify those compounds that must be removed by unit operations before crystallization.…”

mentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation

et al. 2018

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The article summarizes a systematic process design for the extraction and purification of artemisinin from annual mugwort (Artemisia annua L.). Artemisinin serves as an anti-malaria drug, therefore, resource-efficient and economic processes for its production are needed. The process design was based on lab-scale experiments and afterwards piloted on miniplant-scale at the institute. In this part of the article, a detailed economic feasibility studies including a reference process as a benchmark the lab-scale process and the pilot-scale process is given. Relevant differences between the different scales are discussed. The details of the respective unit operations (solid-liquid extraction, liquid-liquid extraction, chromatography and crystallization) are presented in dedicated articles. The study showed that even miniaturized lab-scale experiments are able to deliver data detailed enough for scale-up calculations on a theoretical basis. To our knowledge, a comparable systematic process design and piloting was never performed by academia before.

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The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin

Cited by 15 publications

References 37 publications

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

Green Extraction of Artemisinin from Artemisia annua L

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation

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