The Effect of Nrf2 on Diabetic Complications

Reis, Ângela Adamski da Silva; Santos, Rodrigo da Silva; Cruz, Aline Helenada Silva; Silva, Elisângela Gomes da; Cruz, Aparecido Divino da; Pedrino, Gustavo Rodrigues

doi:10.5772/66132

Cited by 7 publications

(7 citation statements)

References 38 publications

(91 reference statements)

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“…The activation of Nrf2 may aid in the prevention of diabetic nephropathy. Nrf2 departs from Keap1 and enters the nucleus, where it binds to genes that code for antioxidant enzymes [ 197 , 198 , 199 ]. The Nrf2 protein may be activated by various extracts and phytochemical substances found in herbs and vegetables.…”

Section: Different Therapeutic Targets Of Diabetes Treating With Herb...mentioning

confidence: 99%

“…Insulin is an anti-hyperglycemic hormone produced by beta cells in the pancreas that helps to keep blood glucose levels in check [ 197 ]. As a consequence of the destruction to the pancreatic beta cells, insulin shortage occurs, leading to hyperglycemia, which could be either T1DM or T2DM.…”

Section: Different Therapeutic Targets Of Diabetes Treating With Herb...mentioning

confidence: 99%

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The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

et al. 2022

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Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people’s lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity.

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Section: Different Therapeutic Targets Of Diabetes Treating With Herb...mentioning

confidence: 99%

Section: Different Therapeutic Targets Of Diabetes Treating With Herb...mentioning

confidence: 99%

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

et al. 2022

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“…Several mechanistic hypotheses have been proposed, including the direct scavenging of free radicals to reduce oxidative stress, the prevention of lipid peroxidation, and thus the suppression of signaling pathway leading to cell proliferation and apoptosis (Khoo et al, 2017). In the context of cardiovascular disease, the antioxidant activity of anthocyanins has been shown to block nitric oxide production and promote the activity of the transcription factor Nrf2, which in turn regulates the expression of multiple genes encoding proteins that protect against oxidative damage, such as heme oxygenase-1 (Reis et al, 2016). The systemic anti-inflammatory activity of anthocyanins may also reflect their ability to modulate the gut microbiome, increasing the prevalence of beneficial organisms such as bifidobacteria (Morais et al, 2016).…”

Section: Multifunctional Phytocomplexes From R4g Cells Are Promising mentioning

confidence: 99%

Red Carrot Cells Cultured in vitro Are Effective, Stable, and Safe Ingredients for Skin Care, Nutraceutical, and Food Applications

Bianconi

Ceriotti²,

Cuzzocrea

et al. 2020

Front. Bioeng. Biotechnol.

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Plant biomasses growing in bioreactor could be developed as production systems for cosmetic ingredients, nutraceuticals and food additives. We previously reported that the red carrot cell line R4G accumulates high levels of anthocyanins, which are potent antioxidants with multiple health-promoting properties. To investigate the industrial potential of this cell line in detail, we tested extract for antioxidant and anti-inflammatory activity in the mouse monocyte/macrophage cell-line J774A.1 and in reconstructed skin tissue models. We also compared the R4G extract to commercial carrot extracts in terms of stability and metabolomic profiles. We found that the R4G extract have potent antioxidant and anti-inflammatory activities, protecting mammalian cells from the oxidative stress triggered by exposure to bacterial lipopolysaccharides and H 2 O 2. The extract also inhibited the nuclear translocation of NF-κB in an epidermal skin model, and induced the expression of VEGF-A to promote the microcirculation in a dermal microtissue model. The anthocyanins extracted from R4G cells were significantly more stable than those found in natural red carrot extracts. Finally, we showed that R4G extract has similar metabolomic profile of natural extracts by using a combination of targeted and untargeted metabolomics analysis, demonstrating the safety of R4G carrot cells for applications in the nutraceutical and food/feed industries.

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“…Third, they have a lesser chance of receiving all the diagnostic and therapeutic measures than their diabetic male counterpart, even if it is well known that mortality after a first cardiovascular event is more elevated in diabetic women. Finally, anti-aggregating and hypotensive drugs seem to be less productive in diabetic women, while the side effects of hypoglycemic agents seem to be more frequent in females [4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Also, there are gender differences responsible for the development of T2D. Both cases lead to severe complications such as retinopathy, nephropathy, neuropathy, stroke, and diabetic foot ulcers [5]. The widely recognized association between type 2 diabetes and cardiovascular disease (CVD) has a different significance according to sex, being more assertive in diabetic women than men.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gender and Risk Factors in Complications of Type 2 Diabetic Mellitus among Patients Attending Diabetic Clinic in Mnazi Mmoja Hospital, Zanzibar

Okafor

Yusuf

Mahmoud

et al. 2021

JPRI

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Diabetes type 2 (T2D) had caused the loss of millions of lives all over the world. About 50% of the patients with T2D die because of cardiovascular disease (CVD), primarily myocardial infarction and stroke. Many of the leading risk factors for CVD coexist and act synergistically to increase cardiovascular events. The purpose of this descriptive cross-sectional study was to determine the prevalence, patterns, and certain predictive factors in the complications of T2D patients attending diabetic clinics at Mnazi Mmoja hospital. A total of 138 respondents made up of 58 females and 80 males within the age brackets of 30-40, 41-50, 51 – 60, and 61 above were recruited for this study. Data were analysed and interpreted based on certain predictive factors and variables, including smoking, alcohol, excessive salt intake, lipid intake, sedentary lifestyle, family history of diabetes, and hypertension, on how they relate to the development of complications of type 2 diabetes. Pearson Chi-Square test was used to compare the levels of significances. Probability values of less or equal to 0.05 were accepted to be significant. The combination of salt intake, sedentary lifestyle, family history of diabetes, and lipid intake was the commonest risk factor for developing complications of T2D. However, alcohol and cigarette smoking had the most negligible impact on developing complications in T2D. The result also shows the patients between the age bracket of 30 and 40 have more risk factors for developing complications. The result showed no gender difference in the number of risk factors. There was a statistically significant association between some of the risk factors (smoking, alcohol, sedentary lifestyle, and salt intake) and the gender of respondents (p<0.05). Males smoked (43.8%) and consumed alcohol (32.5%) than females, while females were prone to a sedentary lifestyle (63.8%) and consume salt (82.8%) than males. On the other hand, this research showed that the significant complication for both males and females are numbness, pain sensation, and dry skin (diabetic neuropathy). Gender and certain predictive risk factors like salt intake, sedentary lifestyle, and family history of diabetes, and lipid intake are fundamental parameters to be tackled to reduce the complications of type 2 diabetes mellitus. There is a greater need now for awareness of the risk factors through effective health promotion in Zanzibar. Also, secondary prevention through regular screening, early detection, and appropriate treatment of chronic complications could reduce the morbidity and mortality caused by diabetes mellitus.

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The Effect of Nrf2 on Diabetic Complications

Cited by 7 publications

References 38 publications

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

Red Carrot Cells Cultured in vitro Are Effective, Stable, and Safe Ingredients for Skin Care, Nutraceutical, and Food Applications

Effect of Gender and Risk Factors in Complications of Type 2 Diabetic Mellitus among Patients Attending Diabetic Clinic in Mnazi Mmoja Hospital, Zanzibar

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