“…In these cases, the activities of adenylate cyclase and protein kinase fluctuate during the cell cycle (Jungmann & Russell, 1977;Bachrach et al, 1978). It has been demonstrated that polyamines affect the activity of adenylate cyclase (Shah et al, 1975;Atmar et al, 1976;Caldarera et al, 1976;Sheth et al, 1976;Wright et al, 1976) and of cyclic AMP-dependent protein kinase (Takai et al, 1976;Murray et al, 1976;Maenpaa, 1977;Hochmanetal., 1978), apparently by interacting with its catalytic subunit . This may be another self-regulatory mechanism which controls the synthesis of polyamines.…”