The effect of Norplant  on glucose metabolism under hyperglycemic hyperinsulinemic conditions

Shamma, Fayek N.; Rossi, G.; Haj-Hassan, L.; Penzias, Alan S.; Connoly-Diamond, Meredith; Jones, Ervin E.; Diamond, Michael P.

doi:10.1016/s0015-0282(16)57479-2

Cited by 25 publications

(1 citation statement)

References 19 publications

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“…Increased glucose involved in heavier DMPA users or long treatment duration users (29). Other studies also observed an increase in insulin area under the curve with etonogestrel implants after oral glucose tolerance test and in Norplant users, an elevation of glucose concentrations which is intensified with greater implant use period and returned to baseline after removal (30,31). This presumption of insulin resistance was supported by a finding of increased free fatty acids after glucose challenge among DMPA users (32).…”

Section: Discussionmentioning

confidence: 87%

Progestogen-Only Contraceptives and the Risk of Acute Myocardial Infarction: A Meta-Analysis

Chakhtoura

Canonico

Gompel

et al. 2011

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionmentioning

confidence: 87%

Progestogen-Only Contraceptives and the Risk of Acute Myocardial Infarction: A Meta-Analysis

Chakhtoura

Canonico

Gompel

et al. 2011

The Journal of Clinical Endocrinology &Amp; Metabolism

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Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?

Corbould

2008

Diabetes Metabolism Res

120

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Hyperinsulinemia as a consequence of insulin resistance causes hyperandrogenemia in women. The objective was to review evidence for the converse situation, i.e. whether androgens adversely influence insulin action. Androgen excess could potentially contribute to the pathogenesis of insulin resistance in women with polycystic ovary syndrome (PCOS), metabolic syndrome/type 2 diabetes, and in obese peripubertal girls. An Entrez-PubMed search was conducted to identify studies addressing the relationship of androgens with metabolic syndrome/type 2 diabetes in women. Studies reporting outcomes of androgen administration, interventions to reduce androgen effects in hyperandrogenemic women, and basic studies investigating androgen effects on insulin target tissues were reviewed. Multiple studies showed associations between serum testosterone and insulin resistance or metabolic syndrome/type 2 diabetes risk in women, but their cross-sectional nature did not allow conclusions about causality. Androgen administration to healthy women was associated with development of insulin resistance. Intervention studies in women with hyperandrogenism were limited by small subject numbers and use of indirect methods for assessing insulin sensitivity. However, in three of the seven studies using euglycemic hyperinsulinemic clamps, reduction of androgen levels or blockade of androgen action improved insulin sensitivity. Testosterone administration to female rats caused skeletal muscle insulin resistance. Testosterone induced insulin resistance in adipocytes of women in vitro. In conclusion, the metabolic consequences of androgen excess in women have been under-researched. Studies of long-term interventions that lower androgen levels or block androgen effects in young women with hyperandrogenism are needed to determine whether these might protect against metabolic syndrome/type 2 diabetes in later life.

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The role of androgens in metabolism, obesity, and diabetes in males and females

Navarro

Allard

et al. 2015

Obesity

213

163

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Objectives In men, androgen deprivation contributes to the development of metabolic syndrome and type 2 diabetes (T2D). In women, androgen excess predisposes to insulin resistance and T2D. There is a bidirectional modulation of glucose homeostasis by androgen in males and females that we analyze in this review. Methods We review the literature in both rodents and humans on the role of androgens and the androgen receptor (AR) in the control of glucose and energy metabolism in health, obesity and T2D. Results Sex-specific activation of AR in the hypothalamus, skeletal muscle, liver, adipose tissue and pancreatic islet β cells accounts for maintenance or disruption in energy metabolism and glucose homeostasis. Conclusion We argue that AR is a target to prevent androgen-related metabolic disorders.

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The effect of Norplant on glucose metabolism under hyperglycemic hyperinsulinemic conditions

Cited by 25 publications

References 19 publications

Progestogen-Only Contraceptives and the Risk of Acute Myocardial Infarction: A Meta-Analysis

Progestogen-Only Contraceptives and the Risk of Acute Myocardial Infarction: A Meta-Analysis

Effects of androgens on insulin action in women: is androgen excess a component of female metabolic syndrome?

The role of androgens in metabolism, obesity, and diabetes in males and females

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