2006
DOI: 10.1016/j.jacc.2006.05.049
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The Effect of Novel Cardiovascular Risk Factors on the Ethnic-Specific Odds for Peripheral Arterial Disease in the Multi-Ethnic Study of Atherosclerosis (MESA)

Abstract: Ethnic associations with PAD remained significant even after adjustment for traditional and novel risk factors. This suggests that unknown factors may account for the residual ethnic differences in PAD.

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Cited by 219 publications
(212 citation statements)
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“…4,5,28 Consistent with prior reports, differences in IL-6 production were evident between non-Hispanic Caucasians, Hispanics, and African Americans, with African Americans exhibiting the lowest IL-6 levels. 29 More critically, however, our study extends earlier findings by showing, for the first time, that using mentholated cigarettes may impose additional burdens on the body's regulation of inflammatory response among African Americans and Hispanics living with HIV. These increases in IL-6 parallel the CD4 and viral outcomes in those receiving HAART and, consequently, may help explain the findings from the FIRST multisite trial.…”
Section: Discussionsupporting
confidence: 83%
“…4,5,28 Consistent with prior reports, differences in IL-6 production were evident between non-Hispanic Caucasians, Hispanics, and African Americans, with African Americans exhibiting the lowest IL-6 levels. 29 More critically, however, our study extends earlier findings by showing, for the first time, that using mentholated cigarettes may impose additional burdens on the body's regulation of inflammatory response among African Americans and Hispanics living with HIV. These increases in IL-6 parallel the CD4 and viral outcomes in those receiving HAART and, consequently, may help explain the findings from the FIRST multisite trial.…”
Section: Discussionsupporting
confidence: 83%
“…It has been reported previously that the prevalence of peripheral arterial disease in the general population is higher among African Americans than Hispanics (13,39,40). Our study is the first to report the prevalence of measured peripheral arterial disease in a cohort of Hispanics with CKD not yet on dialysis.…”
Section: Discussionmentioning
confidence: 52%
“…To determine factors independently associated with clinical and subclinical measures of CVD, we fitted multivariate hierarchical logistic regression models that included (1) crude (unadjusted) measures, (2) demographic measures, and (3) clinical measures (see Table 4). These variables were chosen based on bivariate analyses and prior studies (5, [13][14][15][16][17][18]. The only variables with Ͼ3% missing values were proteinuria/24 h (6%), income (15%), and health insurance (12%); the latter two were not included in the regression models.…”
Section: Discussionmentioning
confidence: 99%
“…Diabetes has also been shown to be a risk factor for either a high or low ABI 31) . The effects of diabetes are complex, as this condition is associated with both atherosclerosis and MAC of the peripheral arteries.…”
Section: Discussionmentioning
confidence: 99%